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EXP-561 - 版本历史
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'''EXP-561'''，即'''4-苯基双环[2.2.2]辛-1-胺'''，是一种[[有机化合物]]，化学式为C<sub>14</sub>H<sub>19</sub>N。它可以被3-氯[[过氧苯甲酸]]<!-- CAS: 937-14-4 -->氧化为1-硝基-4-苯基双环[2.2.2]辛烷<!-- CAS: 64852-68-2 -->。<ref>{{cite journal|journal=The Journal of Organic Chemistry|volume=50|issue=7|language=en|issn=0022-3263|date=1985-04|pages=1079–1087|doi=10.1021/jo00207a033|url=https://pubs.acs.org/doi/abs/10.1021/jo00207a033|title=Polar substituent effects on fluorine-19 chemical shifts of aryl and vinyl fluorides: a fluorine-19 nuclear magnetic resonance study of some 1,1-difluoro-2-(4-substituted-bicyclo[2.2.2]oct-1-yl)ethenes|accessdate=2021-05-18|author=William Adcock, Gaik B. Kok}}</ref>在[[碳酸钾]]的存在下，它可以和1-溴-2-甲氧基[[乙烷]]在[[乙腈]]中加热反应，得到''N''-(2-甲氧基乙基)-4-苯基双环[2.2.2]辛-1-胺。<ref>Kick, Ellen K.; Smallheer, Joanne M.; Shaw, Scott A.; Vokits, Benjamin P.; Dilger, Andrew K.; Clark, Charles G.; Valente, Meriah Neissel; Jusuf, Sutjano; Wurtz, Nicholas R. Triazolopyridines as inhibitors of myeloperoxidase and/or eosinophil peroxidase and their preparation. 2017. WO 2017161145 A1.</ref><br />
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1960年代，它被杜邦公司发展<ref>US Patent 3308160 - PHENYLBICYCLO[Z.Z.Z]OCTANE-L-AMINES AND SALTS THEREOF</ref> 并被提名为一种[[抗抑郁药]]，不过失败了<ref>INTERNATIONAL REVIEW NEUROBIOLOGY, Volume 12 Page 160</ref>，也没有上市过。<ref name="pmid2822850">{{cite journal |vauthors=Maj J, Skuza G, Sowińska H, Nowak G | title = Pharmacological properties of EXP 561, a potential antidepressant drug | journal = Journal of Neural Transmission | volume = 70 | issue = 1–2 | pages = 81–97 | year = 1987 | pmid = 2822850 | doi = 10.1007/BF01252511| s2cid = 23469131 }}</ref><ref name="pmid4963065">{{cite journal |vauthors=Lehmann HE, Ban TA, Debow SL | title = A clinical-pharmacological study with EXP 561 | journal = Current Therapeutic Research, Clinical and Experimental | volume = 9 | issue = 6 | pages = 306–8 |date=June 1967 | pmid = 4963065 }}</ref><ref name="pmid5695389">{{cite journal |vauthors=Gershon S, Hekimian LJ, Floyd A | title = Non-correlation of preclinical-clinical evaluation of a prosposed anti-depressant 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561) | journal = Arzneimittel-Forschung | volume = 18 | issue = 2 | pages = 243–5 |date=February 1968 | pmid = 5695389 }}</ref><ref name="pmid474143">{{cite journal |vauthors=Ross SB, Kelder D | title = Inhibition of 3H-dopamine accumulation in reserpinized and normal rat striatum | journal = Acta Pharmacologica et Toxicologica | volume = 44 | issue = 5 | pages = 329–35 |date=May 1979 | pmid = 474143 | doi = 10.1111/j.1600-0773.1979.tb02339.x}}</ref><br />
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==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:胺]]<br />
[[Category:苯基化合物]]<br />
[[Category:桥环烷基化合物]]<br />
[[Category:试验药物]]</div>
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