https://arolstar52-zhtest.hf.space/index.php?action=history&feed=atom&title=CYP46A1 CYP46A1 - 版本历史 2026-07-18T22:47:34Z 本wiki上该页面的版本历史 MediaWiki 1.43.9 https://arolstar52-zhtest.hf.space/index.php?title=CYP46A1&diff=3421365&oldid=prev 2026年1月3日 (六) 11:55 imported>曦城星月 2026-01-03T11:55:58Z <p></p> <p><b>新页面</b></p><div>{{infobox_gene}}<br /> <br /> &#039;&#039;&#039;细胞色素 P450 46A1&#039;&#039;&#039;（{{langx|en|Cytochrome P450 46A1}}，缩写&#039;&#039;&#039;CYP46A1&#039;&#039;&#039;）也被称为&#039;&#039;&#039;胆固醇24-羟化酶&#039;&#039;&#039;（{{lang|en|chilsterol 24-hydroxylase}}，{{EC number|1.14.13.98}}），化学式为：C&lt;sub&gt;2600&lt;/sub&gt;H&lt;sub&gt;4085&lt;/sub&gt;O&lt;sub&gt;716&lt;/sub&gt;N&lt;sub&gt;705&lt;/sub&gt;S&lt;sub&gt;22&lt;/sub&gt;Fe&lt;ref&gt;{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?Q9Y6A2@1-500@ |website=web.expasy.org |access-date=2026-01-03}}&lt;/ref&gt;，是[[细胞色素P450]]超家族的一员，由&#039;&#039;CYP46A1&#039;&#039;基因编码，是催化[[胆固醇]]生成[[羟基化]]生成[[脑甾醇]]（24S-羟基胆固醇）的酶&lt;ref name=&quot;russell2009&quot;&gt;{{Cite journal<br /> |author1=Russell DW |author2=Halford RW |author3=Ramirez DMO |author4=Shah R |author5=Kotti T | title = Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain |url=https://archive.org/details/sim_annual-review-of-biochemistry_2009_78/page/1017 | journal = [[Annual Review of Biochemistry]] | volume = 78 | pages = 1017–1040 | year = 2009 | doi = 10.1146/annurev.biochem.78.072407.103859 | pmid = 19489738 | pmc=2837268}}&lt;/ref&gt;。<br /> {{Infobox enzyme<br /> |name= Cholesterol-24 hydroxylase<br /> |image=Protein CYP46A1 PDB 2Q9F.png<br /> |image_size=220<br /> |caption=Structure of cholesterol-24 hydroxlase (CYP46A1) in &#039;&#039;Homo sapiens&#039;&#039;. Based on PyMOL rendering of PDB {{PDB2|2Q9F}}.<br /> |EC_number=1.14.13.98<br /> }}<br /> <br /> ==参考文献==<br /> {{reflist}}<br /> ==外部链接==<br /> *[https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&amp;part=ctx GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis]{{Wayback|url=https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&amp;part=ctx |date=20100321174316 }}<br /> * {{MeshName|Cytochrome+P-450+CYP27A1}}<br /> * {{UCSC gene info|CYP27A1}}<br /> <br /> {{Cytochrome P450}}<br /> {{双加氧酶类}}<br /> <br /> [[Category:细胞色素P450|46]]</div> imported>曦城星月