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ERG11 - 版本历史
2026-07-16T15:49:38Z
在这个wiki上该页的修订历史
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imported>曦城星月 来自 2026年1月5日 (一) 10:17
2026-01-05T10:17:01Z
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<p><b>新页面</b></p><div>{{Infobox nonhuman protein<br />
| Name = Sterol 14-demethylase<br />
| image = <br />
| width = <br />
| caption = <br />
| Organism = Saccharomyces cerevisiae<br />
| TaxID = 4932<br />
| Symbol = ERG11<br />
| AltSymbols = CYP51F1<br />
| EntrezGene = 856398<br />
| HomoloGene = 55488<br />
| PDB = <br />
| RefSeqmRNA = NM_001179137<br />
| RefSeqProtein = NP_011871<br />
| UniProt = P10614<br />
| ECnumber = 1.14.14.154<br />
| Chromosome = VIII<br />
| EntrezChromosome = NC_001140<br />
| GenLoc_start = 120091<br />
| GenLoc_end = 121683<br />
}}<br />
'''ERG11'''或'''甾醇-14-去甲基酶'''（Sterol 14-demethylase）是一种[[真菌]][[细胞色素P450]][[酶]]，最初发现于[[酿酒酵母]]（''Saccharomyces cerevisiae''）[[基因组]]，化学式为：C<sub>2810</sub>H<sub>4313</sub>O<sub>771</sub>N<sub>724</sub>S<sub>22</sub>Fe<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P10614@1-530@ |website=web.expasy.org |access-date=2026-01-05}}</ref>，属于CYP51家族，代号'''CYP51F1'''<ref>{{cite journal | vauthors = Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS | display-authors = 6 | title = Global analysis of protein expression in yeast | url = https://archive.org/details/sim_nature-uk_2003-10-16_425_6959/page/736 | journal = Nature | volume = 425 | issue = 6959 | pages = 737–41 | date = October 2003 | pmid = 14562106 | doi = 10.1038/nature02046 | bibcode = 2003Natur.425..737G }}</ref>。ERG11催化[[羊毛甾醇]]转化为[[酵母甾醇]]的第一步，羊毛甾醇的14α-去甲基化生成4,4-二甲基-5α-胆甾-8(9),14,24-三烯-3β-醇，酵母甾醇会进一步生成[[麦角固醇]]<ref>{{cite journal | vauthors = Mo C, Bard M | title = Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex | url = https://archive.org/details/sim_journal-of-lipid-research_2005-09_46_9/page/1991 | journal = Journal of Lipid Research | volume = 46 | issue = 9 | pages = 1991–8 | date = September 2005 | pmid = 15995173 | doi = 10.1194/jlr.M500153-JLR200 }}</ref>。<br />
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== 参考文献 ==<br />
{{Reflist}}<br />
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{{Cytochrome P450}}<br />
<br />
[[Category:细胞色素P450|51]]<br />
[[Category:EC 1.14.14]]<br />
[[Category:真菌基因]]<br />
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{{Enzyme-stub}}</div>
imported>曦城星月