https://arolstar52-zhtest.hf.space/index.php?action=history&feed=atom&title=HADHB
HADHB - 版本历史
2026-07-18T02:22:22Z
在这个wiki上该页的修订历史
MediaWiki 1.43.9
https://arolstar52-zhtest.hf.space/index.php?title=HADHB&diff=2385350&oldid=prev
imported>InternetArchiveBot：Add 5 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot
2025-10-17T23:52:46Z
<p>Add 5 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (<a href="/index.php?title=User:GreenC_bot&action=edit&redlink=1" class="new" title="User:GreenC bot（页面不存在）">GreenC bot</a></p>
<p><b>新页面</b></p><div>{{Infobox gene}}<br />
'''线粒体三功能酶β亚基'''（{{langx|en|Trifunctional enzyme subunit beta, mitochondrial}}，TP-beta）也被称为'''3-ketoacyl-CoA thiolase'''、'''acetyl-CoA acyltransferase'''或'''beta-ketothiolase''' 是一种由人类[[基因]] ''HADHB'' 所编码的[[酶]]<ref name="entrez">{{cite web| title = Entrez Gene: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3032| accessdate = | archive-date = 2009-10-19| archive-url = https://web.archive.org/web/20091019064425/http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3032| dead-url = no}}</ref>。<br />
<br />
HADHB是[[线粒体三功能蛋白]]的一个亚基，并具有{{le|硫解酶|thiolase}}活性。<br />
==结构==<br />
HADHB基因位于[[2号染色体]]的2p23段<ref name="entrez" />，包括17个外显子，该蛋白化学式为<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P55084@34-474@ |website=web.expasy.org |access-date=2025-06-01}}</ref>：C<sub>2153</sub>H<sub>3424</sub>O<sub>648</sub>N<sub>578</sub>S<sub>22</sub><ref>{{Cite web |title=UniProt |url=https://www.uniprot.org/uniprotkb/P55084/entry |website=UniProt |language=en |access-date=2025-06-01}}</ref>分子量为47.4 kDa，包括474个[[氨基酸]]残基<ref name=COPaKB>]{{cite journal | vauthors = Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P | title = Integration of cardiac proteome biology and medicine by a specialized knowledgebase | journal = Circulation Research | volume = 113 | issue = 9 | pages = 1043–53 | date = October 2013 | pmid = 23965338 | pmc = 4076475 | doi = 10.1161/CIRCRESAHA.113.301151 }}</ref><ref name="url_COPaKB">{{cite web | url = http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=P55084 | work = Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) | title = Trifunctional enzyme subunit beta, mitochondrial | access-date = 2019-07-07 | archive-url = https://web.archive.org/web/20160304110706/http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=P55084 | archive-date = 2016-03-04 | dead-url = yes }}</ref>。<br />
<br />
== 功能 ==<br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
==延伸阅读==<br />
{{refbegin | 2}}<br />
*{{cite journal |author=Wang R, Yang Z, Zhu JM, ''et al.'' |title=[Screening for G1528C mutation in mitochondrial trifunctional protein gene in pregnant women with severe preeclampsia and new born infant]. |journal=Zhonghua Fu Chan Ke Za Zhi |volume=41 |issue= 10 |pages= 672–5 |year= 2006 |pmid= 17199921 |doi= }}<br />
*{{cite journal |author=Aboulaich N, Vainonen JP, StrÃ¥lfors P, Vener AV |title=Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. |journal=Biochem. J. |volume=383 |issue= Pt 2 |pages= 237–48 |year= 2004 |pmid= 15242332 |doi= 10.1042/BJ20040647 |pmc=1134064}}<br />
*{{cite journal |author=Adams DJ, Beveridge DJ, van der Weyden L, ''et al.'' |title=HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. |url=https://archive.org/details/sim_journal-of-biological-chemistry_2003-11-07_278_45/page/44894 |journal=J. Biol. Chem. |volume=278 |issue= 45 |pages= 44894–903 |year= 2003 |pmid= 12933794 |doi= 10.1074/jbc.M307782200 }}<br />
*{{cite journal |author=Spiekerkoetter U, Khuchua Z, Yue Z, ''et al.'' |title=General mitochondrial trifunctional protein (TFP) deficiency as a result of either alpha- or beta-subunit mutations exhibits similar phenotypes because mutations in either subunit alter TFP complex expression and subunit turnover. |journal=Pediatr. Res. |volume=55 |issue= 2 |pages= 190–6 |year= 2004 |pmid= 14630990 |doi= 10.1203/01.PDR.0000103931.80055.06 }}<br />
*{{cite journal |author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129}}<br />
*{{cite journal |author=Bogenhagen DF, Rousseau D, Burke S |title=The layered structure of human mitochondrial DNA nucleoids. |url=https://archive.org/details/sim_journal-of-biological-chemistry_2008-02-08_283_6/page/3664 |journal=J. Biol. Chem. |volume=283 |issue= 6 |pages= 3665–75 |year= 2008 |pmid= 18063578 |doi= 10.1074/jbc.M708444200 }}<br />
*{{cite journal |author=Middleton B |title=The mitochondrial long-chain trifunctional enzyme: 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase and 3-oxoacyl-CoA thiolase. |journal=Biochem. Soc. Trans. |volume=22 |issue= 2 |pages= 427–31 |year= 1994 |pmid= 7958339 |doi= }}<br />
*{{cite journal |author=Zhao Y, Meng XM, Wei YJ, ''et al.'' |title=Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. |journal=J. Mol. Med. |volume=81 |issue= 5 |pages= 297–304 |year= 2003 |pmid= 12721663 |doi= 10.1007/s00109-003-0427-x }}<br />
*{{cite journal |author=Behrends C, Sowa ME, Gygi SP, Harper JW |title=Network organization of the human autophagy system. |url=https://archive.org/details/sim_nature-uk_2010-07-01_466_7302/page/67 |journal=Nature |volume=466 |issue= 7302 |pages= 68–76 |year= 2010 |pmid= 20562859 |doi= 10.1038/nature09204 |pmc=2901998}}<br />
*{{cite journal |author=Purevsuren J, Fukao T, Hasegawa Y, ''et al.'' |title=Clinical and molecular aspects of Japanese patients with mitochondrial trifunctional protein deficiency. |journal=Mol. Genet. Metab. |volume=98 |issue= 4 |pages= 372–7 |year= 2009 |pmid= 19699128 |doi= 10.1016/j.ymgme.2009.07.011 }}<br />
*{{cite journal |author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |url=https://archive.org/details/sim_nature-uk_2005-04-07_434_7034/page/724 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}<br />
*{{cite journal |author=Spiekerkoetter U, Sun B, Khuchua Z, ''et al.'' |title=Molecular and phenotypic heterogeneity in mitochondrial trifunctional protein deficiency due to beta-subunit mutations. |journal=Hum. Mutat. |volume=21 |issue= 6 |pages= 598–607 |year= 2003 |pmid= 12754706 |doi= 10.1002/humu.10211 }}<br />
*{{cite journal |author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}}<br />
*{{cite journal |author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}<br />
*{{cite journal |author=Fould B, Garlatti V, Neumann E, ''et al.'' |title=Structural and functional characterization of the recombinant human mitochondrial trifunctional protein. |journal=Biochemistry |volume=49 |issue= 39 |pages= 8608–17 |year= 2010 |pmid= 20825197 |doi= 10.1021/bi100742w }}<br />
*{{cite journal |author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}}<br />
*{{cite journal |author=Ibdah JA, Tein I, Dionisi-Vici C, ''et al.'' |title=Mild trifunctional protein deficiency is associated with progressive neuropathy and myopathy and suggests a novel genotype-phenotype correlation. |url=https://archive.org/details/sim_journal-of-clinical-investigation_1998-09-15_102_6/page/1192 |journal=J. Clin. Invest. |volume=102 |issue= 6 |pages= 1193–9 |year= 1998 |pmid= 9739053 |doi= 10.1172/JCI2091 }}<br />
*{{cite journal |author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |url=https://archive.org/details/sim_nature-biotechnology_2003-05_21_5/page/566 |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2003 |pmid= 12665801 |doi= 10.1038/nbt810 }}<br />
*{{cite journal |author=Hendrickson SL, Lautenberger JA, Chinn LW, ''et al.'' |title=Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. |journal=PLoS ONE |volume=5 |issue= 9 |pages= e12862 |year= 2010 |pmid= 20877624 |doi= 10.1371/journal.pone.0012862 |pmc=2943476}}<br />
*{{cite journal |author=Frackowiak J, Mazur-Kolecka B, Kaczmarski W, Dickson D |title=Deposition of Alzheimer's vascular amyloid-beta is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB). |url=https://archive.org/details/sim_brain-research_2001-07-13_907_1-2/page/n55 |journal=Brain Res. |volume=907 |issue= 1-2 |pages= 44–53 |year= 2001 |pmid= 11430884 |doi= 10.1016/S0006-8993(01)02497-0}}<br />
{{refend}}<br />
<br />
==外部链接==<br />
* {{MeshName|HADHB+protein,+human}}<br />
<br />
{{NLM content}}<br />
{{多酶复合体}}<br />
{{Lipid metabolism enzymes}}<br />
<br />
[[Category:EC 2.3.1]]</div>
imported>InternetArchiveBot