imported>Cewbot：Cewbot: 修正維基語法 102: PMID語法錯誤

2026-04-29T00:10:19Z

Cewbot: 修正維基語法 102: PMID語法錯誤

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{{infobox_gene}}

'''细胞色素 P450 27C1'''（cytochrome P450 27C1<ref>Glass SM, Webb SN, Guengerich FP. Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin. Arch Biochem Biophys. 2021 Dec 15;714:109076. doi: 10.1016/j.abb.2021.109076. Epub 2021 Oct 31. PMID 34732331; PMCID: PMC8629852.</ref><ref>Glass SM, Tateishi Y, Guengerich FP, Wang HJ. 3,4-Desaturation of retinoic acid by cytochrome P450 27C1 prevents P450-mediated catabolism. Arch Biochem Biophys. 2023 Jul 15;743:109669. doi: 10.1016/j.abb.2023.109669. Epub 2023 Jun 24. PMID 37356607; PMCID: PMC11500474.</ref>，CYP27C1<ref>Enright JM, Toomey MB, Sato SY, et al. Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2. Curr Biol. 2015 Dec 7;25(23):3048-57. doi: 10.1016/j.cub.2015.10.018. Epub 2015 Nov 5. PMID 26549260; PMCID: PMC4910640.</ref><ref>Morshedian A, Toomey MB, Pollock GE, et al. Cambrian origin of the CYP27C1-mediated vitamin A1-to-A2 switch, a key mechanism of vertebrate sensory plasticity. R Soc Open Sci. 2017 Jul 5;4(7):170362. doi: 10.1098/rsos.170362. PMID 28791166; PMCID: PMC5541561.</ref>），化学式为 C2426H3796O668N677S14Fe<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?Q4G0S4@81-542@ |website=web.expasy.org |access-date=2026-01-05}}</ref>，是[[细胞色素P450]]超家族的一员，由''CYP27C1''基因编码，是定位于许多不同组织[[线粒体内膜]]的[[单加氧酶]]<ref name="pmid14702039">{{cite journal | vauthors = Ota T, Suzuki Y, Nishikawa T | title = Complete sequencing and characterization of 21,243 full-length human cDNAs | journal = Nat. Genet. | volume = 36 | issue = 1 | pages = 40–5 |date=January 2004 | pmid = 14702039 | doi = 10.1038/ng1285 | url = | issn = |display-authors=etal| doi-access = free }}</ref><ref name="pmid15489334">{{cite journal | vauthors = Gerhard DS, Wagner L, Feingold EA | title = The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2121–7 |date=October 2004 | pmid = 15489334 | pmc = 528928 | doi = 10.1101/gr.2596504 | url = | issn = |display-authors=etal}}</ref>。

CYP27C1在[[体内]]的主要功能是将全反式[[视黄醇]]（属于维生素A1）转化为全反式3,4-脱氢[[视黄醛]]（属于[[维生素A2]]）<ref>{{cite journal |last1=Kramlinger |first1=VM |last2=Nagy |first2=LD |last3=Fujiwara |first3=R |last4=Johnson |first4=KM |last5=Phan |first5=TT |last6=Xiao |first6=Y |last7=Enright |first7=JM |last8=Toomey |first8=MB |last9=Corbo |first9=JC |last10=Guengerich |first10=FP |title=Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids. |journal=FEBS letters |date=2016-05 |volume=590 |issue=9 |pages=1304-12 |doi=10.1002/1873-3468.12167 |pmid=27059013}}</ref>；此外还能催化多种反应，如[[胆固醇]]、[[甾体激素]]的合成与代谢<ref name="entrez_2532">{{cite web | title = Entrez Gene: CYP39A1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=339761 | accessdate = | archive-date = 2010-12-05 | archive-url = https://web.archive.org/web/20101205081110/http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene | dead-url = no }}</ref>。

==参考文献==
{{reflist}}
==外部链接==
* {{MeshName|Cytochrome+P-450+CYP27C1}}
* {{UCSC gene info|CYP27C1}}

{{Cytochrome P450}}
{{双加氧酶类}}

[[Category:细胞色素P450|27]]

CYP27C1 - 版本历史

imported>Cewbot：​Cewbot: 修正維基語法 102: PMID語法錯誤

imported>Cewbot：Cewbot: 修正維基語法 102: PMID語法錯誤