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HTN1 - 版本历史
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'''組氨素1'''（{{langx|en|'''Histatin-1'''}}），是一類由HTN1基因編碼的蛋白質<ref name="entrez">{{cite web| title = Entrez Gene: HTN1 histatin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3346| accessdate = | archive-date = 2019-10-17| archive-url = https://web.archive.org/web/20191017064817/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3346| dead-url = no}}</ref>，其编码的[[組氨素]]1还能降解为組氨素2。組氨素1化学式为：C<sub>158</sub>H<sub>211</sub>O<sub>44</sub>N<sub>45</sub><ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P15515@31-57@ |website=web.expasy.org |access-date=2025-07-11}}</ref><br />
{| class="wikitable" border="1" style="text-align:center"<br />
|-<br />
! 等位基因<br />
! 基因<br />
! 蛋白質<br />
|-<br />
| HIS1<br />
| HTN1<br />
| 組氨素 1 → 組氨素 2<br />
|-<br />
| HIS2<br />
| [[HTN3]]<br />
| 組氨素 3 → 組氨素 4-6<br />
|}<br />
<br />
==参考文献==<br />
{{reflist}}<br />
==延伸阅读==<br />
{{refbegin | 2}}<br />
{{PBB_Further_reading <br />
| citations = <br />
*{{cite journal | author=Sugiyama K, Ogino T, Ogata K |title=Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva. | url=https://archive.org/details/sim_archives-of-oral-biology_1990_35_6/page/415 |journal=Arch. Oral Biol. |volume=35 |issue= 6 |pages= 415–9 |year= 1990 |pmid= 2372245 |doi=10.1016/0003-9969(90)90202-L }}<br />
*{{cite journal | author=Sabatini LM, Azen EA |title=Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2). |journal=Biochem. Biophys. Res. Commun. |volume=160 |issue= 2 |pages= 495–502 |year= 1989 |pmid= 2719677 |doi=10.1016/0006-291X(89)92460-1 }}<br />
*{{cite journal | author=vanderSpek JC, Wyandt HE, Skare JC, ''et al.'' |title=Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs. | url=https://archive.org/details/sim_american-journal-of-human-genetics_1989-09_45_3/page/381 |journal=Am. J. Hum. Genet. |volume=45 |issue= 3 |pages= 381–7 |year= 1989 |pmid= 2773933 |doi= | pmc=1683406 }}<br />
*{{cite journal | author=Oppenheim FG, Xu T, McMillian FM, ''et al.'' |title=Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans. | url=https://archive.org/details/sim_journal-of-biological-chemistry_1988-06-05_263_16/page/7472 |journal=J. Biol. Chem. |volume=263 |issue= 16 |pages= 7472–7 |year= 1988 |pmid= 3286634 |doi= }}<br />
*{{cite journal | author=Oppenheim FG, Yang YC, Diamond RD, ''et al.'' |title=The primary structure and functional characterization of the neutral histidine-rich polypeptide from human parotid secretion. | url=https://archive.org/details/sim_journal-of-biological-chemistry_1986-01-25_261_3/page/1176 |journal=J. Biol. Chem. |volume=261 |issue= 3 |pages= 1177–82 |year= 1986 |pmid= 3944083 |doi= }}<br />
*{{cite journal | author=Sabatini LM, Ota T, Azen EA |title=Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family. | url=https://archive.org/details/sim_molecular-biology-and-evolution_1993-05_10_3/page/497 |journal=Mol. Biol. Evol. |volume=10 |issue= 3 |pages= 497–511 |year= 1993 |pmid= 8336540 |doi= }}<br />
*{{cite journal | author=Driscoll J, Zuo Y, Xu T, ''et al.'' |title=Functional comparison of native and recombinant human salivary histatin 1. |journal=J. Dent. Res. |volume=74 |issue= 12 |pages= 1837–44 |year= 1996 |pmid= 8600179 |doi= 10.1177/00220345950740120601}}<br />
*{{cite journal | author=Iontcheva I, Oppenheim FG, Offner GD, Troxler RF |title=Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system. |journal=J. Dent. Res. |volume=79 |issue= 2 |pages= 732–9 |year= 2000 |pmid= 10728974 |doi=10.1177/00220345000790020601 }}<br />
*{{cite journal | author=Flora B, Gusman H, Helmerhorst EJ, ''et al.'' |title=A new method for the isolation of histatins 1, 3, and 5 from parotid secretion using zinc precipitation. |journal=Protein Expr. Purif. |volume=23 |issue= 1 |pages= 198–206 |year= 2002 |pmid= 11570863 |doi= 10.1006/prep.2001.1493 }}<br />
*{{cite journal | author=Tamaki N, Tada T, Morita M, Watanabe T |title=Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1. |journal=Calcif. Tissue Int. |volume=71 |issue= 1 |pages= 59–62 |year= 2003 |pmid= 12060866 |doi= 10.1007/s00223-001-1084-0 }}<br />
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}<br />
*{{cite journal | author=Yin A, Margolis HC, Grogan J, ''et al.'' |title=Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins. |journal=Arch. Oral Biol. |volume=48 |issue= 5 |pages= 361–8 |year= 2003 |pmid= 12711380 |doi=10.1016/S0003-9969(03)00012-8 }}<br />
*{{cite journal | author=Michels AA, Nguyen VT, Fraldi A, ''et al.'' |title=MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. | url=https://archive.org/details/sim_molecular-and-cellular-biology_2003-07_23_14/page/4859 |journal=Mol. Cell. Biol. |volume=23 |issue= 14 |pages= 4859–69 |year= 2003 |pmid= 12832472 |doi=10.1128/MCB.23.14.4859-4869.2003 | pmc=162212 }}<br />
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}<br />
*{{cite journal | author=Bruno LS, Li X, Wang L, ''et al.'' |title=Two-hybrid analysis of human salivary mucin MUC7 interactions. |journal=Biochim. Biophys. Acta |volume=1746 |issue= 1 |pages= 65–72 |year= 2005 |pmid= 16203048 |doi= 10.1016/j.bbamcr.2005.08.007 }}<br />
*{{cite journal | author=Cabras T, Fanali C, Monteiro JA, ''et al.'' |title=Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland. |journal=J. Proteome Res. |volume=6 |issue= 7 |pages= 2472–80 |year= 2007 |pmid= 17503797 |doi= 10.1021/pr0700706 }}<br />
}}<br />
{{refend}}<br />
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[[Category:抗微生物肽]]</div>
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