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加入{{Citation style}}标记：引注炸弹

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{{Citation style|time=2025-10-08T09:06:55+00:00}}
{{Infobox drug
| image = H-151_structure.png
| width =


| tradename =
| pregnancy_category =
| routes_of_administration =
| class =
| ATC_prefix =
| ATC_suffix =
| ATC_supplemental =


| legal_status =


| bioavailability =
| protein_bound =
| metabolism =
| metabolites =
| onset =
| elimination_half-life =
| duration_of_action =
| excretion =


| CAS_number = 941987-60-6
| CAS_supplemental =
| PubChem = 7616033
| IUPHAR_ligand =
| DrugBank =
| ChemSpiderID =
| UNII =
| KEGG =
| ChEBI =
| ChEMBL =
| NIAID_ChemDB =
| PDB_ligand =
| synonyms =


| IUPAC_name = 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
| C = 17 | H = 17 | N = 3 | O = 1
| SMILES = CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
| StdInChI = 1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
| StdInChIKey = UJZDIKVQFMCLBE-UHFFFAOYSA-N
}}
'''{{PAGENAME}}'''是一种[[氮化合物|含氮]][[有机化合物]]，分子式[[C17H17N3O|{{chem2|C17H17N3O}}]]，可作为[[干扰素基因刺激蛋白]]（STING）的[[酶抑制剂#不可逆性抑制剂|不可逆抑制剂]]。<ref>{{cite journal | vauthors = Haag SM, Gulen MF, Reymond L, Gibelin A, Abrami L, Decout A, Heymann M, van der Goot FG, Turcatti G, Behrendt R, Ablasser A | title = Targeting STING with covalent small-molecule inhibitors | journal = Nature | volume = 559 | issue = 7713 | pages = 269–273 | date = July 2018 | doi = 10.1038/s41586-018-0287-8 | pmid = 29973723 | bibcode = 2018Natur.559..269H }}</ref><ref>{{cite journal | vauthors = Liu Y, Lu X, Qin N, Qiao Y, Xing S, Liu W, Feng F, Liu Z, Sun H | title = STING, a promising target for small molecular immune modulator: A review | journal = European Journal of Medicinal Chemistry | volume = 211 | pages = 113113 | date = February 2021 | doi = 10.1016/j.ejmech.2020.113113 | pmid = 33360799 }}</ref><ref>{{cite journal | vauthors = Domizio JD, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, Nass T, Guenova E, Schaller M, Conrad C, Goepfert C, de Leval L, Garnier CV, Berezowska S, Dubois A, Gilliet M, Ablasser A | title = The cGAS-STING pathway drives type I IFN immunopathology in COVID-19 | journal = Nature | volume = 603 | issue = 7899 | pages = 145–151 | date = March 2022 | doi = 10.1038/s41586-022-04421-w | pmid = 35045565 | pmc = 8891013 | bibcode = 2022Natur.603..145D }}</ref><ref>{{cite journal | vauthors = Kobritz M, Borjas T, Patel V, Coppa G, Aziz M, Wang P | title = H151, A Small Molecule Inhibitor of Sting as a Novel Therapeutic in Intestinal Ischemia-Reperfusion Injury | journal = Shock | volume = 58 | issue = 3 | pages = 241–250 | date = September 2022 | doi = 10.1097/SHK.0000000000001968 | pmid = 35959789 | pmc = 9489661 }}</ref><ref>{{cite journal | vauthors = Zhao J, Xiao R, Zeng R, He E, Zhang A | title = Small molecules targeting cGAS-STING pathway for autoimmune disease | journal = European Journal of Medicinal Chemistry | volume = 238 | pages = 114480 | date = August 2022 | doi = 10.1016/j.ejmech.2022.114480 | pmid = 35635952 }}</ref><ref>{{cite journal | vauthors = Wu G, Zhang Y, Niu L, Hu Y, Yang Y, Zhao Y | title = Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway | journal = Virus Research | volume = 343 | pages = 199344 | date = May 2024 | doi = 10.1016/j.virusres.2024.199344 | pmid = 38431054 | pmc = 10982080 }}</ref><ref>{{cite journal | vauthors = Tanaka M, Yasuda H, Nakamura S, Shimazawa M | title = H-151, a Selective STING Inhibitor, Has Potential as a Treatment for Neovascular Age-Related Macular Degeneration | journal = Investigative Ophthalmology & Visual Science | volume = 65 | issue = 8 | pages = 16 | date = July 2024 | doi = 10.1167/iovs.65.8.16 | pmid = 38980271 | pmc = 11235146 }}</ref><ref>{{cite journal | vauthors = Ge X, Liu Q, Fan H, Yu H, Li J, Li Y, Qin B, Ma J, Wang J, Hu Y | title = STING facilitates the development of radiation-induced lung injury via regulating the PERK/eIF2α pathway | journal = Translational Lung Cancer Research | volume = 13 | issue = 11 | pages = 3010–3025 | date = November 2024 | doi = 10.21037/tlcr-24-649 | doi-access = free | pmid = 39670000 | pmc = 11632424 }}</ref><ref>{{cite journal | vauthors = Xia L, Jiang JH, Liu JY, Zhang TY, Dong YX, Liu QH, Chai YF, Liu YC, Shou ST | title = H-151 attenuates lipopolysaccharide-induced acute kidney injury by inhibiting the STING-TBK1 pathway | journal = Renal Failure | volume = 46 | issue = 2 | pages = 2363591 | date = December 2024 | doi = 10.1080/0886022X.2024.2363591 | pmid = 38856314 | pmc = 11168233 }}</ref><ref>{{cite journal | vauthors = Liu Z, Qin Q, Wang S, Kang X, Liu Y, Wei L, Lu Z, Cai W, Hu M | title = STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions | journal = CNS Neuroscience & Therapeutics | volume = 30 | issue = 12 | pages = e70106 | date = December 2024 | doi = 10.1111/cns.70106 | pmid = 39698742 | pmc = 11656094 }}</ref><ref>{{cite journal | vauthors = Sun Y, Zou S, Xu X, Xu S, Sun H, Tang M, Kong W, Chen X, He Z | title = Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage | journal = Neuroscience Bulletin | volume = 41 | issue = 3 | pages = 359–373 | date = March 2025 | doi = 10.1007/s12264-024-01334-8 | pmid = 39676140 | pmc = 11876498 }}</ref>

==参考文献==
{{reflist}}

[[Category:试验药物]]
[[Category:吲哚]]
[[Category:脲]]
[[Category:苯甲酰胺]]
[[Category:乙基化合物]]

H-151 - 版本历史

imported>Kurgenera：​加入{{Citation style}}标记：引注炸弹

imported>Kurgenera：加入{{Citation style}}标记：引注炸弹