2026年1月3日 (六) 11:48 imported>曦城星月

2026-01-03T11:48:17Z

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{{infobox_gene}}

'''细胞色素 P450 27B1'''（{{langx|en|Cytochrome P450 27B1}}，缩写'''CYP27B1'''）也被称为'''25-羟基维生素 D3 1-α-羟化酶'''（{{lang|en|25-Hydroxyvitamin D3 1-alpha-hydroxylase}},化学式为：C2567H4025O707N739S16Fe<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?O15528@noft@ |website=web.expasy.org |access-date=2026-01-03}}</ref>，{{EC number|1.14.15.18}}），是[[细胞色素P450]]超家族的一员，由''CYP27B1''基因编码，定位于[[线粒体内膜]]<ref name="entrez">{{cite web| title = Entrez Gene: cytochrome P450| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1594| accessdate = | archive-date = 2009-05-11| archive-url = https://web.archive.org/web/20090511064646/http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1594| dead-url = no}}</ref><ref name="pmid9295274">{{cite journal | vauthors = Takeyama K, Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S | title = 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis | url = https://archive.org/details/sim_science_1997-09-19_277_5333/page/1826 | journal = Science | volume = 277 | issue = 5333 | pages = 1827–30 | date = Sep 1997 | pmid = 9295274 | doi = 10.1126/science.277.5333.1827 }}</ref><ref name="pmid9344864">{{cite journal | vauthors = Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T | title = Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase | journal = Biochemical and Biophysical Research Communications | volume = 239 | issue = 2 | pages = 527–33 | date = Oct 1997 | pmid = 9344864 | doi = 10.1006/bbrc.1997.7508 }}</ref>，在许多组织细胞中表达，如[[腎]]的{{le|近曲小管|Proximal tubule}}、[[皮肤]][[角质形成细胞]]、[[免疫细胞]]<ref name="pmid17259988">{{cite journal | vauthors = Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC | title = DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 | journal = Nature Immunology | volume = 8 | issue = 3 | pages = 285–93 | date = Mar 2007 | pmid = 17259988 | doi = 10.1038/ni1433 | url = http://www.biochem.wisc.edu/courses/biochem901/secure/materials/readings/08Sigmundsdottir_etal.pdf | access-date = 2020-04-30 | archive-date = 2020-03-19 | archive-url = https://web.archive.org/web/20200319150452/https://biochem.wisc.edu/courses/biochem901/secure/materials/readings/08Sigmundsdottir_etal.pdf | dead-url = yes }}</ref>、[[成骨细胞]]等<ref name="pmid20739402">{{cite journal | vauthors = Kogawa M, Findlay DM, Anderson PH, Ormsby R, Vincent C, Morris HA, Atkins GJ | title = Osteoclastic metabolism of 25(OH)-vitamin D3: a potential mechanism for optimization of bone resorption | journal = Endocrinology | volume = 151 | issue = 10 | pages = 4613–25 | date = Oct 2010 | pmid = 20739402 | doi = 10.1210/en.2010-0334 | doi-access = free }}</ref>，催化[[骨化二醇]][[羟基化]]生成[[骨化三醇]]（[[维生素D]]的活性形式）<ref name="pmid4404596">{{cite journal | vauthors = Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF | title = 25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties | url = https://archive.org/details/sim_journal-of-biological-chemistry_1972-12-10_247_23/page/7528 | journal = The Journal of Biological Chemistry | volume = 247 | issue = 23 | pages = 7528–32 | date = Dec 1972 | pmid = 4404596 | doi = 10.1016/S0021-9258(19)44557-2}}</ref>：

:骨化二醇 + 2 还原型 Adx + 2 H+ + O2  {{eqm}} 骨化三醇 + 2 氧化型 Adx + H2O

<gallery>
Image:Calcidiol2.svg|[[骨化二醇]]
Image:Calcitriol.svg |[[骨化三醇]]
</gallery>

{|
|{{enzyme
| Name = calcidiol 1-monooxygenase
| EC_number = 1.14.15.18
| CAS_number = 9081-36-1
| IUBMB_EC_number = 1/14/13/13
| GO_code = 0004498
| image =
| width =
| caption =
}}
|}

==参考文献==
{{reflist}}
==外部链接==
*[https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=ctx GeneReviews/NCBI/NIH/UW entry on Cerebrotendinous Xanthomatosis]{{Wayback|url=https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=ctx |date=20100321174316 }}
* {{MeshName|Cytochrome+P-450+CYP27A1}}
* {{UCSC gene info|CYP27A1}}

{{Cytochrome P450}}
{{双加氧酶类}}

[[Category:细胞色素P450|27]]

CYP27B1 - 版本历史

2026年1月3日 (六) 11:48 imported>曦城星月