https://arolstar52-zhtest.hf.space/index.php?action=history&feed=atom&title=CYP51 CYP51 - 版本历史 2026-07-18T06:29:32Z 在这个wiki上该页的修订历史 MediaWiki 1.43.9 https://arolstar52-zhtest.hf.space/index.php?title=CYP51&diff=3413268&oldid=prev imported>Htmlzycq：​/* top */ 2026-04-08T03:06:40Z <p><span class="autocomment">top</span></p> <p><b>新页面</b></p><div>{{infobox enzyme<br /> | Name = sterol 14alpha-demethylase<br /> | EC_number = 1.14.14.154<br /> | CAS_number =<br /> | GO_code = 0008398<br /> | image = <br /> | width = <br /> | caption = <br /> }}<br /> &#039;&#039;&#039;细胞色素P450家族51&#039;&#039;&#039;，&#039;&#039;&#039;CYP51&#039;&#039;&#039;也称为&#039;&#039;&#039;甾醇-14-去甲基酶&#039;&#039;&#039;（{{langx|en|sterol 14-demethylase}}，{{EC number|1.14.14.154}}，旧EC号：1.14.13.70，化学式为：C&lt;sub&gt;2810&lt;/sub&gt;H&lt;sub&gt;4313&lt;/sub&gt;O&lt;sub&gt;771&lt;/sub&gt;N&lt;sub&gt;724&lt;/sub&gt;S&lt;sub&gt;22&lt;/sub&gt;Fe&lt;ref&gt;{{Cite web |title=甾醇-14-去甲基酶(酿酒酵母細胞色素P450家族51) {{!}} Expasy - ProtParam {{!}} (注：计算结果包含血红素辅基，计算严格考虑电荷平衡与分子整体中性) |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P10614@1-530@ |website=web.expasy.org |access-date=2026-03-09}}&lt;/ref&gt;）是[[催化]]一系列14α-甲基甾醇去甲基化的[[酶]]。多种C29、C30[[甾醇]]底物可被CYP51家族的酶去甲基化&lt;ref name=&quot;Lepesheva_2007&quot;&gt;{{cite journal | vauthors = Lepesheva GI, Waterman MR | title = Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms | journal = Biochimica et Biophysica Acta | volume = 1770 | issue = 3 | pages = 467–77 | date = March 2007 | pmid = 16963187 | pmc = 2324071 | doi = 10.1016/j.bbagen.2006.07.018 }}&lt;/ref&gt;，如[[ERG11|CYP51F1]]主要催化：<br /> <br /> :[[钝叶醇]] + 3 O&lt;sub&gt;2&lt;/sub&gt; + 3 [[NADPH]] + 3 H&lt;sup&gt;+&lt;/sup&gt; &lt;math&gt;\rightleftharpoons&lt;/math&gt; 4α-甲基-5α-麦角甾-8,14,24(28)-三烯-3β-ol + [[甲酸]] + 3 NADP&lt;sup&gt;+&lt;/sup&gt; + 4 H&lt;sub&gt;2&lt;/sub&gt;O<br /> <br /> 而[[CYP51A1]]在人体内催化[[2,3-环氧鲨烯]]环化为羊毛甾醇后的第一步反应：<br /> :[[羊毛甾醇]] + 3 O&lt;sub&gt;2&lt;/sub&gt; + 3 NADPH + 3 H&lt;sup&gt;+&lt;/sup&gt; &lt;math&gt;\rightleftharpoons&lt;/math&gt; 4,4-二甲基-5α-胆甾-8(9),14,24-三烯-3β-ol + 甲酸 + 3 NADP&lt;sup&gt;+&lt;/sup&gt; + 4 H&lt;sub&gt;2&lt;/sub&gt;O<br /> <br /> [[File:Lanosterol Demethylation Pathway.png|380px|left|thumb|CYP51A1催化羊毛甾醇三次发生加氧反应，生成对应产物]]<br /> <br /> ==参考文献==<br /> * {{reflist}}<br /> <br /> {{Cytochrome P450}}<br /> <br /> [[Category:EC 1.14.13]]<br /> [[Category:细胞色素P450|51]]</div> imported>Htmlzycq