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'''细胞色素P450 1A2（{{langx|en|Cytochrome P450 1A2}}）''' （缩写为'''CYP1A2'''），化学式为：C<sub>2689</sub>H<sub>4180</sub>O<sub>744</sub>N<sub>722</sub>S<sub>16</sub>Fe<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P05177@2-516@ |website=web.expasy.org |access-date=2026-01-03}}</ref>，是[[细胞色素P450]]混合功能氧化[[酶]]家族的一员，参与体内异生物质的[[代谢]]。<ref name="pmid15128046">{{cite journal | author = Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW | title = Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants | journal = Pharmacogenetics | volume = 14 | issue = 1 | pages = 1–18 |date=January 2004 | pmid = 15128046 | doi = 10.1097/00008571-200401000-00001| url = | issn = }}</ref>CYP1A2酶由人类''CYP1A2''[[基因]]编码。<ref name="pmid3681487">{{cite journal | author = Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ | title = Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15 | journal = J. Exp. Pathol. | volume = 3 | issue = 1 | pages = 1–17 | year = 1987 | pmid = 3681487 | doi = | url = | issn = }}</ref><br />
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==引用==<br />
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== 延伸閱讀 ==<br />
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* {{cite journal |author=Meijerman I, Beijnen J, Schellens J |title=Herb-drug interactions in oncology: focus on mechanisms of induction |journal=Oncologist |volume=11 |issue=7 |pages=742–52 |year= 2006|pmid=16880233 |doi=10.1634/theoncologist.11-7-742}}<br />
*{{cite journal | author=Smith G, Stubbins MJ, Harries LW, Wolf CR |title=Molecular genetics of the human cytochrome P450 monooxygenase superfamily. |journal=Xenobiotica |volume=28 |issue= 12 |pages= 1129–65 |year= 1999 |pmid= 9890157 |doi=10.1080/004982598238868 }}<br />
*{{cite journal | author=Landi MT, Sinha R, Lang NP, Kadlubar FF |title=Human cytochrome P4501A2. |journal=IARC Sci. Publ. |volume= |issue= 148 |pages= 173–95 |year= 1999 |pmid= 10493258 |doi= }}<br />
*{{cite journal | author=Ikeya K, Jaiswal AK, Owens RA |title=Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression. |journal=Mol. Endocrinol. |volume=3 |issue= 9 |pages= 1399–408 |year= 1990 |pmid= 2575218 |doi=10.1210/mend-3-9-1399 |display-authors=etal}}<br />
*{{cite journal | author=Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF |title=Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 20 |pages= 7696–700 |year= 1989 |pmid= 2813353 |doi=10.1073/pnas.86.20.7696 | pmc=298137 }}<br />
*{{cite journal | author=Quattrochi LC, Okino ST, Pendurthi UR, Tukey RH |title=Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. |journal=DNA |volume=4 |issue= 5 |pages= 395–400 |year= 1986 |pmid= 3000715 |doi=10.1089/dna.1985.4.395 }}<br />
*{{cite journal | author=Quattrochi LC, Pendurthi UR, Okino ST |title=Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 18 |pages= 6731–5 |year= 1986 |pmid= 3462722 |doi=10.1073/pnas.83.18.6731 | pmc=386583 |display-authors=etal}}<br />
*{{cite journal | author=Wrighton SA, Campanile C, Thomas PE |title=Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat. |journal=Mol. Pharmacol. |volume=29 |issue= 4 |pages= 405–10 |year= 1986 |pmid= 3517618 |doi= |display-authors=etal}}<br />
*{{cite journal | author=Jaiswal AK, Nebert DW, Gonzalez FJ |title=Human P3(450): cDNA and complete amino acid sequence. | url=https://archive.org/details/sim_nucleic-acids-research_1986-08-26_14_16/page/6772 |journal=Nucleic Acids Res. |volume=14 |issue= 16 |pages= 6773–4 |year= 1986 |pmid= 3755823 |doi=10.1093/nar/14.16.6773 | pmc=311685 }}<br />
*{{cite journal | author=Eugster HP, Probst M, Würgler FE, Sengstag C |title=Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae. |journal=Drug Metab. Dispos. |volume=21 |issue= 1 |pages= 43–9 |year= 1993 |pmid= 8095225 |doi= }}<br />
*{{cite journal | author=Schweikl H, Taylor JA, Kitareewan S |title=Expression of CYP1A1 and CYP1A2 genes in human liver. |journal=Pharmacogenetics |volume=3 |issue= 5 |pages= 239–49 |year= 1994 |pmid= 8287062 |doi=10.1097/00008571-199310000-00003 |display-authors=etal}}<br />
*{{cite journal | author=Yamazaki H, Inoue K, Mimura M |title=7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes. | url=https://archive.org/details/sim_biochemical-pharmacology_1996-02-09_51_3/page/312 |journal=Biochem. Pharmacol. |volume=51 |issue= 3 |pages= 313–9 |year= 1996 |pmid= 8573198 |doi=10.1016/0006-2952(95)02178-7 |display-authors=etal}}<br />
*{{cite journal | author=Hakkola J, Raunio H, Purkunen R |title=Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. | url=https://archive.org/details/sim_biochemical-pharmacology_1996-07-26_52_2/page/378 |journal=Biochem. Pharmacol. |volume=52 |issue= 2 |pages= 379–83 |year= 1996 |pmid= 8694864 |doi=10.1016/0006-2952(96)00216-X |display-authors=etal}}<br />
*{{cite journal | author=Guengerich FP, Johnson WW |title=Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems. |journal=Biochemistry |volume=36 |issue= 48 |pages= 14741–50 |year= 1998 |pmid= 9398194 |doi= 10.1021/bi9719399 }}<br />
*{{cite journal | author=Wacke R, Kirchner A, Prall F |title=Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis. |journal=Pancreas |volume=16 |issue= 4 |pages= 521–8 |year= 1998 |pmid= 9598815 |doi=10.1097/00006676-199805000-00011 |display-authors=etal}}<br />
*{{cite journal | author=Macé K, Bowman ED, Vautravers P |title=Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues. |journal=Eur. J. Cancer |volume=34 |issue= 6 |pages= 914–20 |year= 1998 |pmid= 9797707 |doi=10.1016/S0959-8049(98)00034-3 |display-authors=etal}}<br />
*{{cite journal | author=Huang JD, Guo WC, Lai MD |title=Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese. |journal=Drug Metab. Dispos. |volume=27 |issue= 1 |pages= 98–101 |year= 1999 |pmid= 9884316 |doi= |display-authors=etal}}<br />
*{{cite journal | author=Tatemichi M, Nomura S, Ogura T |title=Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia. | url=https://archive.org/details/sim_cancer-research_1999-08-15_59_16/page/3892 |journal=Cancer Res. |volume=59 |issue= 16 |pages= 3893–8 |year= 1999 |pmid= 10463577 |doi= |display-authors=etal}}<br />
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[[Category:细胞色素P450|1]]</div>
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