https://arolstar52-zhtest.hf.space/index.php?action=history&feed=atom&title=CTLA-4 2026-07-17T07:52:50Z 在这个wiki上该页的修订历史 MediaWiki 1.43.9 https://arolstar52-zhtest.hf.space/index.php?title=CTLA-4&diff=3794168&oldid=prev 2025-10-17T22:09:58Z

<p>Add 2 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (<a href="/index.php?title=User:GreenC_bot&amp;action=edit&amp;redlink=1" class="new" title="User:GreenC bot（页面不存在）">GreenC bot</a></p> <p><b>新页面</b></p><div>{{Infobox gene}} <br /> &#039;&#039;&#039;CTLA4&#039;&#039;&#039;又稱&#039;&#039;&#039;CTLA-4&#039;&#039;&#039;（細胞毒性T淋巴細胞相關抗原4，cytotoxic T-lymphocyte-associated protein 4）或&#039;&#039;&#039;CD152&#039;&#039;&#039;（[[分化群]]152），是一种[[受体 (生物化学)|蛋白质受体]]&lt;ref name=&quot;:0&quot;&gt;{{Cite journal|title=De-novo and acquired resistance to immune checkpoint targeting|date=December 2017|journal=The Lancet. Oncology|issue=12|doi=10.1016/s1470-2045(17)30607-1|volume=18|pages=e731–e741|pmid=29208439}}&lt;/ref&gt;。CTLA-4蛋白由小鼠的Ctla4&lt;ref name=&quot;pmid3496540&quot;&gt;{{Cite journal|title=A new member of the immunoglobulin superfamily--CTLA-4|url=https://archive.org/details/sim_nature-uk_1987-07-16_328_6127/page/n95|journal=Nature|issue=6127|doi=10.1038/328267a0|year=1987|volume=328|pages=267–70|bibcode=1987Natur.328..267B|pmid=3496540}}&lt;/ref&gt;和人类的CTLA4基因编码&lt;ref name=&quot;pmid3220103&quot;&gt;{{Cite journal|title=Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains|date=December 1988|journal=European Journal of Immunology|issue=12|doi=10.1002/eji.1830181206|volume=18|pages=1901–5|pmid=3220103}}&lt;/ref&gt;。CTLA-4于1991年首次被發現&lt;ref name=&quot;Waterhouse_1995&quot;&gt;{{Cite journal|title=Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4|url=https://archive.org/details/sim_science_1995-11-10_270_5238/page/984|date=November 1995|journal=Science|issue=5238|doi=10.1126/science.270.5238.985|volume=270|pages=985–8|bibcode=1995Sci...270..985W|jstor=2888113|pmid=7481803}}&lt;/ref&gt;。<br /> <br /> ==参考文献==<br /> {{reflist}}<br /> <br /> [[Category:T细胞]]<br /> [[Category:分化群]]<br /> [[Category:位於2號人類染色體的基因]]</div>

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