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'''CXCL11'''（{{langx|en|Chemokine (C-X-C motif) ligand 11}}）化学式为：C<sub>368</sub>H<sub>618</sub>O<sub>99</sub>N<sub>106</sub>S<sub>6</sub><ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?O14625@22-94@ |website=web.expasy.org |access-date=2026-02-10}}</ref>，是一小分子的[[细胞因子]]属于CXC[[趋化因子]]家族<ref name=cole>Cole et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 187: 2009-2021, 1998.</ref>，又被称作“干扰素诱导的T细胞a趋化因子”（Interferon-inducible T-cell alpha chemoattractant (I-TAC)<ref name=cole/>。<br />
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== 表达 ==<br />
在[[白细胞]]，[[胰腺]]和[[肝脏]]中表达水平高，在[[胸腺]]，[[脾]]和[[肺]]有中等水平的表达，在[[小肠]]，[[胎盘]]和[[前列腺]]中表达水平低<ref name=cole/>。[[干扰素伽玛]]和干扰素－b可以在单核细胞<ref name=cole/>，支气管上皮细胞<ref name=sau>Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999) The T cell-specific CXC chemokines IP-10, MIG, and I-TAC are expressed by activated human bronchial epithelial cells J. Immunol. 162,3549-3558</ref>，[[中性粒细胞]]<ref name=gas>Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M., Liao, F., Farber, J., Cassatella, M. A. (1999) Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils J. Immunol. 162,4928-4937.</ref>，角质形成细胞<ref name=ten>Tensen, C. P., Flier, J., Van Der Raaij-Helmer, E. M., Sampat-Sardjoepersad, S., Van Der Schors, R. C., Leurs, R., Scheper, R. J., Boorsma, D. M., Willemze, R. (1999) Human IP-9: a keratinocyte-derived high-affinity CXC-chemokine ligand for the IP-10/MIG receptor (CXCR3) J. Invest. Dermatol. 112,716-72.</ref>，和内皮细胞诱导CXCL11的表达。<br />
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== 受体 ==<br />
CXCL11结合趋化因子受体[[CXCR3]]而起其细胞趋化作用<ref name=cole/><ref>Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.</ref><ref>Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.</ref>。CXCL11也可以结合到趋化因子受体[[CCR3]]上而阻止CCR3配体的结合<ref name=loe>Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 Feb 2;276(5):2986-91</ref>。<br />
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== 功能 ==<br />
CXCL11对活化的T细胞，中性粒细胞和单核细胞有细胞趋化作用<ref name=cole/>。<br />
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== 参见 ==<br />
*[[趋化因子]]<br />
*[[CXCR3]]<br />
*[[CXCL9]]<br />
*[[CXCL10]]<br />
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== 参考文献 ==<br />
{{Reflist}}<br />
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== 外部链接 ==<br />
*[http://content.nejm.org/cgi/content/extract/354/6/610 Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.]{{Wayback|url=http://content.nejm.org/cgi/content/extract/354/6/610 |date=20070110225703 }}<br />
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{{细胞因子}}<br />
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[[Category:细胞因子]]<br />
[[Category:免疫学]]</div>imported>曦城星月