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<p></p> <p><b>新页面</b></p><div>{{PBB|geneid=5648}}<br /> &#039;&#039;&#039;甘露糖结合凝集素丝氨酸蛋白酶1&#039;&#039;&#039; （Mannan-binding lectin serine protease 1，也被称为 &#039;&#039;&#039;甘露糖相关丝氨酸蛋白酶1&#039;&#039;&#039;，mannose-associated serine protease 1，缩写&#039;&#039;&#039;MASP-1&#039;&#039;&#039;）化学式为：C&lt;sub&gt;4016&lt;/sub&gt;H&lt;sub&gt;6153&lt;/sub&gt;O&lt;sub&gt;1468&lt;/sub&gt;N&lt;sub&gt;957&lt;/sub&gt;S&lt;sub&gt;43&lt;/sub&gt;&lt;ref&gt;{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P48740@20-699@ |website=web.expasy.org |access-date=2026-02-10}}&lt;/ref&gt;是由人类[[基因]] &#039;&#039;MASP1&#039;&#039; 编码的一种[[酶]]。&lt;ref name=&quot;pmid8240317&quot;&gt;{{Cite journal|title=A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum|date=Oct 1993|journal=Biochemical and Biophysical Research Communications|issue=2|doi=10.1006/bbrc.1993.2349|volume=196|pages=1003–9|pmid=8240317}}&lt;/ref&gt;&lt;ref name=&quot;pmid8018603&quot;&gt;{{Cite journal|title=Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein|date=Apr 1994|journal=International Immunology|issue=4|doi=10.1093/intimm/6.4.665|volume=6|pages=665–9|pmid=8018603}}&lt;/ref&gt;&lt;ref name=&quot;entrez&quot;&gt;{{Cite web|url=http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&amp;Cmd=ShowDetailView&amp;TermToSearch=5648|title=Entrez Gene: mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)|accessdate=}}&lt;/ref&gt;<br /> <br /> MASP-1参与[[补体系统]]的凝集素途径，负责的切割[[补体成分4|C4]]和[[补体成分2|C2]]形成C4b2a，作为[[C3-转化酶]]参与下一步的反应。&lt;ref name=&quot;pmid10946292&quot;&gt;{{Cite journal|title=Proteolytic activities of two types of mannose-binding lectin-associated serine protease|url=http://www.jimmunol.org/cgi/content/abstract/165/5/2637|date=Sep 2000|journal=Journal of Immunology|issue=5|doi=10.4049/jimmunol.165.5.2637|volume=165|pages=2637–42|pmid=10946292|access-date=2016-11-24|archive-date=2009-01-09|archive-url=https://web.archive.org/web/20090109001715/http://www.jimmunol.org/cgi/content/abstract/165/5/2637|dead-url=no}}&lt;/ref&gt;<br /> <br /> == 另见 ==<br /> * [[甘露聚糖结合凝集素]]<br /> <br /> == 参考文献 ==<br /> {{Reflist}}<br /> <br /> == 外部链接 ==<br /> * {{MeshName|MASP+Proteases}}<br /> {{NLM content}}<br /> {{丝氨酸内肽酶类}}<br /> {{补体系统}}<br /> [[Category:补体系统]]<br /> [[Category:EC 3.4.21]]<br /> [[Category:位於3號人類染色體的基因]]</div>

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