https://arolstar52-zhtest.hf.space/index.php?action=history&feed=atom&title=FOSBFOSB - 版本历史2026-07-02T19:40:58Z在这个wiki上该页的修订历史MediaWiki 1.43.8https://arolstar52-zhtest.hf.space/index.php?title=FOSB&diff=2907421&oldid=previmported>Cdip150 来自 2022年8月30日 (二) 16:402022-08-30T16:40:23Z<p></p>
<p><b>新页面</b></p><div>{{Expand English | FOSB | time=2017-07-10T08:04:01+00:00}}<br />
{{rough translation|data=2017-07-12}}<br />
{{Infobox_gene}}<br />
{{ctm}}<br />
'''FBJ murine osteosarcoma viral oncogene homolog B''',又名為'''FOSB''' 或 '''FosB'''，是一個在人體中由''FOSB'' [[基因]]編碼（encoded）的[[蛋白質]]。<br />
<!--'''FBJ murine osteosarcoma viral oncogene homolog B''', also known as '''FOSB''' or '''FosB''', is a [[蛋白质|protein]] that, in humans, is encoded by the ''FOSB'' [[基因|gene]].-->{{refGT|name=entrez|1={{cite web| title = Entrez Gene: FOSB FBJ murine osteosarcoma viral oncogene homolog B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2354| accessdate = | archive-date = 2019-10-16| archive-url = https://web.archive.org/web/20191016162005/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2354| dead-url = no}}}}{{refGT|name=pmid1702972|1={{cite journal | vauthors = Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR | title = A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes | journal = DNA and Cell Biology | volume = 9 | issue = 8 | pages = 579–87 | date = Oct 1990 | pmid = 1702972 | doi = 10.1089/dna.1990.9.579 }}}}{{refGT|name=pmid1301997|1={{cite journal | vauthors = Martin-Gallardo A, McCombie WR, Gocayne JD, FitzGerald MG, Wallace S, Lee BM, Lamerdin J, Trapp S, Kelley JM, Liu LI | title = Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3 | journal = Nature Genetics | volume = 1 | issue = 1 | pages = 34–9 | date = Apr 1992 | pmid = 1301997 | doi = 10.1038/ng0492-34 }}}}FOS 基因家族由四個成員組成：{{tsl|en|C-Fos||FOS}}、 FOSB、 {{tsl|en|FOSL1||FOSL1}}、和{{tsl|en|FOSL2||FOSL2}}。<br />
<!--The FOS gene family consists of 4 members: {{tsl|en|C-Fos||FOS}}, FOSB, {{tsl|en|FOSL1||FOSL1}}, and {{tsl|en|FOSL2||FOSL2}}.--> <br />
這些基因組成（encode） [[亮氨酸拉链]]（leucine zipper）[[蛋白質]]。這種蛋白質可以與{{tsl|en|C-jun||JUN}} 這個蛋白質及其家族 (e.g., {{tsl|en|c-Jun||c-Jun}}、{{tsl|en|JunD||JunD}}) [[二聚體|二聚體化]]（dimerize），然後形成[[转录因子]]（transcription factor）綜合區－[[AP-1转录因子]]{{noteGT|name=|1=原文：hese genes encode [[亮氨酸拉链|leucine zipper]] proteins that can [[二聚體|dimerize]] with proteins of the {{tsl|en|C-jun||JUN}} family (e.g., {{tsl|en|c-Jun||c-Jun}}, {{tsl|en|JunD||JunD}}), thereby forming the [[转录因子|transcription factor]] complex [[AP-1转录因子|AP-1]].}}。<br />
<!--These genes encode [[亮氨酸拉链|leucine zipper]] proteins that can [[二聚體|dimerize]] with proteins of the {{tsl|en|C-jun||JUN}} family (e.g., {{tsl|en|c-Jun||c-Jun}}, {{tsl|en|JunD||JunD}}), thereby forming the [[转录因子|transcription factor]] complex [[AP-1转录因子|AP-1]].--> <br />
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如同這些，FOS蛋白質就被表示成關於細胞增加、細胞差異化、細胞轉型的調節者。<br />
{{noteGT|name=|1=原文：As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.}}{{refGT|name=entrez}} <br />
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FosB与其[[選擇性剪接]]形成的产物——“ΔFosB”和进一步剪接而成的“'Δ2ΔFosB”都参与到了{{tsl|en|osteosclerosis|骨硬化}}的过程之中，但 Δ2ΔFosB 没有已知的{{tsl|en|transactivation domain|转录活化区域}}，无法通过AP-1 复合物影响[[转录]]过程。{{refGT|name=Δ2ΔFosB transactivation osteoclast|1={{cite journal | vauthors = Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R | title = Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity | journal = Journal of Bone and Mineral Research | volume = 23 | issue = 5 | pages = 584–95 | date = 2008-05 | pmid = 18433296 | pmc = 2674536 | doi = 10.1359/jbmr.080110 }}}}<br />
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現已知ΔFosB之{{tsl|en|splice|端點銜接處}}的{{tsl|en|Variant_of_uncertain_significance|variant|變化程度}}是發展並維持[[病理学|病理行為]]和[[神经可塑性]]的核心因素（[[充分必要条件|充分且必要]]因素）。而[[病理学|病理行為]]和[[神经可塑性]]都參與了[[行為成癮]]（與{{tsl|en|natural reward||自然酬賞}}相關）及[[藥物成癮]]的形成過程。{{refGT|name=What the ΔFosB?|1={{cite journal | vauthors = Ruffle JK | title = Molecular neurobiology of addiction: what's all the (Δ)FosB about? | journal = The American Journal of Drug and Alcohol Abuse | volume = 40 | issue = 6 | pages = 428–37 | date = Nov 2014 | pmid = 25083822 | doi = 10.3109/00952990.2014.933840 | quote = <br />ΔFosB as a therapeutic biomarker<br />The strong correlation between chronic drug exposure and ΔFosB provides novel opportunities for targeted therapies in addiction (118), and suggests methods to analyze their efficacy (119). Over the past two decades, research has progressed from identifying ΔFosB induction to investigating its subsequent action (38). It is likely that ΔFosB research will now progress into a new era – the use of ΔFosB as a biomarker. If ΔFosB detection is indicative of chronic drug exposure (and is at least partly responsible for dependence of the substance), then its monitoring for therapeutic efficacy in interventional studies is a suitable biomarker (Figure 2). Examples of therapeutic avenues are discussed herein.&nbsp;...<br /><br />Conclusions<br />ΔFosB is an essential transcription factor implicated in the molecular and behavioral pathways of addiction following repeated drug exposure. The formation of ΔFosB in multiple brain regions, and the molecular pathway leading to the formation of AP-1 complexes is well understood. The establishment of a functional purpose for ΔFosB has allowed further determination as to some of the key aspects of its molecular cascades, involving effectors such as GluR2 (87,88), Cdk5 (93) and NFkB (100). Moreover, many of these molecular changes identified are now directly linked to the structural, physiological and behavioral changes observed following chronic drug exposure (60,95,97,102). New frontiers of research investigating the molecular roles of ΔFosB have been opened by epigenetic studies, and recent advances have illustrated the role of ΔFosB acting on DNA and histones, truly as a ‘‘molecular switch’’ (34). As a consequence of our improved understanding of ΔFosB in addiction, it is possible to evaluate the addictive potential of current medications (119), as well as use it as a biomarker for assessing the efficacy of therapeutic interventions (121,122,124). Some of these proposed interventions have limitations (125) or are in their infancy (75). However, it is hoped that some of these preliminary findings may lead to innovative treatments, which are much needed in addiction. }}}}<br />
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==註解==<br />
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==參考資料==<br />
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==外部連結==<br />
* [http://neuroscience.mssm.edu/nestler/deltaFosB.html ROLE OF ΔFOSB IN THE NUCLEUS ACCUMBENS]{{Wayback|url=http://neuroscience.mssm.edu/nestler/deltaFosB.html |date=20170628021156 }}<br />
* [http://www.genome.jp/kegg-bin/show_pathway?hsa05034+2354 KEGG Pathway – human alcohol addiction]{{Wayback|url=http://www.genome.jp/kegg-bin/show_pathway?hsa05034+2354 |date=20191112211634 }}<br />
* [http://www.genome.jp/kegg-bin/show_pathway?hsa05031+2354 KEGG Pathway – human amphetamine addiction]{{Wayback|url=http://www.genome.jp/kegg-bin/show_pathway?hsa05031+2354 |date=20180723034121 }}<br />
* [http://www.genome.jp/kegg-bin/show_pathway?hsa05030+2354 KEGG Pathway – human cocaine addiction]{{Wayback|url=http://www.genome.jp/kegg-bin/show_pathway?hsa05030+2354 |date=20170421170322 }}<br />
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==相關條目==<br />
* [[成癮]]<br />
* [[安非他命]]<br />
* {{MeshName|FOSB+protein,+human}}<br />
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相關主題：<br />
{{Related portals2|醫學|神經科學|生物|藥理學}}<br />
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{{NLM content}}<br />
{{Addiction|state=expanded}}<br />
{{Amphetamine}}<br />
{{Transcription factors|g1}}<br />
[[Category:Addiction|Δ0]]<br />
[[Category:Oncogenes]]<br />
[[Category:Transcription factors]]</div>imported>Cdip150