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JWH-073 - 版本历史
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<p><b>新页面</b></p><div>{{Expand English|date=2024-01-29}}<br />
{{Drugbox<br />
| Verifiedfields = changed<br />
| Watchedfields = changed<br />
| verifiedrevid = 451057329<br />
| IUPAC_name = Naphthalen-1-yl-(1-butylindol-3-yl)methanone<br />
| image = JWH073.svg<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_BR = F2<br />
| legal_BR_comment = <ref>{{Cite web |author=Anvisa |author-link=Brazilian Health Regulatory Agency |date=2023-07-24 |title=RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial |trans-title=Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control|url=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451 |url-status=live |archive-url=https://web.archive.org/web/20230827163149/https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451 |archive-date=2023-08-27 |access-date=2023-08-27 |publisher=[[Diário Oficial da União]] |language=pt-BR |publication-date=2023-07-25}}</ref><br />
| legal_CA = Schedule II<br />
| legal_UK = Class B<br />
| legal_US = Schedule I<br />
| legal_DE = Anlage II<br />
| legal_status = Illegal in Latvia<ref>{{cite web | title = Grozījumi Ministru kabineta 2005.gada 8.novembra noteikumos Nr.847 "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem" | language = Latvian | work = Legal Acts of the Republic of Latvia | url = http://www.likumi.lv/doc.php?id=201101&from=off | access-date = 2024-01-29 | archive-date = 2010-09-14 | archive-url = https://web.archive.org/web/20100914075503/http://www.likumi.lv/doc.php?id=201101&from=off | dead-url = no }}</ref> & Poland<br />
| routes_of_administration =<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion =<br />
<br />
<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|??}}<br />
| CAS_number = 208987-48-8<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = BBX3BP2772<br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| PubChem = 10471670<br />
| KEGG = C22764<br />
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}<br />
| DrugBank = <br />
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}<br />
| ChemSpiderID = 8647081<br />
<!--Chemical data--><br />
| C=23 | H=21 | N=1 | O=1 <br />
| smiles = CCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43<br />
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChI = 1S/C23H21NO/c1-2-3-15-24-16-21(19-12-6-7-14-22(19)24)23(25)20-13-8-10-17-9-4-5-11-18(17)20/h4-14,16H,2-3,15H2,1H3<br />
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChIKey = VCHHHSMPMLNVGS-UHFFFAOYSA-N<br />
<br />
}}<br />
'''{{PAGENAMEBASE}}'''，化学名'''''N''-正丁基-3-(1-萘甲酰基)吲哚'''，分子式[[C23H21NO|C<sub>23</sub>H<sub>21</sub>NO]]，属于[[萘甲酰基吲哚]]类[[JWH大麻素列表|JWH系列大麻素]]，是[[大麻素受体]]CB<sub>1</sub>和CB<sub>2</sub>的全[[激动剂]]<ref name="pmid22266354">{{cite journal |author=Lisa K. Brents, Anna Gallus-Zawada, Anna Radominska-Pandya, Tamara Vasiljevik, Thomas E Prisinzano, William E Fantegrossi, Jeffery H Moran, Paul L Prather |title=Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity |journal=Biochemical Pharmacology |volume=83 |issue=7 |pages=952-961 |year=2012 |pmid=22266354 |doi=10.1016/j.bcp.2012.01.004 |url=https://pubmed.ncbi.nlm.nih.gov/22266354/ |quote=JWH-073 displays equivalent efficacy to that of the CB1R full agonist CP-55,940 |hdl=1808/22684 |hdl-access=free |access-date=2024-01-29 |archive-date=2023-10-31 |archive-url=https://web.archive.org/web/20231031161925/https://pubmed.ncbi.nlm.nih.gov/22266354/ |dead-url=no }}</ref>，由[[约翰·威廉·霍夫曼]]小组合成<ref name="pmid10940540">{{cite journal |vauthors=Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR | title = Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB<sub>1</sub> and CB<sub>2</sub>)receptor binding |url=https://archive.org/details/sim_drug-and-alcohol-dependence_2000-08-01_60_2/page/132 | journal = Drug Alcohol Depend | volume = 60 | issue = 2 | pages = 133–40 |date=August 2000 | pmid = 10940540 | doi =10.1016/S0376-8716(99)00152-0 }}</ref>。<br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
==外部链接==<br />
<br />
[[Category:策划药]]<br />
[[Category:JWH大麻素]]<br />
[[Category:CB1受体激动剂]]<br />
[[Category:CB2受体激动剂]]<br />
[[Category:正丁基化合物]]<br />
[[Category:萘甲酰基吲哚]]</div>
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