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{{Infobox software
|name = CLUSTAL
|developer = {{Plainlist|
* [[德斯蒙德·G·希金斯]]
* Fabian Sievers
* David Dineen
* Andreas Wilm （全为[[都柏林大学 (爱尔兰国立大学)|都柏林大学]]康维研究所员工）}}
|latest release = 1.2.2 ({{release date and age|2016|07|01}})
|operating_system = [[UNIX]]、[[Linux]]、[[Apple Macintosh|MacOS]]、[[Microsoft Windows]]、[[FreeBSD]]、[[Debian]]
|programming language = C++
|genre = 生物信息学工具
|licence = [[GNU General Public License]], version 2<ref>See file COPYING, in source archive [http://www.clustal.org/omega/clustal-omega-1.2.0.tar.gz] {{Wayback|url=http://www.clustal.org/omega/clustal-omega-1.2.0.tar.gz |date=20210612074734 }}. Accessed 2014-01-15.</ref>
|website = {{URL|http://www.clustal.org/omega/}}
}}
[[File:Multiple_Sequence_Alignment_Using_ClustalW.jpg|thumb|400px|由ClustalW执行的多种生物[[周期蛋白依赖性激酶4|CDK4蛋白]]的[[多重序列比對]]，箭头指出位置为[[點突變]]]]
'''Clustal'''是一类用于[[多重序列比對]]的[[生物信息学]][[计算机程序]]<ref name="Chenna2003">{{cite journal | author = Chenna R | author2 = Sugawara H | author3 = Koike T | author4 = Lopez R | author5 = [[Toby Gibson|Gibson TJ]] | author6 = [[Des Higgins|Higgins DG]] | author7 = Thompson JD | title = Multiple sequence alignment with the Clustal series of programs | journal = Nucleic Acids Research | volume = 31 | issue = 13 | pages = 3497–500 | date = July 2003 | pmid = 12824352 | pmc = 168907 | doi = 10.1093/nar/gkg500 }}</ref>。

==版本==
Clustal软件有如下几个版本：

* '''Clustal'''：最早的版本，由[[德斯蒙德·G·希金斯]]在1988年发表<ref name="pmid3243435">{{cite journal | vauthors = Higgins DG, Sharp PM | title = CLUSTAL: a package for performing multiple sequence alignment on a microcomputer | url = https://archive.org/details/sim_gene_1988-12-15_73_1/page/n244 | journal = Gene | volume = 73 | issue = 1 | pages = 237–44 | date = December 1988 | pmid = 3243435 | doi = 10.1016/0378-1119(88)90330-7 }}</ref>
* '''ClustalV'''：Clustal的第二个版本，1992年发布<ref name="pmid1591615">{{cite journal | vauthors = Higgins DG, Bleasby AJ, Fuchs R | title = CLUSTAL V: improved software for multiple sequence alignment | journal = Computer Applications in the Biosciences | volume = 8 | issue = 2 | pages = 189–91 | date = April 1992 | pmid = 1591615 | doi = 10.1093/bioinformatics/8.2.189 }}</ref>
*'''ClustalW'''：Clustal的第三个版本，1994年发布<ref name="pmid3243435" />
*'''ClustalX'''：Clustal的第四个版本，1997年发布<ref name="Thompson1997">{{cite journal | author = Thompson JD | author2 = [[Toby Gibson|Gibson TJ]] | author3 = Plewniak F | author4 = Jeanmougin F | author5 = Higgins DG | title = The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools | journal = Nucleic Acids Research | volume = 25 | issue = 24 | pages = 4876–82 | date = December 1997 | pmid = 9396791 | pmc = 147148 | doi = 10.1093/nar/25.24.4876 }}</ref>
*'''Clustal2'''：Clustal的第五个版本，2007年发布<ref>{{Cite web|url=http://www.clustal.org/clustal2/|title=Clustal W and Clustal X Multiple Sequence Alignment|last=Dineen|first=David|website=www.clustal.org|access-date=2018-04-24|archive-date=2018-04-16|archive-url=https://web.archive.org/web/20180416130735/http://www.clustal.org/clustal2/|url-status=live}}</ref>
*'''ClustalΩ'''：Clustal的第六个版本，2011年发布<ref>{{Cite book|title=Multiple Sequence Alignment Methods|journal=|volume=1079|last1=Sievers|first1=Fabian|last2=Higgins|first2=Desmond G.|chapter=Clustal Omega, Accurate Alignment of Very Large Numbers of Sequences | name-list-style = vanc |date=2014-01-01|publisher=Humana Press|isbn=9781627036450|editor-last=Russell|editor-first=David J|series=Methods in Molecular Biology|pages=105–116|language=en|doi=10.1007/978-1-62703-646-7_6|pmid = 24170397}}</ref><ref>{{Cite book|volume=48|pages=3.13.1–16|last1=Sievers|first1=Fabian|last2=Higgins|first2=Desmond G.| name-list-style = vanc |date=2002-01-01|publisher=John Wiley & Sons, Inc.|isbn=9780471250951|language=en|doi=10.1002/0471250953.bi0313s48|pmid = 25501942|title=Clustal Omega|journal=Current Protocols in Bioinformatics|s2cid=1762688}}</ref>

== 参考资料 ==
{{reflist|25em}}

== 外部链接 ==
*[http://www.clustal.org Clustal Homepage] {{Wayback|url=http://www.clustal.org/ |date=20100529100824 }} (free Unix/Linux, Mac, and Windows download)
*[http://www.ebi.ac.uk/Tools/msa/clustalo/ Clustal Omega mirror at the EBI] {{Wayback|url=http://www.ebi.ac.uk/Tools/msa/clustalo/ |date=20210618144151 }}

{{Bioinformatics}}
[[Category:生物信息學軟件]]
[[Category:計算系統發生學]]

Clustal - 版本历史

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