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机器人: 已有较多条目链入本条目

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[[File:E. coli Bacteria (7316101966).jpg|thumb|right|[[大腸桿菌]]是第一種發現帶有''mcr-1''基因的菌種]]

'''MCR-1'''是第一種通過''mcr-1''[[基因]]對[[粘桿菌素]]（一種[[多粘菌素]]和最後一線用藥）產生-{zh-hant:質體; zh-hans:质粒;}-介导（plasmid-mediated）[[抗生素抗藥性]]的遺傳機制<ref name = "Lancet">{{cite journal | last1 = Liu | first1 = YY | last2 = Wang | first2 = Y | last3 = Walsh | first3 = TR | last4 = Yi | first4 = LX | last5 = Zhang | first5 = R | last6 = Spencer | first6 = J | last7 = Doi | first7 = Y | last8 = Tian | first8 = G | last9 = Dong | first9 = B | last10 = Huang | first10 = X | last11 = Yu | first11 = LF | last12 = Gu | first12 = D | last13 = Ren | first13 = H | last14 = Chen | first14 = X | last15 = Lv | first15 = L | last16 = He | first16 = D | last17 = Zhou | first17 = H | last18 = Liang | first18 = Z | last19 = Liu | first19 = JH | last20 = Shen | first20 = J | title = Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. | journal = ''[[柳葉刀 (雜誌)|The Lancet. Infectious diseases]]'' | doi = 10.1016/S1473-3099(15)00424-7 | pmid = 26603172 | date = 2015-11-18 | accessdate = 2016-05-27 | url = http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(15)00424-7/abstract | language = en | archive-date = 2018-09-08 | archive-url = https://web.archive.org/web/20180908150855/https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(15)00424-7/abstract | dead-url = no }}</ref><ref>{{cite journal | last1 = Reardon | first1 = Sara | title = Spread of antibiotic-resistance gene does not spell bacterial apocalypse — yet | journal = ''[[自然 (期刊)|Nature]]'' | doi = 10.1038/nature.2015.19037 | url = http://www.nature.com/news/spread-of-antibiotic-resistance-gene-does-not-spell-bacterial-apocalypse-yet-1.19037 | date = 2015-12-21 | accessdate = 2016-05-27 | language = en | archive-date = 2020-08-03 | archive-url = https://web.archive.org/web/20200803073639/https://www.nature.com/news/spread-of-antibiotic-resistance-gene-does-not-spell-bacterial-apocalypse-yet-1.19037 | dead-url = no }}</ref>。此機制最早於2015年11月時在中國豬隻中帶有的[[大腸桿菌]]SHP45型發現，之後並由馬來西亞、英國<ref>{{cite web | title = More MCR-1 findings lead to calls to ban ag use of colistin | publisher = [[明尼蘇達大學]]傳染病研究及政策中心（Center for Infectious Disease Research and Policy） | url = http://www.cidrap.umn.edu/news-perspective/2015/12/more-mcr-1-findings-lead-calls-ban-ag-use-colistin | date = 2015-12-18 | accessdate = 2015-12-22 | language = en | archive-date = 2020-02-16 | archive-url = https://web.archive.org/web/20200216112138/http://www.cidrap.umn.edu/news-perspective/2015/12/more-mcr-1-findings-lead-calls-ban-ag-use-colistin | dead-url = no }}</ref>、中國<ref name = "Lancet" />、歐洲<ref>{{cite web | title = Apocalypse Pig Redux: Last-Resort Resistance in Europe | last1 = McKenna | first1 = Maryn | publisher = [[國家地理學會]] | url = http://phenomena.nationalgeographic.com/2015/12/03/colistin-r-2/ | date = 2015-12-03 | accessdate = 2016-05-27 | language = en | archive-date = 2016-05-28 | archive-url = https://web.archive.org/web/20160528163333/http://phenomena.nationalgeographic.com/2015/12/03/colistin-r-2/ | dead-url = no }}</ref>和美國<ref>{{Cite web | title = First discovery in United States of colistin resistance in a human E. coli infection | author = The U.S. Military HIV Research Program (MHRP) | url = https://www.sciencedaily.com/releases/2016/05/160526152033.htm | website = www.sciencedaily.com | date = 2016-05-26 | accessdate = 2016-05-27 | language = en | archive-date = 2016-05-27 | archive-url = https://web.archive.org/web/20160527122712/https://www.sciencedaily.com/releases/2016/05/160526152033.htm | dead-url = no }}</ref>等不同研究單位在人類檢體中發現。本機制也是首個可在細菌間以[[基因水平轉移]]傳播的抗多粘菌素機制。

== 參見 ==
* [[新德里金屬-β-內醯胺酶1]]

== 參考資料 ==
{{reflist}}

[[Category:基因]]
[[Category:抗生素抗藥性]]
[[Category:大腸桿菌]]

{{genetics-stub}}

MCR-1 - 版本历史

imported>Jimmy-bot：​机器人: 已有较多条目链入本条目

imported>Jimmy-bot：机器人: 已有较多条目链入本条目