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{{Infobox_gene}}
'''CD43（'''[[白血球分化抗原|白细胞分化抗原]]43'''）'''又名'''白细胞唾液酸糖蛋白'''（{{lang|en|Leukosialin}}）或'''唾液酸蛋白'''（{{lang|en|sialophorin}}），是一种跨膜表面蛋白，在人体中由''SPN''（唾液蛋白）基因编码<ref>{{Cite web|url=http://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6693|title=SPN sialophorin [Homo sapiens (human)] - Gene - NCBI|accessdate=2018-07-15|work=www.ncbi.nlm.nih.gov|archive-date=2019-02-15|archive-url=https://web.archive.org/web/20190215172748/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6693|dead-url=no}}</ref><ref name=":0">{{Cite journal|title=Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16|url=https://www.ncbi.nlm.nih.gov/pubmed/2521952|last=Pallant|first=A.|last2=Eskenazi|first2=A.|date=1989-2|journal=Proceedings of the National Academy of Sciences of the United States of America|issue=4|volume=86|pages=1328–1332|issn=0027-8424|pmc=286683|pmid=2521952|last3=Mattei|first3=M. G.|last4=Fournier|first4=R. E.|last5=Carlsson|first5=S. R.|last6=Fukuda|first6=M.|last7=Frelinger|first7=J. G.|access-date=2018-07-15|archive-date=2018-08-20|archive-url=https://web.archive.org/web/20180820193301/https://www.ncbi.nlm.nih.gov/pubmed/2521952|dead-url=no}}</ref><ref>{{Cite journal|title=Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/2784859|last=Shelley|first=C. S.|last2=Remold-O'Donnell|first2=E.|date=1989-4|journal=Proceedings of the National Academy of Sciences of the United States of America|issue=8|volume=86|pages=2819–2823|issn=0027-8424|pmc=287010|pmid=2784859|last3=Davis|first3=A. E.|last4=Bruns|first4=G. A.|last5=Rosen|first5=F. S.|last6=Carroll|first6=M. C.|last7=Whitehead|first7=A. S.|access-date=2018-07-15|archive-date=2018-08-20|archive-url=https://web.archive.org/web/20180820193237/https://www.ncbi.nlm.nih.gov/pubmed/2784859|dead-url=no}}</ref>。

== 功能 ==
唾液蛋白（leukosialin）是人类T淋巴细胞，单核细胞，粒细胞和一些B淋巴细胞表面的主要唾液酸糖蛋白，它们似乎对免疫功能很重要，可能是参与T细胞活化的生理性配体 - 受体复合物的一部分<ref name=":0" />。

== 临床意义 ==
CD43分子中的缺陷与[[Wiskott-Aldrich综合征]]的发病有关<ref>{{Cite journal|title=Sialophorin (CD43) and the Wiskott-Aldrich syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/2223062|last=Remold-O'Donnell|first=E.|last2=Rosen|first2=F. S.|date=1990|journal=Immunodeficiency Reviews|issue=2|volume=2|pages=151–174|issn=0893-5300|pmid=2223062|access-date=2018-07-15|archive-date=2018-07-16|archive-url=https://web.archive.org/web/20180716023840/https://www.ncbi.nlm.nih.gov/pubmed/2223062|dead-url=no}}</ref>。也在大约25％的肠道MALT瘤中出现，通过免疫组织化学技术，可以在健康淋巴结和扁桃体的皮质T细胞中证实CD43的存在。CD43在一系列淋巴和骨髓肿瘤中也是阳性的。虽然它于超过90％的T细胞淋巴瘤中存在，但它在诊断这些病症方面通常不如CD3抗原有效。然而，它可以作为一系列抗原的一部分用于诊断B细胞淋巴母细胞淋巴瘤，因为在这种情况下的恶性细胞通常CD43是阳性的，并且可能难以用其他抗体染色。因为它会污染粒细胞及其前体细胞，它也是骨髓瘤的有效标记物<ref>{{Cite book|url=https://www.worldcat.org/oclc/51439459|last=1945-2011.|first=Leong, Anthony S.-Y. (Anthony Siew-Yin),|last2=W.-M.|first2=Leong, F. Joel|date=2003|publisher=Greenwich Medical Media|isbn=9781841101002|edition=2nd ed|location=London|chapter=Manual of diagnostic antibodies for immunohistology|oclc=51439459|title=|access-date=2018-07-15|archive-date=2019-09-24|archive-url=https://web.archive.org/web/20190924183516/https://www.worldcat.org/title/manual-of-diagnostic-antibodies-for-immunohistology/oclc/51439459|dead-url=no}}</ref>。

== 相互作用 ==
CD43已被证实与埃兹蛋白''Ezrin''<ref>{{Cite journal|title=CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts|url=https://www.ncbi.nlm.nih.gov/pubmed/9616160|last=Serrador|first=J. M.|last2=Nieto|first2=M.|date=1998-06-15|journal=Blood|issue=12|volume=91|pages=4632–4644|issn=0006-4971|pmid=9616160|last3=Alonso-Lebrero|first3=J. L.|last4=del Pozo|first4=M. A.|last5=Calvo|first5=J.|last6=Furthmayr|first6=H.|last7=Schwartz-Albiez|first7=R.|last8=Lozano|first8=F.|last9=González-Amaro|first9=R.|access-date=2018-07-15|archive-date=2018-07-15|archive-url=https://web.archive.org/web/20180715210826/https://www.ncbi.nlm.nih.gov/pubmed/9616160|dead-url=no}}</ref>和膜突蛋白''Moesin''<ref>{{Cite journal|title=Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2|url=https://www.ncbi.nlm.nih.gov/pubmed/9472040|last=Yonemura|first=S.|last2=Hirao|first2=M.|date=1998-02-23|journal=The Journal of Cell Biology|issue=4|volume=140|pages=885–895|issn=0021-9525|pmc=2141743|pmid=9472040|last3=Doi|first3=Y.|last4=Takahashi|first4=N.|last5=Kondo|first5=T.|last6=Tsukita|first6=S.|last7=Tsukita|first7=S.|access-date=2018-07-15|archive-date=2018-07-16|archive-url=https://web.archive.org/web/20180716023846/https://www.ncbi.nlm.nih.gov/pubmed/9472040|dead-url=no}}</ref>具有相互作用。

==参考文献==
<references />
== 外部链接 ==
* {{MeshName|CD43+antigen}}
* {{UCSC gene info|SPN}}

{{分化簇}}
{{糖蛋白类}}

[[Category:分化群]]
[[Category:膜蛋白]]
[[Category:黏液素]]

CD43 - 版本历史

imported>JimGrassroot：​使用HotCat已移除Category:粘蛋白

imported>JimGrassroot：使用HotCat已移除Category:粘蛋白