imported>Cewbot：清理跨語言連結重编程成為內部連結:編輯摘要的紅色連結經繁簡轉換後存在，非bot錯誤編輯 (本次機械人作業已完成27%)

2026-03-08T11:53:34Z

清理跨語言連結重编程成為內部連結:編輯摘要的紅色連結經繁簡轉換後存在，非bot錯誤編輯 (本次機械人作業已完成27%)

新页面

{{Infobox_gene}}
'''Kruppel样因子4'''（{{langx|en|Kruppel-like factor 4}}，缩写'''KLF4'''）或'''肠富集Krüppel样因子'''（{{langx|en|gut-enriched Krüppel-like factor}}，缩写'''GKLF'''）化学式为：C2399H3707O719N703S24<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?O43474@1-513@ |website=web.expasy.org |access-date=2026-01-24}}</ref>是[[锌指]][[转录因子]]{{le|KLF家族|KLF family}}的一个成员，后者属于一个较大的{{tsl|en|Sp1 transcription factor|SP1转录因子|SP1}}样转录因子家族<ref>{{cite journal | vauthors = Black AR, Black JD, Azizkhan-Clifford J | title = Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer | url = https://archive.org/details/sim_journal-of-cellular-physiology_2001-08_188_2/page/143 | journal = Journal of Cellular Physiology | volume = 188 | issue = 2 | pages = 143–60 | date = August 2001 | pmid = 11424081 | doi = 10.1002/jcp.1111}}</ref><ref name="pmid11137451">{{cite journal | vauthors = Dang DT, Pevsner J, Yang VW | title = The biology of the mammalian Krüppel-like family of transcription factors | journal = The International Journal of Biochemistry & Cell Biology | volume = 32 | issue = 11–12 | pages = 1103–21 | date = November 2000 | pmid = 11137451 | doi=10.1016/s1357-2725(00)00059-5 | pmc=2754176}}</ref><ref>{{cite journal | vauthors = Kaczynski J, Cook T, Urrutia R | title = Sp1- and Krüppel-like transcription factors | journal = Genome Biology | volume = 4 | issue = 2 | pages = 206 | year = 2003 | pmid = 12620113 | pmc=151296 | doi=10.1186/gb-2003-4-2-206 }}</ref>。KLF4参与[[細胞增殖]]、[[细胞分化]]、[[细胞凋亡]]和[[体细胞]][[重编程]]的调节。有证据表明KLF4在包括[[大腸癌]]在内的一些癌症中是[[肿瘤抑制基因]]<ref>{{cite journal | vauthors = El-Karim EA, Hagos EG, Ghaleb AM, Yu B, Yang VW | title = Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts | journal = Molecular Cancer | volume = 12 | pages = 89 | date = August 2013 | pmid = 23919723| doi = 10.1186/1476-4598-12-89 | pmc=3750599}}</ref>。与{{tsl|en|KLF2|KLF2}}类似，它在[[C端]]有三个C2H2型[[锌指]]<ref name="pmid11137451" />。它有两个[[核定位序列]]指引它定位于细胞核内<ref>{{cite journal | vauthors = Shields JM, Yang VW | title = Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins | url = https://archive.org/details/sim_journal-of-biological-chemistry_1997-07-18_272_29/page/18504 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 29 | pages = 18504–7 | date = July 1997 | pmid = 9218496 | doi=10.1074/jbc.272.29.18504 | pmc=2268085}}</ref>。在[[胚胎幹細胞]](ESCs)和[[間充質幹細胞]](MSCs)中KLF4是显示多能化的很好标记。

==参考==
{{reflist}}
== 外部链接 ==
* {{MeshName|KLF4+protein,+human}}
* [http://www.nextbio.com/b/home/home.nb?q=KLF4&id=34891&type=feature&name=KLF4&synonym= KLF4 microarray expression results and literature]{{Dead link}}

{{Transcription factors|g2}}

{{NLM content}}

[[Category:转录因子]]

KLF4 - 版本历史

imported>Cewbot：​清理跨語言連結重编程成為內部連結:編輯摘要的紅色連結經繁簡轉換後存在，非bot錯誤編輯 (本次機械人作業已完成27%)

imported>Cewbot：清理跨語言連結重编程成為內部連結:編輯摘要的紅色連結經繁簡轉換後存在，非bot錯誤編輯 (本次機械人作業已完成27%)