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Gcn4 - 版本历史
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'''Gcn4'''是[[釀酒酵母]]（''S. cerevisiae''）中的一种[[转录因子]]，是[[酵母]][[基因组]]中的“主调节因子”（"master regulator"），调节接近十分之一的酵母基因组。<br />
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在Razaghi等人的一项研究中，氨基酸饥饿实验激活了转录因子Gcn4，导致几乎所有参与[[氨基酸合成|氨基酸生物合成]]的基因都被诱导转录，包括[[组氨醇脱氢酶]]基因 ''HIS4''和[[Γ-干扰素]]基因 ''hIFNγ'' <ref name="auto">{{cite journal|url=http://www.degruyter.com/view/j/afpuc.2015.62.issue-2/afpuc-2015-0031/afpuc-2015-0031.xml|title=Increased expression and secretion of recombinant hIFNγ through amino acid starvation-induced selective pressure on the adjacent HIS4 gene in Pichia pastoris|first1=Ali|last1=Razaghi|first2=Roger|last2=Huerlimann|first3=Leigh|last3=Owens|first4=Kirsten|last4=Heimann|date=1 December 2015|journal=Acta Facultatis Pharmaceuticae Universitatis Comenianae|volume=62|issue=2|pages=43–50|doi=10.1515/afpuc-2015-0031|access-date=2020-12-02|archive-date=2017-07-08|archive-url=https://web.archive.org/web/20170708164351/https://www.degruyter.com/view/j/afpuc.2015.62.issue-2/afpuc-2015-0031/afpuc-2015-0031.xml|dead-url=no}}</ref>。<br />
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Gcn4是一种高度保守蛋白，其在[[哺乳动物]]中的同源物是{{le|转录激活因子|Activating transcription factor}}-4（[[ATF4]]）<ref>{{Cite journal | doi=10.1002/iub.1090| pmid=23129244| title=New functions of protein kinase Gcn2 in yeast and mammals| journal=IUBMB Life| volume=64| issue=12| pages=971–974| year=2012| last1=Murguía| first1=José R.| last2=Serrano| first2=Ramón}}</ref>。<br />
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==参考文献==<br />
{{Reflist|2}}<br />
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==外部链接==<br />
*{{Cite journal |doi = 10.1038/s41467-017-00539-y|pmid = 28878244|pmc = 5587724|title = The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan|journal = Nature Communications|volume = 8|issue = 1|pages = 457|year = 2017|last1 = Mittal|first1 = Nitish|last2 = Guimaraes|first2 = Joao C.|last3 = Gross|first3 = Thomas|last4 = Schmidt|first4 = Alexander|last5 = Vina-Vilaseca|first5 = Arnau|last6 = Nedialkova|first6 = Danny D.|last7 = Aeschimann|first7 = Florian|last8 = Leidel|first8 = Sebastian A.|last9 = Spang|first9 = Anne|last10 = Zavolan|first10 = Mihaela|bibcode = 2017NatCo...8..457M}}<br />
*{{Cite journal |doi = 10.1080/19491034.2016.1212797|pmid = 27442220|title = Transcription factors dynamically control the spatial organization of the yeast genome|journal = Nucleus|volume = 7|issue = 4|pages = 369–374|year = 2016|last1 = Randise-Hinchliff|first1 = Carlo|last2 = Brickner|first2 = Jason H.|pmc = 5039007}}<br />
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{{Transcription factors|g1}}<br />
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[[Category:转录因子]]<br />
[[Category:真菌基因]]<br />
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{{protein-stub}}</div>
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