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CDX1 - 版本历史
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同源框蛋白CDX-1（'''Homeobox protein CDX-1'''）化学式为：C<sub>1273</sub>H<sub>1946</sub>O<sub>364</sub>N<sub>350</sub>S<sub>5</sub><ref>{{Cite web |title=Expasy - ProtParam |url=https://web.expasy.org/cgi-bin/protparam/protparam_bis.cgi?P47902@1-265@ |website=web.expasy.org |access-date=2026-02-11}}</ref>，是一种由[[基因]]''CDX1''编码的[[蛋白质]]。<ref name="pmid8530027">{{cite journal | author = Bonner CA, Loftus SK, Wasmuth JJ | title = Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene | journal = Genomics | volume = 28 | issue = 2 | pages = 206–11 |date=Feb 1996 | pmid = 8530027 | pmc = | doi = 10.1006/geno.1995.1132 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDX1 caudal type homeobox transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1044| accessdate = }}</ref><br />
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该基因是尾型[[同源框]][[转录因子]]基因家族的一员。其编码的DNA结合蛋白用以调控肠道特异性基因的表达和肠上皮细胞的分化。已知它能诱导肠道[[碱性磷酸酶]]的表达，并抑制β-连环素和T细胞因子的转录活性<ref name="entrez" />。<br />
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==参考文献==<br />
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==延伸阅读==<br />
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| citations = <br />
*{{cite journal | author= |title=Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group |journal=Nat. Genet. |volume=12 |issue= 2 |pages= 130–6 |year= 1996 |pmid= 8563749 |doi= 10.1038/ng0296-130 | last1= Dixon | first1= Jill | last2= Edwards | first2= Sara J. | last3= Gladwin | first3= Amanda J. | last4= Dixon | first4= Michael J. | last5= Loftus | first5= Stacie K. | last6= Bonner | first6= Cynthia A. | last7= Koprivnikar | first7= Kathryn | last8= Wasmuth | first8= John J. }}<br />
*{{cite journal | author=Mallo GV, Rechreche H, Frigerio JM, ''et al.'' |title=Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis |journal=Int. J. Cancer |volume=74 |issue= 1 |pages= 35–44 |year= 1997 |pmid= 9036867 |doi=10.1002/(SICI)1097-0215(19970220)74:1<35::AID-IJC7>3.0.CO;2-1 }}<br />
*{{cite journal | author=Mizoshita T, Inada K, Tsukamoto T, ''et al.'' |title=Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach |journal=Gastric Cancer |volume=4 |issue= 4 |pages= 185–91 |year= 2002 |pmid= 11846061 |doi=10.1007/PL00011741 }}<br />
*{{cite journal | author=Suh ER, Ha CS, Rankin EB, ''et al.'' |title=DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines | url=https://archive.org/details/sim_journal-of-biological-chemistry_2002-09-27_277_39/page/35794 |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 35795–800 |year= 2002 |pmid= 12124393 |doi= 10.1074/jbc.M205567200 }}<br />
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}<br />
*{{cite journal | author=Domon-Dell C, Schneider A, Moucadel V, ''et al.'' |title=Cdx1 homeobox gene during human colon cancer progression |journal=Oncogene |volume=22 |issue= 39 |pages= 7913–21 |year= 2003 |pmid= 12970739 |doi= 10.1038/sj.onc.1206756 }}<br />
*{{cite journal | author=Wong NA, Britton MP, Choi GS, ''et al.'' |title=Loss of CDX1 expression in colorectal carcinoma: Promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 2 |pages= 574–9 |year= 2004 |pmid= 14704280 |doi= 10.1073/pnas.0307190101 | pmc=327189 }}<br />
*{{cite journal | author=Rankin EB, Xu W, Silberg DG, Suh E |title=Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=286 |issue= 5 |pages= G872–80 |year= 2004 |pmid= 14715525 |doi= 10.1152/ajpgi.00326.2003 }}<br />
*{{cite journal | author=Béland M, Pilon N, Houle M, ''et al.'' |title=Cdx1 Autoregulation Is Governed by a Novel Cdx1-LEF1 Transcription Complex | url=https://archive.org/details/sim_molecular-and-cellular-biology_2004-06_24_11/page/5028 |journal=Mol. Cell. Biol. |volume=24 |issue= 11 |pages= 5028–38 |year= 2004 |pmid= 15143193 |doi= 10.1128/MCB.24.11.5028-5038.2004 | pmc=416402 }}<br />
*{{cite journal | author=Guo RJ, Huang E, Ezaki T, ''et al.'' |title=Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity | url=https://archive.org/details/sim_journal-of-biological-chemistry_2004-08-27_279_35/page/36865 |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36865–75 |year= 2004 |pmid= 15215241 |doi= 10.1074/jbc.M405213200 }}<br />
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}<br />
*{{cite journal | author=Alkhoury F, Malo MS, Mozumder M, ''et al.'' |title=Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2 |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=289 |issue= 2 |pages= G285–90 |year= 2005 |pmid= 15774940 |doi= 10.1152/ajpgi.00037.2005 }}<br />
*{{cite journal | author=Wong NA, Wilding J, Bartlett S, ''et al.'' |title=CDX1 is an important molecular mediator of Barrett's metaplasia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 21 |pages= 7565–70 |year= 2005 |pmid= 15894614 |doi= 10.1073/pnas.0502031102 | pmc=1140438 }}<br />
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== 外部链接 ==<br />
* {{MeshName|CDX1+protein,+human}}<br />
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{{gene-5-stub}}<br />
{{NLM content}}<br />
{{Transcription factors|g3}}<br />
[[Category:转录因子]]<br />
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imported>曦城星月