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DPH-362 - 版本历史
2026-07-17T19:47:41Z
在这个wiki上该页的修订历史
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2024-11-30T05:42:44Z
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<p><b>新页面</b></p><div>{{Infobox drug<br />
| drug_name = <br />
| INN = <br />
| type = <!-- empty --><br />
| image = DPH-362.svg<br />
| width = 250px<br />
| alt = <br />
| caption = <br />
| image2 = <br />
| width2 = <br />
| alt2 = <br />
| caption2 = <br />
| imageL = <br />
| widthL = <br />
| altL = <br />
| imageR = <br />
| widthR = <br />
| altR = <br />
| captionLR = <br />
<br />
<!-- Clinical data --><br />
| pronounce = <br />
| tradename = <br />
| Drugs.com = <br />
| MedlinePlus = <br />
| licence_CA = <br />
| licence_EU = <br />
| DailyMedID = <br />
| licence_US = <br />
| pregnancy_AU = <br />
| pregnancy_AU_comment = <br />
| pregnancy_category= <br />
| dependency_liability = <br />
| addiction_liability = <br />
| routes_of_administration = <br />
| class = <br />
| ATCvet = <br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| ATC_supplemental = <br />
<br />
<!-- Legal status --><br />
| legal_AU = <br />
| legal_AU_comment = <br />
| legal_BR = <br />
| legal_BR_comment = <br />
| legal_CA = <br />
| legal_CA_comment = <br />
| legal_DE = <br />
| legal_DE_comment = <br />
| legal_NZ = <br />
| legal_NZ_comment = <br />
| legal_UK = <br />
| legal_UK_comment = <br />
| legal_US = <br />
| legal_US_comment = <br />
| legal_EU = <br />
| legal_EU_comment = <br />
| legal_UN = <br />
| legal_UN_comment = <br />
| legal_status = <br />
<br />
<!-- Pharmacokinetic data --><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| metabolites = <br />
| onset = <br />
| elimination_half-life = <br />
| duration_of_action= <br />
| excretion = <br />
<br />
<!-- Identifiers --><br />
| CAS_number = 28916-83-8<br />
| CAS_supplemental = <br />
| PubChem = 13465<br />
| PubChemSubstance = <br />
| IUPHAR_ligand = <br />
| DrugBank = <br />
| ChemSpiderID = 12888<br />
| UNII = <br />
| KEGG = <br />
| ChEBI = <br />
| ChEMBL = <br />
| NIAID_ChemDB = <br />
| PDB_ligand = <br />
| synonyms = PD129167<br />
<br />
<!-- Chemical and physical data --><br />
| IUPAC_name = <nowiki>N,N-dimethyl-4,4-diphenylbut-3-en-1-amine</nowiki><br />
| C=18 | H=21 | N=1<br />
| molecular_weight = <br />
| SMILES = CN(C)CCC=C(C1=CC=CC=C1)C2=CC=CC=C2<br />
| Jmol = <br />
| StdInChI = InChI=1S/C18H21N/c1-19(2)15-9-14-18(16-10-5-3-6-11-16)17-12-7-4-8-13-17/h3-8,10-14H,9,15H2,1-2H3<br />
| StdInChI_comment = <br />
| StdInChIKey = ZRPJJBLGKLVADE-UHFFFAOYSA-N<br />
| density = <br />
| density_notes = <br />
| melting_point = <br />
| melting_high = <br />
| melting_notes = <br />
| boiling_point = <br />
| boiling_notes = <br />
| solubility = <br />
| sol_units = <br />
| specific_rotation = <br />
}}<br />
'''{{PAGENAME}}'''是一种[[氮化合物|含氮]][[有机化合物]]，分子式[[C18H21N|C<sub>18</sub>H<sub>21</sub>N]]，与[[阿米替林]]等[[三环类抗抑郁药]]（TCA）类似，但其中的[[二苯并环庚烯]]变为了[[二苯甲烷]]<ref>{{cite journal | vauthors = Bölcskei H, Tarnawa I, Kocsis P | title = Voltage-gated sodium channel blockers, 2001-2006: An overview. | journal = Medicinal Chemistry Research | date = June 2008 | volume = 17 | issue = 2–7 | pages = 356–368 | doi = 10.1007/s00044-007-9071-2 }}</ref><ref>{{cite journal | vauthors = Hudgens DP, Taylor C, Batts TW, Patel MK, Brown ML | title = Discovery of diphenyl amine based sodium channel blockers, effective against hNav1.2 | journal = Bioorganic & Medicinal Chemistry | volume = 14 | issue = 24 | pages = 8366–8378 | date = December 2006 | pmid = 17035036 | doi = 10.1016/j.bmc.2006.09.010 | pmc = 2756728 }}</ref>，衍生物有[[SKF-89976A]]。<br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:鈉離子通道阻滯劑]]<br />
[[Category:止痛药]]<br />
[[Category:二甲氨基化合物]]</div>
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