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JWH-424 - 版本历史
2026-07-18T21:55:03Z
本wiki上该页面的版本历史
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https://arolstar52-zhtest.hf.space/index.php?title=JWH-424&diff=4369619&oldid=prev
imported>Jimmy-bot：机器人: 尚未清空的已重定向分类） （Cat:狡詐家藥物→Cat:策划药
2025-08-15T10:30:40Z
<p>机器人: 尚未清空的已重定向分类） （<a href="/index.php?title=Cat:%E7%8B%A1%E8%A9%90%E5%AE%B6%E8%97%A5%E7%89%A9&action=edit&redlink=1" class="new" title="Cat:狡詐家藥物（页面不存在）">Cat:狡詐家藥物</a>→<a href="/index.php?title=Cat:%E7%AD%96%E5%88%92%E8%8D%AF&action=edit&redlink=1" class="new" title="Cat:策划药（页面不存在）">Cat:策划药</a></p>
<p><b>新页面</b></p><div>{{Drugbox<br />
| Watchedfields = changed<br />
| verifiedrevid = 433533861<br />
| IUPAC_name = 1-Pentyl-3-(8-bromo-1-naphthoyl)indole<br />
| image = JWH-424.svg<br />
| width = 150<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = Schedule II<br />
| legal_DE = NpSG<br />
| legal_UK = Class B<br />
| legal_US = Schedule I<br />
| legal_status = <br />
| routes_of_administration = <br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
<br />
<!--Identifiers--><br />
| CAS_number = 1366068-04-3<br />
| CAS_number_Ref = {{cascite|correct|CAS}}<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = O4Q3AIP6BJ<br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| PubChem = 57458937<br />
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}<br />
| DrugBank = <br />
| ChemSpiderID = 28645324<br />
<br />
<!--Chemical data--><br />
| C=24 | H=22 | Br=1 | N=1 | O=1 <br />
| smiles = c4cccc1c4n(CCCCC)cc1C(=O)c(c2c3Br)cccc2ccc3<br />
| StdInChI = 1S/C24H22BrNO/c1-2-3-6-15-26-16-20(18-11-4-5-14-22(18)26)24(27)19-12-7-9-17-10-8-13-21(25)23(17)19/h4-5,7-14,16H,2-3,6,15H2,1H3<br />
| StdInChIKey = QXZYVJRMQVOOEQ-UHFFFAOYSA-N<br />
<br />
}}<br />
<br />
'''JWH-424'''是[[萘甲酰基吲哚]]家族的一种药物，可作为[[大麻素受体1|CB<sub>1</sub>]]和[[大麻素受体2|CB<sub>2</sub>受体]]的[[大麻素]][[激动剂]]，但对CB<sub>2</sub>具有中等选择性，CB<sub>2</sub>的[[解离常数|K<sub>i</sub>值]]为5.44 nM，而CB<sub>1</sub>的K<sub>i</sub>值为20.9 nM。较重的8-碘类似物对CB<sub>2</sub>的选择性更高，其2-甲基衍生物对CB<sub>2</sub>的选择性是其40倍。然而，该系列中的1-丙基同系物对两种受体的亲和力均低得多，反映出对8-取代萘甲酰基吲哚总体上亲和力普遍降低。<ref name="pmid22341572">{{cite journal | vauthors = Wiley JL, Smith VJ, Chen J, Martin BR, Huffman JW | title = Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituents | journal = Bioorganic & Medicinal Chemistry | volume = 20 | issue = 6 | pages = 2067–81 | date = March 2012 | pmid = 22341572 | pmc = 3298571 | doi = 10.1016/j.bmc.2012.01.038 }}</ref><br />
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在美国，所有3-(1-萘甲酰基)吲哚类CB<sub>1</sub>受体激动剂（例如JWH-424）均属于{{le|附表I管制物质|List of Schedule I controlled substances (U.S.)}}。<ref>{{UnitedStatesCode2|21|812|Schedules of controlled substances}}</ref><br />
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==参见==<br />
* [[JWH-018]]<br />
* [[JWH-398]]<br />
<br />
==参考资料==<br />
{{reflist}}<br />
<br />
{{大麻素}}<br />
<br />
[[Category:萘甲酰基吲哚]]<br />
[[Category:JWH大麻素]]<br />
[[Category:溴萘]]<br />
[[Category:策划药]]<br />
[[Category:CB1受体激动剂]]</div>
imported>Jimmy-bot