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JWH-147 - 版本历史
2026-07-18T23:27:52Z
本wiki上该页面的版本历史
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2025年2月8日 (六) 09:05 imported>Leiem
2025-02-08T09:05:07Z
<p></p>
<p><b>新页面</b></p><div>{{Drugbox<br />
| Verifiedfields = changed<br />
| Watchedfields = changed<br />
| verifiedrevid = 443831499<br />
| IUPAC_name = (1-Hexyl-5-phenyl-1''H''-pyrrol-3-yl)-1-naphthalenyl-methanone<br />
| image = JWH-147.svg<br />
| image_class = skin-invert-image<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --><br />
| legal_UK = class B<!-- GSL / P / POM / CD / Class A, B, C --><br />
| legal_US = Schedule I<br />
| legal_status = Illegal in Sweden<br />
| routes_of_administration = <br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
<br />
<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|CAS}}<br />
| CAS_number = 914458-20-1<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = MQ6N4B8QWE<br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| PubChem = <br />
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}<br />
| DrugBank = <br />
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}<br />
| ChemSpiderID = 23277882<br />
<br />
<br />
<!--Chemical data--><br />
| C=27 | H=27 | N=1 | O=1 <br />
| smiles = c4ccccc4-c2cc(cn2CCCCCC)C(=O)c1cccc3c1cccc3<br />
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChI = 1S/C27H27NO/c1-2-3-4-10-18-28-20-23(19-26(28)22-13-6-5-7-14-22)27(29)25-17-11-15-21-12-8-9-16-24(21)25/h5-9,11-17,19-20H,2-4,10,18H2,1H3<br />
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChIKey = FRMYAMAGHYHNKF-UHFFFAOYSA-N<br />
}}<br />
'''{{PAGENAMEBASE}}'''，化学名'''''N''-正己基-5-苯基-3-(1-萘甲酰基)吡咯'''，分子式[[C27H27NO|{{chem2|C27H27NO}}]]，属于[[萘甲酰基]][[吡咯]]类[[JWH大麻素列表|JWH系列大麻素]]，是[[大麻素受体]]CB<sub>1</sub>和CB<sub>2</sub>的[[激动剂]]<ref name="pmid16889960">{{cite journal | vauthors = Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR | title = 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB<sub>1</sub> and CB<sub>2</sub> receptors | journal = Bioorganic & Medicinal Chemistry Letters | volume = 16 | issue = 20 | pages = 5432–5 | date = October 2006 | pmid = 16889960 | doi = 10.1016/j.bmcl.2006.07.051 }}</ref>。它可通过LC-MS法检测，其前体离子的m/z为382，产物离子的m/z为127。<ref>Arianna Giorgetti; et al. Development and validation of a rapid LC-MS/MS method for the detection of 182 novel psychoactive substances in whole blood. Drug Testing and Analysis (2022), 14 (2), 202-223. {{doi|10.1002/dta.3170}}.</ref><br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:JWH大麻素]]<br />
[[Category:CB1受体激动剂]]<br />
[[Category:CB2受体激动剂]]<br />
[[Category:正己基化合物]]<br />
[[Category:萘甲酰基吡咯]]<br />
[[Category:苯基化合物]]</div>
imported>Leiem