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[[File:COS-7 Cells - 40X Magnification - Confocal Microscopy.jpg|thumb|COS-7細胞]]

'''COS-7''' (亦稱'''ATCC CRL-1651'''、'''CV-1 in Origin Simian-7''') 是在[[1980年代]]初期發現的[[非洲]][[綠猴]][[腎]][[細胞系]]，最初是經帶有編碼[[野生型]]T[[抗原]]的起始失活[[突變]]的[[SV40|猿猴空泡病毒40]][[轉染]]而建立<ref name=a>{{cite journal |last1=Gluzman |first1=Y |title=SV40-transformed simian cells support the replication of early SV40 mutants. |journal=Cell |date=1981-01 |volume=23 |issue=1 |pages=175-82 |doi=10.1016/0092-8674(81)90282-8 |pmid=6260373 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/6260373/ |accessdate=2019-12-08}}</ref><ref name=b>{{cite journal |last1=Mellon |first1=P |last2=Parker |first2=V |last3=Gluzman |first3=Y |last4=Maniatis |first4=T |title=Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. |journal=Cell |date=1981-12 |volume=27 |issue=2 Pt 1 |pages=279-88 |doi=10.1016/0092-8674(81)90411-6 |pmid=6277501 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/6277501/ |accessdate=2019-12-08}}</ref>，具有[[成纖維細胞]]樣和[[病毒]]敏感性的獨特特徵<ref name=a/><ref name=b/>。穩定的[[細胞系]]是轉運體相互作用[[研究]]及體外評價[[藥物]]候選物的理想[[模型]]，其中常用的其中一個[[宿主]]細胞系就是COS-7細胞。COS-7細胞也會應用在[[轉錄|細胞基因轉錄]]的研究及DNA[[質體]][[轉染]]實驗<ref>{{cite journal |last1=Smale |first1=ST |last2=Baltimore |first2=D |title=The "initiator" as a transcription control element. |journal=Cell |date=1989-04-07 |volume=57 |issue=1 |pages=103-13 |doi=10.1016/0092-8674(89)90176-1 |pmid=2467742 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/2467742/ |accessdate=2019-12-08}}</ref>，從而分析[[類固醇]]生成[[基因]]<ref>{{cite journal |last1=Kawamoto |first1=T |last2=Mitsuuchi |first2=Y |last3=Toda |first3=K |last4=Yokoyama |first4=Y |last5=Miyahara |first5=K |last6=Miura |first6=S |last7=Ohnishi |first7=T |last8=Ichikawa |first8=Y |last9=Nakao |first9=K |last10=Imura |first10=H |title=Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans. |journal=Proceedings of the National Academy of Sciences of the United States of America |date=1992-02-15 |volume=89 |issue=4 |pages=1458-62 |doi=10.1073/pnas.89.4.1458 |pmid=1741400 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/1741400/ |accessdate=2019-12-08}}</ref>、類固醇[[受體]]的功能<ref>{{cite journal |last1=Simental |first1=JA |last2=Sar |first2=M |last3=Lane |first3=MV |last4=French |first4=FS |last5=Wilson |first5=EM |title=Transcriptional activation and nuclear targeting signals of the human androgen receptor. |journal=The Journal of biological chemistry |date=1991-01-05 |volume=266 |issue=1 |pages=510-8 |pmid=1985913 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/1985913/ |accessdate=2019-12-08}}</ref>及類固醇對功能[[分子]]的作用<ref>{{cite journal |last1=Topor |first1=LS |last2=Asai |first2=M |last3=Dunn |first3=J |last4=Majzoub |first4=JA |title=Cortisol stimulates secretion of dehydroepiandrosterone in human adrenocortical cells through inhibition of 3betaHSD2. |journal=The Journal of clinical endocrinology and metabolism |date=2011-01 |volume=96 |issue=1 |pages=E31-9 |doi=10.1210/jc.2010-0692 |pmid=20943790 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038480/ |accessdate=2019-12-08}}</ref>。COS-7是源自非類固醇生成[[器官]]的非類固醇生成細胞<ref>{{cite journal |last1=West |first1=LA |last2=Horvat |first2=RD |last3=Roess |first3=DA |last4=Barisas |first4=BG |last5=Juengel |first5=JL |last6=Niswender |first6=GD |title=Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane. |journal=Endocrinology |date=2001-01 |volume=142 |issue=1 |pages=502-5 |doi=10.1210/endo.142.1.8052 |pmid=11145616 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/11145616/ |accessdate=2019-12-08}}</ref><ref>{{cite journal |last1=Rasheeda |first1=MK |last2=Kagawa |first2=H |last3=Kirubagaran |first3=R |last4=Dutta-Gupta |first4=A |last5=Senthilkumaran |first5=B |title=Cloning, expression and enzyme activity analysis of testicular 11beta-hydroxysteroid dehydrogenase during seasonal cycle and after hCG induction in air-breathing catfish Clarias gariepinus. |journal=The Journal of steroid biochemistry and molecular biology |date=2010-05 |volume=120 |issue=1 |pages=1-10 |doi=10.1016/j.jsbmb.2010.02.014 |pmid=20219674 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/20219674/ |accessdate=2019-12-08}}</ref>，然而有研究表明COS-7細胞可將3H-[[睪酮]][[代謝]]為3H-[[雄烯二酮]]<ref>{{cite journal |last1=Nozaki |first1=M |last2=Haraguchi |first2=S |last3=Miyazaki |first3=T |last4=Shigeta |first4=D |last5=Kano |first5=N |last6=Lei |first6=XF |last7=Kim-Kaneyama |first7=JR |last8=Minakata |first8=H |last9=Miyazaki |first9=A |last10=Tsutsui |first10=K |title=Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells. |journal=Scientific reports |date=2018-02-01 |volume=8 |issue=1 |pages=2167 |doi=10.1038/s41598-018-20226-2 |pmid=29391479 |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794755/#!po=71.7742 |accessdate=2019-12-08}}</ref>。

== 參考資料 ==
{{Reflist|2}}

== 外部連結 ==
*[https://web.expasy.org/cellosaurus/CVCL_0224 Cellosaurus entry for COS-7]{{Wayback|url=https://web.expasy.org/cellosaurus/CVCL_0224 |date=20191208131155 }}

[[Category:細胞系]]

COS-7 - 版本历史

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imported>Cewbot：bot: 清理跨語言連結細胞系成為內部連結:編輯摘要的red link經繁簡轉換後存在