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{{Infobox_gene}}

'''HTN3'''，是一能夠指導組氨素3合成的[[基因]]片段<ref name="entrez">{{cite web| title = Entrez Gene: HTN3 histatin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3347| accessdate = | archive-date = 2019-10-17| archive-url = https://web.archive.org/web/20191017064947/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3347| dead-url = no}}</ref><ref name="pmid2719677">{{cite journal | author = Sabatini LM, Azen EA | title = Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2) | journal = Biochem. Biophys. Res. Commun. | volume = 160 | issue = 2 | pages = 495–502 | date = April 1989 | pmid = 2719677 | doi = 10.1016/0006-291X(89)92460-1 | url = http://linkinghub.elsevier.com/retrieve/pii/0006-291X(89)92460-1 | access-date = 2015-03-14 | archive-date = 2019-02-16 | archive-url = https://web.archive.org/web/20190216132243/https://linkinghub.elsevier.com/retrieve/pii/0006-291X(89)92460-1 | dead-url = no }}</ref>，组氨素化学式为：C279H418O69N84S3<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P15516@noft@ |website=web.expasy.org |access-date=2025-07-11}}</ref>。

== 功能 ==
HTN3基因表達的初級產物爲組氨素3。[[組氨素]]是一類存在於唾液中的富含[[組氨酸]]的[[蛋白質]]，控制其合成的基因位點除了HTN3之外，還有H1N1。組氨素3在合成完畢後，還可以通過蛋白水解轉化成其它的組氨素（比如組氨素4-6）。能控制組氨素3合成的等位基因爲HIS2<ref name="pmid18650243">{{cite journal | author = Oudhoff MJ, Bolscher JG, Nazmi K, Kalay H, van 't Hof W, Amerongen AV, Veerman EC | title = Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay | journal = FASEB J. | volume = 22 | issue = 11 | pages = 3805–12 |date=November 2008 | pmid = 18650243 | doi = 10.1096/fj.08-112003 | url =https://archive.org/details/sim_faseb-journal_2008-11_22_11/page/3805}}</ref>。

{| class="wikitable" border="1" style="text-align:center"
|-
! 等位基因
! 基因
! 蛋白質
|-
| HIS1
| [[HTN1]]
| 組氨素 1
|-
| HIS2
| HTN3
| 組氨素 3 → 組氨素 4-6
|}

==參考==
{{reflist}}

==拓展閱讀==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Troxler RF, Offner GD, Xu T, ''et al.'' |title=Structural relationship between human salivary histatins. | url=https://archive.org/details/sim_journal-of-dental-research_1990-01_69_1/page/2 |journal=J. Dent. Res. |volume=69 |issue= 1 |pages= 2–6 |year= 1990 |pmid= 2303595 |doi= 10.1177/00220345900690010101}}
*{{cite journal | author=vanderSpek JC, Offner GD, Troxler RF, Oppenheim FG |title=Molecular cloning of human submandibular histatins. | url=https://archive.org/details/sim_archives-of-oral-biology_1990_35_2/page/137 |journal=Arch. Oral Biol. |volume=35 |issue= 2 |pages= 137–43 |year= 1990 |pmid= 2344289 |doi=10.1016/0003-9969(90)90175-A }}
*{{cite journal | author=Sugiyama K, Ogino T, Ogata K |title=Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva. | url=https://archive.org/details/sim_archives-of-oral-biology_1990_35_6/page/415 |journal=Arch. Oral Biol. |volume=35 |issue= 6 |pages= 415–9 |year= 1990 |pmid= 2372245 |doi=10.1016/0003-9969(90)90202-L }}
*{{cite journal | author=Sabatini LM, Azen EA |title=Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2). |journal=Biochem. Biophys. Res. Commun. |volume=160 |issue= 2 |pages= 495–502 |year= 1989 |pmid= 2719677 |doi=10.1016/0006-291X(89)92460-1 }}
*{{cite journal | author=vanderSpek JC, Wyandt HE, Skare JC, ''et al.'' |title=Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs. | url=https://archive.org/details/sim_american-journal-of-human-genetics_1989-09_45_3/page/381 |journal=Am. J. Hum. Genet. |volume=45 |issue= 3 |pages= 381–7 |year= 1989 |pmid= 2773933 |doi= | pmc=1683406 }}
*{{cite journal | author=Oppenheim FG, Xu T, McMillian FM, ''et al.'' |title=Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. | url=https://archive.org/details/sim_journal-of-biological-chemistry_1988-06-05_263_16/page/7472 |journal=J. Biol. Chem. |volume=263 |issue= 16 |pages= 7472–7 |year= 1988 |pmid= 3286634 |doi= }}
*{{cite journal | author=Dickinson DP, Ridall AL, Levine MJ |title=Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence. |journal=Biochem. Biophys. Res. Commun. |volume=149 |issue= 2 |pages= 784–90 |year= 1988 |pmid= 3426601 |doi=10.1016/0006-291X(87)90436-0 }}
*{{cite journal | author=Sabatini LM, Azen EA |title=Two coding change mutations in the HIS2(2) allele characterize the salivary histatin 3-2 protein variant. |journal=Hum. Mutat. |volume=4 |issue= 1 |pages= 12–9 |year= 1994 |pmid= 7951254 |doi= 10.1002/humu.1380040103 }}
*{{cite journal | author=Sabatini LM, Ota T, Azen EA |title=Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. | url=https://archive.org/details/sim_molecular-biology-and-evolution_1993-05_10_3/page/497 |journal=Mol. Biol. Evol. |volume=10 |issue= 3 |pages= 497–511 |year= 1993 |pmid= 8336540 |doi= }}
*{{cite journal | author=Tsai H, Raj PA, Bobek LA |title=Candidacidal activity of recombinant human salivary histatin-5 and variants. |journal=Infect. Immun. |volume=64 |issue= 12 |pages= 5000–7 |year= 1997 |pmid= 8945538 |doi= | pmc=174480 }}
*{{cite journal | author=Iontcheva I, Oppenheim FG, Offner GD, Troxler RF |title=Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system. |journal=J. Dent. Res. |volume=79 |issue= 2 |pages= 732–9 |year= 2000 |pmid= 10728974 |doi=10.1177/00220345000790020601 }}
*{{cite journal | author=Naurato N, Wong P, Lu Y, ''et al.'' |title=Interaction of tannin with human salivary histatins. |journal=J. Agric. Food Chem. |volume=47 |issue= 6 |pages= 2229–34 |year= 2000 |pmid= 10794615 |doi=10.1021/jf981044i }}
*{{cite journal | author=Gusman H, Travis J, Helmerhorst EJ, ''et al.'' |title=Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease. | url=https://archive.org/details/sim_infection-and-immunity_2001-03_69_3/page/1402 |journal=Infect. Immun. |volume=69 |issue= 3 |pages= 1402–8 |year= 2001 |pmid= 11179305 |doi= 10.1128/IAI.69.3.1402-1408.2001 | pmc=98034 }}
*{{cite journal | author=Grogan J, McKnight CJ, Troxler RF, Oppenheim FG |title=Zinc and copper bind to unique sites of histatin 5. |journal=FEBS Lett. |volume=491 |issue= 1–2 |pages= 76–80 |year= 2001 |pmid= 11226423 |doi=10.1016/S0014-5793(01)02157-3 }}
*{{cite journal | author=Gyurko C, Lendenmann U, Helmerhorst EJ, ''et al.'' |title=Killing of Candida albicans by histatin 5: cellular uptake and energy requirement |journal=Antonie Van Leeuwenhoek |volume=79 |issue= 3–4 |pages= 297–309 |year= 2002 |pmid= 11816973 |doi=10.1023/A:1012070600340 }}
*{{cite journal | author=Baev D, Li XS, Dong J, ''et al.'' |title=Human salivary histatin 5 causes disordered volume regulation and cell cycle arrest in Candida albicans | url=https://archive.org/details/sim_infection-and-immunity_2002-09_70_9/page/4777 |journal=Infect. Immun. |volume=70 |issue= 9 |pages= 4777–84 |year= 2002 |pmid= 12183519 |doi=10.1128/IAI.70.9.4777-4784.2002 | pmc=128240 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Li XS, Reddy MS, Baev D, Edgerton M |title=Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5 | url=https://archive.org/details/sim_journal-of-biological-chemistry_2003-08-01_278_31/page/28552 |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28553–61 |year= 2003 |pmid= 12761219 |doi= 10.1074/jbc.M300680200 }}
*{{cite journal | author=Ahmad M, Piludu M, Oppenheim FG, ''et al.'' |title=Immunocytochemical localization of histatins in human salivary glands |journal=J. Histochem. Cytochem. |volume=52 |issue= 3 |pages= 361–70 |year= 2004 |pmid= 14966203 |doi= 10.1177/002215540405200307}}
*{{cite journal | author=Castagnola M, Inzitari R, Rossetti DV, ''et al.'' |title=A cascade of 24 histatins (histatin 3 fragments) in human saliva. Suggestions for a pre-secretory sequential cleavage pathway | url=https://archive.org/details/sim_journal-of-biological-chemistry_2004-10-01_279_40/page/41436 |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41436–43 |year= 2004 |pmid= 15272024 |doi= 10.1074/jbc.M404322200 }}
}}
{{refend}}


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{{Pore-forming toxins}}

[[Category:抗微生物肽]]

HTN3 - 版本历史

imported>InternetArchiveBot：​Fixing 1 dead IA link per WP:DEADIABOOKLINKS (20260529simdark)) #IABot (v2.0.9.5) (GreenC bot

imported>InternetArchiveBot：Fixing 1 dead IA link per WP:DEADIABOOKLINKS (20260529simdark)) #IABot (v2.0.9.5) (GreenC bot