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<p></p> <p><b>新页面</b></p><div>{{PBB|geneid=2919}}<br /> &#039;&#039;&#039;CXCL1&#039;&#039;&#039;（{{langx|en|Chemokine (C-X-C motif) ligand 1}}）是一小分子的[[细胞因子]]属于CXC[[趋化因子]]家族&lt;ref name=mos&gt;Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.&lt;/ref&gt;。又被称作&#039;&#039;&#039;生长调节致癌基因α&#039;&#039;&#039; (Growth-regulated oncogene alpha, GROα)&lt;ref name=mos/&gt;&lt;ref name=&quot;#1&quot;&gt;Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.&lt;/ref&gt;&lt;ref name=&quot;#2&quot;&gt;Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198&lt;/ref&gt;化学式为：C&lt;sub&gt;337&lt;/sub&gt;H&lt;sub&gt;572&lt;/sub&gt;O&lt;sub&gt;103&lt;/sub&gt;N&lt;sub&gt;102&lt;/sub&gt;S&lt;sub&gt;5&lt;/sub&gt;&lt;ref&gt;{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P09341@35-107@ |website=web.expasy.org |access-date=2026-02-10}}&lt;/ref&gt;。 趋化因子CXCL1是由[[巨噬细胞]]，[[中性粒细胞]]和[[上皮细胞]]表达的&lt;ref&gt;Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.&lt;/ref&gt;&lt;ref&gt;Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.&lt;/ref&gt;。趋化因子CXCL1对中性粒细胞有细胞趋化作用&lt;ref name=mos/&gt;。CXCL1结合到趋化因子受体[[CXCR2]]上而起细胞趋化作用&lt;ref name=&quot;#3&quot;&gt;Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244&lt;/ref&gt;。人类的CXCL1与许多CXC类的趋化因子基因相邻聚集在第四染色体上&lt;ref name=ric&gt;Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.&lt;/ref&gt;。CXCL1的主要作用包括新血管形成、炎症反应、伤口愈合&lt;ref name=&quot;#3&quot;/&gt;和肿瘤形成&lt;ref name=&quot;#1&quot;/&gt;&lt;ref name=&quot;#2&quot;/&gt;。<br /> <br /> == 参见 ==<br /> *[[CXCR2]]<br /> *[[趋化因子]]<br /> <br /> == 参考文献 ==<br /> {{Reflist}}<br /> <br /> {{细胞因子}}<br /> <br /> [[Category:细胞因子]]</div>

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