https://arolstar52-zhtest.hf.space/index.php?action=history&feed=atom&title=E2F E2F - 版本历史 2026-07-13T21:58:48Z 本wiki上该页面的版本历史 MediaWiki 1.43.9 https://arolstar52-zhtest.hf.space/index.php?title=E2F&diff=3946794&oldid=prev imported>InternetArchiveBot：​Add 1 book for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot 2025-10-17T22:41:57Z <p>Add 1 book for verifiability (20251017sim)) #IABot (v2.0.9.5) (<a href="/index.php?title=User:GreenC_bot&amp;action=edit&amp;redlink=1" class="new" title="User:GreenC bot（页面不存在）">GreenC bot</a></p> <p><b>新页面</b></p><div>&#039;&#039;&#039;E2F&#039;&#039;&#039;是一组编码高等[[真核生物]][[转录因子]]家族的基因。其中三个是激活剂：E2F1,E2F2和E2F3a。其他六个充当抑制剂：E2F3b,E2F4,E2F5,E2F6,E2F7a,E2F7b和E2F8。它们都参与[[哺乳动物]]细胞中DNA的[[細胞週期|细胞周期]]调控和合成。E2F作为转录因子与目标[[啟動子|启动子]]序列中的 TTTCCCGC共有[[结合位点]]结合，TTTCCCGC并不是固定序列，可能存在轻微变化。<br /> <br /> == E2F转录因子家族 ==<br /> E2F 家族成员的[[蛋白質一級結構|氨基酸序列]]示意图（左侧为[[N端|N-端]]，右侧为[[C端|C-端]]）突出显示每个成员中功能[[蛋白质结构域|域]]的相对位置：<br /> {| class=&quot;wikitable&quot;<br /> !家族成员<br /> !文字说明<br /> |-<br /> |<br /> [[File:E2F family member.png|657px]]<br /> |<br /> * &#039;&#039;&#039;cyc A&#039;&#039;&#039; -{{le|周期蛋白A|Cyclin A}}结合结构域<br /> * &#039;&#039;&#039;DNA&#039;&#039;&#039; - {{le|DNA结合结构域|DNA-binding domain}}<br /> * &#039;&#039;&#039;DP1,2&#039;&#039;&#039; - 与[[TFDP1|DP1]]、[[TFDP2|2]]进行二聚化的结构域<br /> * &#039;&#039;&#039;TA&#039;&#039;&#039; - 转录激活结构域<br /> * &#039;&#039;&#039;PB&#039;&#039;&#039; - [[袋状蛋白家族|口袋状蛋白]]结合结构域<br /> |}<br /> <br /> == 基因 ==<br /> 转录因子E2F由人类E2F1基因编码<br /> <br /> == 结构 ==<br /> [[X射线晶体学|X 射线晶体学]]分析表明，E2F 转录因子家族具有类似于翼螺旋DNA 结合基序的[[蛋白质结构|折叠]]。 &lt;ref name=&quot;pmid10090723&quot;&gt;{{Cite journal|title=Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP|url=https://archive.org/details/sim_genes-development_1999-03-15_13_6/page/666|date=March 1999|journal=Genes &amp; Development|issue=6|doi=10.1101/gad.13.6.666|volume=13|pages=666–74|pmc=316551|pmid=10090723}}&lt;/ref&gt;<br /> [[File:Role_of_CDK4,_cyklin_D,_Rb_and_E2F_in_cell_cycle_regulation.jpg|缩略图| 周期蛋白依赖性激酶4、细胞周期蛋白D、Rb 和 E2F 在细胞周期调节中的作用]]<br /> [[File:Signal_transduction_pathways.svg|右|缩略图|300x300像素|涉及[[细胞凋亡]]的信号转导途径概述]]<br /> <br /> ==参考文献==<br /> {{reflist}}<br /> ==外部链接==<br /> * {{MeshName|E2F+Transcription+Factors}}<br /> * [http://www.sdbonline.org/fly/newgene/e2f.htm &#039;&#039;Drosophila&#039;&#039; &#039;&#039;E2F transcription factor&#039;&#039; - The Interactive Fly] {{Wayback|url=http://www.sdbonline.org/fly/newgene/e2f.htm |date=20131210025052 }}<br /> * [http://www.sdbonline.org/fly/newgene/e2fsnd-1.htm &#039;&#039;Drosophila&#039;&#039; &#039;&#039;E2F transcription factor 2&#039;&#039; - The Interactive Fly] {{Wayback|url=http://www.sdbonline.org/fly/newgene/e2fsnd-1.htm |date=20120225214308 }}<br /> {{转录因子与细胞内受体|g3}}<br /> {{细胞周期蛋白质}}<br /> <br /> [[Category:转录因子]]<br /> [[Category:细胞周期]]</div> imported>InternetArchiveBot