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ELB-139 - 版本历史
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<p><b>新页面</b></p><div>{{Drugbox<br />
| verifiedrevid = 451925233<br />
| IUPAC_name = 1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-one<br />
| image = ELB-139.png<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --><br />
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --><br />
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --><br />
| legal_status = <br />
| routes_of_administration =<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion =<br />
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<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|??}}<br />
| CAS_number = 188116-08-7<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = BKP2A5554F<br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| PubChem = 11277418<br />
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}<br />
| DrugBank = <br />
| ChemSpiderID = 9452418<br />
<br />
<!--Chemical data--><br />
| C=14 | H=16 | Cl=1 | N=3 | O=1 <br />
| smiles = Clc3ccc(cc3)N1CC(=NC1=O)N2CCCCC2<br />
| StdInChI = 1S/C14H16ClN3O/c15-11-4-6-12(7-5-11)18-10-13(16-14(18)19)17-8-2-1-3-9-17/h4-7H,1-3,8-10H2<br />
| StdInChIKey = YGXIELIREXEJQN-UHFFFAOYSA-N<br />
}}<br />
'''{{PAGENAME}}'''或'''LS-191,811'''是一种含氮[[有机氯化合物]]，化学式[[C14H16ClN3O|{{chem2|C14H16ClN3O}}]]，能作为[[非苯二氮䓬类药物|非苯二氮䓬]]类[[抗焦慮藥]]<ref>{{cite journal | vauthors = Langen B, Egerland U, Bernöster K, Dost R, Unverferth K, Rundfeldt C | title = Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor | url = https://archive.org/details/sim_journal-of-pharmacology-and-experimental-therapeutics_2005-08_314_2/page/716 | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 314 | issue = 2 | pages = 717–24 | date = August 2005 | pmid = 15860576 | doi = 10.1124/jpet.105.084681 | s2cid = 21967108 }}</ref><ref>{{cite journal | vauthors = Atack JR | title = The benzodiazepine binding site of GABA(A) receptors as a target for the development of novel anxiolytics | journal = Expert Opinion on Investigational Drugs | volume = 14 | issue = 5 | pages = 601–18 | date = May 2005 | pmid = 15926867 | doi = 10.1517/13543784.14.5.601 | s2cid = 22793644 }}</ref>。<br />
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它可由1-(4-氯苯基)-2,4-咪唑烷二酮和[[哌啶]]在[[吡啶盐酸盐]]存在下反应制得。<ref>Grunwald, Christian; et al. Synthesis, Pharmacology, and Structure-Activity Relationships of Novel Imidazolones and Pyrrolones as Modulators of GABAA Receptors. Journal of Medicinal Chemistry (2006), 49(6), 1855-1866. {{doi|10.1021/jm0509400}}.</ref><br />
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== 参考文献 ==<br />
{{reflist}}<br />
<br />
==外部链接==<br />
<br />
[[Category:抗焦虑药]]<br />
[[Category:对氯苯基化合物]]<br />
[[Category:咪唑啉]]<br />
[[Category:1-哌啶基化合物]]<br />
[[Category:GABAA受体正向变构调节剂]]</div>
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