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{{infobox_gene}}
'''CXCL10'''（{{langx|en|C-X-C motif chemokine 10}}）是一小分子的[[细胞因子]]属于CXC[[趋化因子]]家族<ref>Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.</ref>，又被称作“干扰素伽玛诱导的10千道尔顿蛋白”（10 kDa interferon-gamma-induced protein，IP-10）<ref>Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.</ref>化学式为：C375H652O108N114S5<ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P02778@22-98@ |website=web.expasy.org |access-date=2026-02-10}}</ref>。[[干扰素伽玛]]可以在多种细胞（如[[巨噬细胞]]<ref name=nor>Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.</ref>，[[单核细胞]]<ref name=nor/>，[[内皮细胞]]<ref name=ang>Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.</ref>和[[成纤维细胞]]）中诱导CXCL10的表达。CXCL10的功能包括对[[T细胞]]和单核细胞的细胞趋化作用<ref name=chemo>Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.</ref><ref name=fun>Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.</ref>，促进T细胞黏附于内皮细胞<ref name=ang/>，抗[[肿瘤]]<ref>Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65</ref>，及[[血管新生]]<ref name=ang/>。人类的CXCL10基因与[[CXCL9]]，[[CXCL11]]的基因相邻聚集在第四染色体上。CXCL10, CXCL9和CXCL11结合[[趋化因子受体]][[CXCR3]]而起其细胞趋化作用<ref name=chemo/><ref name=fun/>。

== 参见 ==
* [[趋化因子]]
* [[CXCR3]]
* [[CXCL9]]
* [[CXCL11]]

== 参考文献 ==
{{Reflist}}

== 外部链接 ==
* [http://content.nejm.org/cgi/content/extract/354/6/610 Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.]{{Wayback|url=http://content.nejm.org/cgi/content/extract/354/6/610 |date=20070110225703 }}

{{细胞因子}}

[[Category:细胞因子]]
[[Category:免疫学]]

CXCL10 - 版本历史

imported>曦城星月 来自 2026年2月10日 (二) 10:49

imported>曦城星月来自 2026年2月10日 (二) 10:49