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EPAS1 - 版本历史
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'''内皮PAS结构域包含蛋白-1'''（{{langx|en|Endothelial PAS domain-containing protein 1}}，缩写'''EPAS1'''，也被称为'''缺氧诱导因子-2α亚基'''，{{langx|en|Hypoxia-inducible factor-2alpha}}，缩写'''HIF-2α'''）是一种由人类[[基因]] ''EPAS1'' 所编码的[[蛋白质]]<ref name="pmid9000051">{{cite journal | author = Tian H, McKnight SL, Russell DW | title = Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells | journal = Genes Dev | volume = 11 | issue = 1 | pages = 72–82 | date = Feb 1997 | pmid = 9000051 | pmc = | doi = 10.1101/gad.11.1.72 }}</ref><ref name="pmid9079689">{{cite journal | author = Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA | title = Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway | journal = J Biol Chem | volume = 272 | issue = 13 | pages = 8581–93 | date = May 1997 | pmid = 9079689 | pmc = | doi = 10.1074/jbc.272.13.8581 }}</ref><ref name="pmid18378852">{{cite journal | author = Percy MJ, Beer PA, Campbell G, Dekker AW, Green AR, Oscier D, Rainey MG, van Wijk R, Wood M, Lappin TR, McMullin MF, Lee FS | title = Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis | journal = Blood | volume = 111 | issue = 11 | pages = 5400–2 | date = May 2008 | pmid = 18378852 | pmc = 2396730 | doi = 10.1182/blood-2008-02-137703 }}</ref><ref name = "entrez">{{cite web| title = Entrez Gene: EPAS1 endothelial PAS domain protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2034| accessdate = | archive-date = 2019-10-16| archive-url = https://web.archive.org/web/20191016111035/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2034| dead-url = no}}</ref>。<br />
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== 功能 ==<br />
EPAS1所表达的蛋白是一个[[转录因子]]的组成部分，该转录因子介导一些受[[氧气]]调控基因的表达，特别是低氧（[[缺氧]]）环境下。该蛋白包含一个[[碱性螺旋-环-螺旋]]蛋白二聚化结构域，此结构域也常见于其它氧应激相关信号通路蛋白。EPAS1涉及{{le|胚胎心脏|embryonic heart}}的发育，并在[[脐带]]的[[血管]]壁[[内皮细胞]]中表达。EPAS1维持[[儿茶酚胺]]类物质在胚胎早期发育中的稳定，以防止[[心臟衰竭]]<ref name = "entrez"/>。[[儿茶酚胺]]类物质包括[[肾上腺素]]和[[去甲肾上腺素]]，其稳定对胎儿与成人的心脏的健康有着重要作用<ref name="pmid9808618">{{cite journal | vauthors = Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL | title = The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development | url = https://archive.org/details/sim_genes-development_1998-11-01_12_21/page/3320 | journal = Genes Dev. | volume = 12 | issue = 21 | pages = 3320–4 | date = November 1998 | pmid = 9808618 | pmc = 317225 | doi = 10.1101/gad.12.21.3320 }}</ref>。<br />
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多數[[藏族]]體內含有該基因，讓他們能適應[[藏區]]的低氧環境。該基因源於已滅絕的[[丹尼索瓦人]]，他們與智人交配混血而將該基因''EPAS1''保留下來。<ref>{{cite web |title=尋找其他人類 |url=https://www.natgeomedia.com/e-mag/history/content-17871.html |website=[[國家地理雜誌]] |date=2025-02 |issn=1608-2621}}</ref><br />
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== 交互作用 ==<br />
EPAS1能与{{le|芳香烃受体核转位子|Aryl hydrocarbon receptor nuclear translocator}}<ref name="pmid9079689"/>和[[ARNTL]]<ref name="pmid9576906">{{cite journal | author = Hogenesch JB, Gu YZ, Jain S, Bradfield CA | title = The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 10 | pages = 5474–9 | date = May 1998 | pmid = 9576906 | pmc = 20401 | doi = 10.1073/pnas.95.10.5474 }}</ref>发生[[蛋白質交互作用|交互作用]]。<br />
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== 參考 ==<br />
* {{le|人類的高海拔適應|High-altitude adaptation in humans}}<br />
* [[丹尼索瓦人]]<br />
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==註釋==<br />
{{reflist|2}}<br />
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== 参考文献==<br />
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== 延伸阅读 ==<br />
{{refbegin|2}}<br />
*{{cite journal | author = Brahimi-Horn MC, Pouysségur J | title = The hypoxia-inducible factor and tumor progression along the angiogenic pathway. | journal = Int. Rev. Cytol. | volume = 242 | issue = | pages = 157–213 | year = 2005 | pmid = 15598469 | doi = 10.1016/S0074-7696(04)42004-X }}<br />
*{{cite journal | author = Haase VH | title = Hypoxia-inducible factors in the kidney. | journal = Am. J. Physiol. Renal Physiol. | volume = 291 | issue = 2 | pages = F271–81 | year = 2006 | pmid = 16554418 | doi = 10.1152/ajprenal.00071.2006 }}<br />
*{{cite journal | author = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction. | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}<br />
*{{cite journal | author = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing. | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}<br />
*{{cite journal | author = Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y | title = A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 9 | pages = 4273–8 | year = 1997 | pmid = 9113979 | pmc = 20712 | doi = 10.1073/pnas.94.9.4273 }}<br />
*{{cite journal | author = Hogenesch JB, Gu YZ, Jain S, Bradfield CA | title = The basic helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 10 | pages = 5474–9 | year = 1998 | pmid = 9576906 | pmc = 20401 | doi = 10.1073/pnas.95.10.5474 }}<br />
*{{cite journal | author = Takahata S, Sogawa K, Kobayashi A, Ema M, Mimura J, Ozaki N, Fujii-Kuriyama Y | title = Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. | journal = Biochem. Biophys. Res. Commun. | volume = 248 | issue = 3 | pages = 789–94 | year = 1998 | pmid = 9704006 | doi = 10.1006/bbrc.1998.9012 }}<br />
*{{cite journal | author = Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y | title = Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. | url = https://archive.org/details/sim_embo-journal_1999-04-01_18_7/page/1904 | journal = EMBO J. | volume = 18 | issue = 7 | pages = 1905–14 | year = 1999 | pmid = 10202154 | pmc = 1171276 | doi = 10.1093/emboj/18.7.1905 }}<br />
*{{cite journal | author = Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH | title = Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. | url = https://archive.org/details/sim_journal-of-biological-chemistry_2000-08-18_275_33/page/25732 | journal = J. Biol. Chem. | volume = 275 | issue = 33 | pages = 25733–41 | year = 2000 | pmid = 10823831 | doi = 10.1074/jbc.M002740200 }}<br />
*{{cite journal | author = Maemura K, de la Monte SM, Chin MT, Layne MD, Hsieh CM, Yet SF, Perrella MA, Lee ME | title = CLIF, a novel cycle-like factor, regulates the circadian oscillation of plasminogen activator inhibitor-1 gene expression. | journal = J. Biol. Chem. | volume = 275 | issue = 47 | pages = 36847–51 | year = 2001 | pmid = 11018023 | doi = 10.1074/jbc.C000629200 }}<br />
*{{cite journal | author = Luo JC, Shibuya M | title = A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha). | journal = Oncogene | volume = 20 | issue = 12 | pages = 1435–44 | year = 2001 | pmid = 11313887 | doi = 10.1038/sj.onc.1204228 }}<br />
*{{cite journal | author = Woods SL, Whitelaw ML | title = Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors. | url = https://archive.org/details/sim_journal-of-biological-chemistry_2002-03-22_277_12/page/10236 | journal = J. Biol. Chem. | volume = 277 | issue = 12 | pages = 10236–43 | year = 2002 | pmid = 11782478 | doi = 10.1074/jbc.M110752200 }}<br />
*{{cite journal | author = Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML | title = Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. | url = https://archive.org/details/sim_science_2002-02-01_295_5556/page/858 | journal = Science | volume = 295 | issue = 5556 | pages = 858–61 | year = 2002 | pmid = 11823643 | doi = 10.1126/science.1068592 }}<br />
*{{cite journal | author = Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH | title = Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex. | journal = Adv. Enzyme Regul. | volume = 42 | issue = | pages = 333–47 | year = 2002 | pmid = 12123724 | doi = 10.1016/S0065-2571(01)00037-1 }}<br />
*{{cite journal | author = Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI | title = Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. | url = https://archive.org/details/sim_cancer_2002-09-01_95_5/page/n128 | journal = Cancer | volume = 95 | issue = 5 | pages = 1055–63 | year = 2002 | pmid = 12209691 | doi = 10.1002/cncr.10774 }}<br />
*{{cite journal | author = Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, Rauter M, Plate K, Sieweke M, Breier G, Flamme I | title = Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-02-28_278_9/page/7520 | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 7520–30 | year = 2003 | pmid = 12464608 | doi = 10.1074/jbc.M211298200 }}<br />
*{{cite journal | author = Sang N, Stiehl DP, Bohensky J, Leshchinsky I, Srinivas V, Caro J | title = MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-04-18_278_16/page/14013 | journal = J. Biol. Chem. | volume = 278 | issue = 16 | pages = 14013–9 | year = 2003 | pmid = 12588875 | doi = 10.1074/jbc.M209702200 }}<br />
{{refend}}<br />
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== 外部链接 ==<br />
* {{MeshName|EPAS1+protein,+human}}<br />
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{{PDB Gallery|geneid=2034}}<br />
{{Transcription factors|g1}}<br />
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[[Category:转录因子]]</div>
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