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ERG5 - 版本历史
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2026年3月9日 (一) 04:26 imported>曦城星月
2026-03-09T04:26:53Z
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<p><b>新页面</b></p><div>{{Infobox nonhuman protein<br />
| Name = Sterol 22-desaturase<br />
| image = <br />
| width = <br />
| caption = <br />
| Organism = Saccharomyces cerevisiae S288c<br />
| TaxID = 559292<br />
| Symbol = ERG5<br />
| AltSymbols = CYP61A1<br />
| EntrezGene = 855029<br />
| HomoloGene = 20212<br />
| PDB = <br />
| RefSeqmRNA = NM_001182511.1<br />
| RefSeqProtein = NP_013728.1<br />
| UniProt = P54781<br />
| ECnumber = 1.14.19.41<br />
| Chromosome = XIII<br />
| EntrezChromosome = NC_001145.3<br />
| GenLoc_start = 300869<br />
| GenLoc_end = 302485<br />
}}<br />
'''ERG5''' 或'''固醇-22-去饱和酶'''（{{langx|en|Sterol 22-desaturase}}）化学式为：C<sub>2842</sub>H<sub>4384</sub>O<sub>782</sub>N<sub>709</sub>S<sub>28</sub>Fe<ref>{{Cite web |title=C-22甾醇去饱和酶ERG5 {{!}} ExpasyProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P54781@1-538@ |website=}}</ref>是[[真菌]][[釀酒酵母]]（''Saccharomyces cerevisiae''）基因组中的一个涉及[[麦角固醇]][[生物合成]]的[[细胞色素P450]][[酶]]，其CYP编号为'''CYP61A1'''<ref>{{cite journal | vauthors = Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS | display-authors = 6 | title = Global analysis of protein expression in yeast | url = https://archive.org/details/sim_nature-uk_2003-10-16_425_6959/page/736 | journal = Nature | volume = 425 | issue = 6959 | pages = 737–41 | date = October 2003 | pmid = 14562106 | doi = 10.1038/nature02046 | bibcode = 2003Natur.425..737G }}</ref>，是釀酒酵母三种细胞色素P450基因之一，另外两种是[[ERG11|CYP51F1]]和[[CYP56A1]]<ref>{{cite journal | vauthors = Nelson DR | title = Cytochrome P450 diversity in the tree of life | journal = Biochimica et Biophysica Acta. Proteins and Proteomics | volume = 1866 | issue = 1 | pages = 141–154 | date = January 2018 | pmid = 28502748 | doi = 10.1016/j.bbapap.2017.05.003 | pmc = 5681887 }}</ref>。ERG5可催化类固醇C17侧链上C22-C23位置[[脱氢]]形成[[双键]]，如麦角固醇生物合成中的[[5-脱氢表甾醇]]（也称为“麦角三烯醇”）转化为[[麦角四烯醇]]，之后麦角四烯醇的C24双键会被酶[[ERG4]][[加氢]]还原为麦角固醇<ref>{{cite journal | vauthors = Kelly SL, Lamb DC, Baldwin BC, Corran AJ, Kelly DE | title = Characterization of Saccharomyces cerevisiae CYP61, sterol delta22-desaturase, and inhibition by azole antifungal agents | url = https://archive.org/details/sim_journal-of-biological-chemistry_1997-04-11_272_15/page/9986 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 15 | pages = 9986–8 | date = April 1997 | pmid = 9092539 | doi = 10.1074/JBC.272.15.9986 }}</ref>。<br />
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== 参考文献 ==<br />
{{Reflist}}<br />
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{{Cytochrome P450}}<br />
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[[Category:细胞色素P450|61]]<br />
[[Category:EC 1.14.19]]<br />
[[Category:真菌基因]]<br />
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{{Enzyme-stub}}</div>
imported>曦城星月