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GNA - 版本历史
2026-07-18T14:19:55Z
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2026年4月1日 (三) 04:06 imported>JimGrassroot
2026-04-01T04:06:47Z
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<p><b>新页面</b></p><div>{{About|一种生物化学物质|这个词所指的韩国流行音乐女歌手|G.NA}}<br />
[[File:GNA-T vs. natural DNA-T.png|thumb|upright=1.5|GNA中[[胸腺嘧啶|T]]殘基（紅色）與DNA中天然T[[核苷酸]]（藍色）骨架的比較]]<br />
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'''GNA'''全名'''Glycerol nucleic acid'''，中文直譯'''甘油核酸'''。是一種與[[DNA]]或[[RNA]]相似的化學物質，但組成物有所不同。並不存在任何目前已知的自然界生物體內。<br />
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DNA和RNA分別以[[脫氧核糖]]和[[核糖]]為骨架，而GNA的骨架則由重複的[[乙二醇]](甘油)單元以[[磷酸二酯鍵]]連接而成。雖然甘油分子只有3個[[碳]]原子，但GNA仍然可比表現出[[碱基对|沃森-克-{里}-克鹼基配對]]（A對T；G對C），而且比起DNA與RNA，GNA的鹼基配對更為穩定，需要極高的融解溫度（''Tm''）才能解開。 GNA可能是最簡單的核酸，因此被認為是RNA的假想前驅物。{{citation needed|date=September 2024}}<br />
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== 參考文獻 ==<br />
*{{cite journal en |author=Zhang Lilu, Peritz Adam, Meggers Eric |title=A simple glycol nucleic acid |journal=J Am Chem Soc |volume=127 |issue=12 |pages=4174-5 |year=2005 |url=http://www.sas.upenn.edu/~meggers/pdf/JACS2005_2.pdf |pmid=15783191 |deadurl=yes |archiveurl=https://web.archive.org/web/20070106113124/http://www.sas.upenn.edu/~meggers/pdf/JACS2005_2.pdf |archivedate=2007-01-06 |access-date=2007-07-25 }}<br />
*Seita, Tooru; Yamauchi, Kiyoshi; Kinoshita, Masayoshi; Imoto, Minoru. Condensation polymerization of nucleotide analogues. Die Makromolekulare Chemie (1972), 154:255-261. <br />
*Ueda, Nasuo; Kawabata, Toshio; Takemoto, Kiichi. Synthesis of N-(2,3-dihydroxypropyl) derivatives of nucleic bases. Journal of Heterocyclic Chemistry (1971), 8(5), 827-9.<br />
*Acevedo, Oscar L.; Andrews, Robert S. Synthesis of propane-2,3-diol combinatorial monomers. Tetrahedron Letters (1996), 37(23), 3931-3934.<br />
*Cook, Phillip Dan; Acevedo, Oscar L.; Davis, Peter W.; Ecker, David J.; Hebert, Normand. Synthesis of acyclic oligonucleotides as antiviral and antiinflammatory agents and inhibitors of phospholipase A2. PCT Int. Appl. (1995), 126 pp. WO 9518820 A1 19950713 CAN 124:30276 AN 1995:982328<br />
*Cook, Phillip Dan; Acevedo, Oscar L.; Davis, Peter W.; Ecker, David J.; Hebert, Normand. Preparation of ethylene glycol phosphate linked oligodeoxyribonucleotides as phospholipase A2 inhibitors. U.S. (1999), 39 pp., Cont.-in-part of U.S. Ser. No. 179,970. CODEN: USXXAM US 5886177 A 19990323 CAN 130:237811 AN 1999:205354<br />
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== 外部連結 ==<br />
*[https://web.archive.org/web/20070208114031/http://www.sas.upenn.edu/~meggers/research/GNA.html Meggers Laboratory]<br />
*[http://pubs.acs.org/cen/news/83/i12/8312notw8.html Simpler than DNA]{{Wayback|url=http://pubs.acs.org/cen/news/83/i12/8312notw8.html |date=20070926215238 }} - Chemical and engineering news<br />
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{{Nucleic_acids}}<br />
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[[Category:核酸]]</div>
imported>JimGrassroot