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{{PBB|geneid=1959}}
'''早期生长反应蛋白2'''（{{langx|en|'''E'''arly '''g'''rowth '''r'''esponse protein 2}}，'''EGR-2'''）是一个由人类[[基因]]''EGR2''编码的[[蛋白质]]。

EGR2是一个转录因子，包含三个串联的Cys2His2型锌指结构，该基因的多态性与I型[[进行性神经性腓骨肌萎缩症]]有关<ref name="entrez">{{cite web| title = Entrez Gene: EGR2 early growth response 2 (Krox-20 homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1959| accessdate = | archive-date = 2019-10-16| archive-url = https://web.archive.org/web/20191016104226/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1959| dead-url = no}}</ref>。

==参考文献==
{{reflist}}

==延伸阅读==
{{refbegin}}
{{PBB Further reading
| citations =
*{{cite journal | author=Rangnekar VM, Aplin AC, Sukhatme VP |title=The serum and TPA responsive promoter and intron-exon structure of EGR2, a human early growth response gene encoding a zinc finger protein | url=https://archive.org/details/sim_nucleic-acids-research_1990-05-11_18_9/page/2748 |journal=Nucleic Acids Res. |volume=18 |issue= 9 |pages= 2749–57 |year= 1990 |pmid= 2111009 |doi=10.1093/nar/18.9.2749 | pmc=330760 }}
*{{cite journal | author=Chavrier P |title=Structure, chromosome location, and expression of the mouse zinc finger gene Krox-20: multiple gene products and coregulation with the proto-oncogene c-fos | url=https://archive.org/details/sim_molecular-and-cellular-biology_1989-02_9_2/page/787 |journal=Mol. Cell. Biol. |volume=9 |issue= 2 |pages= 787–97 |year= 1989 |pmid= 2496302 |doi= | pmc=362656 | author2=Janssen-Timmen U | author3=Mattéi MG | display-authors=3 | last4=Zerial | first4=M | last5=Bravo | first5=R | last6=Charnay | first6=P }}
*{{cite journal | author=Joseph LJ |title=Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 19 |pages= 7164–8 |year= 1988 |pmid= 3140236 |doi=10.1073/pnas.85.19.7164 | pmc=282144 | author2=Le Beau MM | author3=Jamieson GA | display-authors=3 | last4=Acharya | first4=S | last5=Shows | first5=TB | last6=Rowley | first6=JD | last7=Sukhatme | first7=VP }}
*{{cite journal | author=Topilko P |title=Krox-20 controls myelination in the peripheral nervous system | url=https://archive.org/details/sim_nature-uk_1994-10-27_371_6500/page/796 |journal=Nature |volume=371 |issue= 6500 |pages= 796–9 |year= 1994 |pmid= 7935840 |doi= 10.1038/371796a0 | author2=Schneider-Maunoury S | author3=Levi G | display-authors=3 | last4=Baron-Van Evercooren | first4=Anne | last5=Chennoufi | first5=Amina Ben Younes | last6=Seitanidou | first6=Tania | last7=Babinet | first7=Charles | last8=Charnay | first8=Patrick }}
*{{cite journal | author=Sham MH |title=The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation |journal=Cell |volume=72 |issue= 2 |pages= 183–96 |year= 1993 |pmid= 8093858 |doi=10.1016/0092-8674(93)90659-E | author2=Vesque C | author3=Nonchev S | display-authors=3 | last4=Marshall | first4=Heather | last5=Frain | first5=Monique | last6=Gupta | first6=Romita Das | last7=Whiting | first7=Jenny | last8=Wilkinson | first8=David | last9=Charnay | first9=Patrick }}
*{{cite journal | author=Levi G |title=Role of Krox-20 in endochondral bone formation | url=https://archive.org/details/sim_annals-of-the-new-york-academy-of-sciences_1996_785/page/288 |journal=Ann. N. Y. Acad. Sci. |volume=785 |issue= |pages= 288–91 |year= 1996 |pmid= 8702157 |doi=10.1111/j.1749-6632.1996.tb56286.x | author2=Topilko P | author3=Schneider-Maunoury S | display-authors=3 | last4=Lasagna | first4=Marco | last5=Mantero | first5=Stefano | last6=Pesce | first6=Barbara | last7=Ghersi | first7=Giulio | last8=Cancedda | first8=Ranieri | last9=Charnay | first9=Patrick }}
*{{cite journal | author=Warner LE |title=Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies |journal=Nat. Genet. |volume=18 |issue= 4 |pages= 382–4 |year= 1998 |pmid= 9537424 |doi= 10.1038/ng0498-382 | author2=Mancias P | author3=Butler IJ | display-authors=3 | last4=McDonald | first4=Craig M. | last5=Keppen | first5=Laura | last6=Koob | first6=K. Gene | last7=Lupski | first7=James R. }}
*{{cite journal | author=Warner LE, Svaren J, Milbrandt J, Lupski JR |title=Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies |journal=Hum. Mol. Genet. |volume=8 |issue= 7 |pages= 1245–51 |year= 1999 |pmid= 10369870 |doi=10.1093/hmg/8.7.1245 }}
*{{cite journal | author=Timmerman V |title=Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype | url=https://archive.org/details/sim_neurology_1999-06-10_52_9/page/1826 |journal=Neurology |volume=52 |issue= 9 |pages= 1827–32 |year= 1999 |pmid= 10371530 |doi= | author2=De Jonghe P | author3=Ceuterick C | display-authors=3 | last4=De Vriendt | first4=E | last5=Löfgren | first5=A | last6=Nelis | first6=E | last7=Warner | first7=LE | last8=Lupski | first8=JR | last9=Martin | first9=JJ }}
*{{cite journal | author=Bellone E |title=A novel mutation (D305V) in the early growth response 2 gene is associated with severe Charcot-Marie-Tooth type 1 disease |journal=Hum. Mutat. |volume=14 |issue= 4 |pages= 353–4 |year= 1999 |pmid= 10502832 |doi= 10.1002/(SICI)1098-1004(199910)14:4<353::AID-HUMU17>3.0.CO;2-4 | author2=Di Maria E | author3=Soriani S | display-authors=3 | last4=Varese | first4=Alessandra | last5=Doria | first5=Laura Lamba | last6=Ajmar | first6=Franco | last7=Mandich | first7=Paola }}
*{{cite journal | author=Pareyson D |title=Cranial nerve involvement in CMT disease type 1 due to early growth response 2 gene mutation | url=https://archive.org/details/sim_neurology_2000-04-25_54_8/page/1696 |journal=Neurology |volume=54 |issue= 8 |pages= 1696–8 |year= 2000 |pmid= 10762521 |doi= | author2=Taroni F | author3=Botti S | display-authors=3 | last4=Morbin | first4=M | last5=Baratta | first5=S | last6=Lauria | first6=G | last7=Ciano | first7=C | last8=Sghirlanzoni | first8=A }}
*{{cite journal | author=Gambardella L |title=Pattern of expression of the transcription factor Krox-20 in mouse hair follicle | url=https://archive.org/details/sim_mechanisms-of-development_2000-09_96_2/page/215 |journal=Mech. Dev. |volume=96 |issue= 2 |pages= 215–8 |year= 2000 |pmid= 10960786 |doi=10.1016/S0925-4773(00)00398-1 | author2=Schneider-Maunoury S | author3=Voiculescu O | display-authors=3 | last4=Charnay | first4=Patrick | last5=Barrandon | first5=Yann }}
*{{cite journal | author=Yoshihara T |title=A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot--Marie--Tooth disease type 1 | url=https://archive.org/details/sim_journal-of-the-neurological-sciences_2001-03-01_184_2/page/148 |journal=J. Neurol. Sci. |volume=184 |issue= 2 |pages= 149–53 |year= 2001 |pmid= 11239949 |doi=10.1016/S0022-510X(00)00504-9 | author2=Kanda F | author3=Yamamoto M | display-authors=3 | last4=Ishihara | first4=H | last5=Misu | first5=K | last6=Hattori | first6=N | last7=Chihara | first7=K | last8=Sobue | first8=G }}
*{{cite journal | author=Boerkoel CF |title=EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy |journal=Neurogenetics |volume=3 |issue= 3 |pages= 153–7 |year= 2002 |pmid= 11523566 |doi=10.1007/s100480100107 | author2=Takashima H | author3=Bacino CA | display-authors=3 | last4=Daentl | first4=Donna | last5=Lupski | first5=James }}
*{{cite journal | author=Yang Y |title=HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter | url=https://archive.org/details/sim_journal-of-biological-chemistry_2002-05-31_277_22/page/19482 |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19482–7 |year= 2002 |pmid= 11909874 |doi= 10.1074/jbc.M201687200 | author2=Dong B | author3=Mittelstadt PR | display-authors=3 | last4=Xiao | first4=H | last5=Ashwell | first5=JD }}
*{{cite journal | author=Vandenberghe N |title=Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies |journal=J. Med. Genet. |volume=39 |issue= 12 |pages= e81 |year= 2003 |pmid= 12471219 |doi=10.1136/jmg.39.12.e81 | pmc=1757229 | author2=Upadhyaya M | author3=Gatignol A | display-authors=3 | last4=Boutrand | first4=L | last5=Boucherat | first5=M | last6=Chazot | first6=G | last7=Vandenberghe | first7=A | last8=Latour | first8=P }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
*{{cite journal | author=Musso M |title=Different consequences of EGR2 mutants on the transactivation of human Cx32 promoter |journal=Neurobiol. Dis. |volume=12 |issue= 1 |pages= 89–95 |year= 2003 |pmid= 12609493 |doi=10.1016/S0969-9961(02)00018-9 | author2=Balestra P | author3=Taroni F | display-authors=3 | last4=Bellone | first4=Emilia | last5=Mandich | first5=Paola }}
*{{cite journal | author=Unoki M, Nakamura Y |title=EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK |journal=Oncogene |volume=22 |issue= 14 |pages= 2172–85 |year= 2003 |pmid= 12687019 |doi= 10.1038/sj.onc.1206222 }}
*{{cite journal | author=Numakura C |title=Screening of the early growth response 2 gene in Japanese patients with Charcot-Marie-Tooth disease type 1 |journal=J. Neurol. Sci. |volume=210 |issue= 1–2 |pages= 61–4 |year= 2003 |pmid= 12736090 |doi=10.1016/S0022-510X(03)00028-5 | author2=Shirahata E | author3=Yamashita S | display-authors=3 | last4=Kanai | first4=Masayo | last5=Kijima | first5=Kazuki | last6=Matsuki | first6=Takasumi | last7=Hayasaka | first7=Kiyoshi }}
}}
{{refend}}
{{PDB Gallery|geneid=1959}}

==外部链接==
* [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cmt1 GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 1]{{Wayback|url=http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=cmt1 |date=20100117174706 }}
* [https://www.ncbi.nlm.nih.gov/books/NBK1468/ GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4]{{Wayback|url=https://www.ncbi.nlm.nih.gov/books/NBK1468/ |date=20190215234451 }}
* {{MeshName|EGR2+protein,+human}}

{{NLM content}}
{{Transcription factors|g2}}


{{PBB Controls
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[[Category:转录因子]]

EGR2 - 版本历史

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