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{{Infobox_gene}}
'''整联蛋白β-1'''（{{langx|en|Integrin beta-1}}），也被称为 '''CD29''' 是一个由人类[[基因]] ''ITGB1'' 编码的[[蛋白质]]<ref name="pmid2524991">{{Cite journal|title=Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2|date=Jan 1989|journal=Annals of Human Genetics|issue=Pt 1|doi=10.1111/j.1469-1809.1989.tb01118.x|volume=53|pages=15–22|pmid=2524991}}</ref>。CD29是[[整合素]]极晚期抗原受体的一个亚基。它与α-3亚基形成整合素α3β1，作为[[神经生长因子1]]和[[络丝蛋白]]的受体。在[[心肌]]和[[骨骼肌]]种，整联蛋白β-1会选择性表达为β-1D蛋白质异形体。

== 相互作用 ==
CD29已经显示出与下列[[蛋白質交互作用]]：
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* [[ACTN1]];<ref>{{cite journal | vauthors = Otey CA, Pavalko FM, Burridge K | title = An interaction between alpha-actinin and the beta 1 integrin subunit in vitro | url = https://archive.org/details/sim_journal-of-cell-biology_1990-08_111_2/page/721 | journal = The Journal of Cell Biology | volume = 111 | issue = 2 | pages = 721–9 | date = Aug 1990 | pmid = 2116421 | doi=10.1083/jcb.111.2.721 | pmc=2116186}}</ref><ref>{{cite journal | vauthors = Otey CA, Vasquez GB, Burridge K, Erickson BW | title = Mapping of the alpha-actinin binding site within the beta 1 integrin cytoplasmic domain | url = https://archive.org/details/sim_journal-of-biological-chemistry_1993-10-05_268_28/page/21192 | journal = The Journal of Biological Chemistry | volume = 268 | issue = 28 | pages = 21193–7 | date = Oct 1993 | pmid = 7691808 }}</ref>
* [[CD46]],<ref name=pmid10741407>{{cite journal | vauthors = Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E | title = CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans | journal = European Journal of Immunology | volume = 30 | issue = 3 | pages = 900–7 | date = Mar 2000 | pmid = 10741407 | doi = 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X }}</ref>
* [[CD9]],<ref name=pmid8630057>{{cite journal | vauthors = Radford KJ, Thorne RF, Hersey P | title = CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma | journal = Biochemical and Biophysical Research Communications | volume = 222 | issue = 1 | pages = 13–8 | date = May 1996 | pmid = 8630057 | doi = 10.1006/bbrc.1996.0690 }}</ref><ref name=pmid12175627>{{cite journal | vauthors = Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M | title = Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration | journal = Journal of Hepatology | volume = 37 | issue = 3 | pages = 322–30 | date = Sep 2002 | pmid = 12175627 | doi = 10.1016/S0168-8278(02)00175-7 }}</ref>
* [[FHL2]],<ref name=pmid10906324>{{cite journal | vauthors = Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M | title = The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes | url = https://archive.org/details/sim_journal-of-biological-chemistry_2000-10-27_275_43/page/33668 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 43 | pages = 33669–78 | date = Oct 2000 | pmid = 10906324 | doi = 10.1074/jbc.M002519200 }}</ref>
* [[Filamin]],<ref name= "pmid11807098">{{cite journal | vauthors = van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A | title = Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits | url = https://archive.org/details/sim_journal-of-cell-biology_2002-01-21_156_2/page/n163 | journal = The Journal of Cell Biology | volume = 156 | issue = 2 | pages = 361–76 | date = Jan 2002 | pmid = 11807098 | pmc = 2199218 | doi = 10.1083/jcb.200103037 }}</ref><ref name=pmid9722563>{{cite journal | vauthors = Loo DT, Kanner SB, Aruffo A | title = Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction | url = https://archive.org/details/sim_journal-of-biological-chemistry_1998-09-04_273_36/page/23304 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 36 | pages = 23304–12 | date = Sep 1998 | pmid = 9722563 | doi = 10.1074/jbc.273.36.23304 }}</ref>
* [[FLNB]],<ref name = "pmid11807098"/>
* [[CD81]],<ref name=pmid12175627/><ref name=pmid10229664>{{cite journal | vauthors = Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E | title = Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions | journal = The Biochemical Journal | volume = 340 | issue = Pt 1 | pages = 103–11 | date = May 1999 | pmid = 10229664 | pmc = 1220227 | doi = 10.1042/0264-6021:3400103 }}</ref>
* [[GNB2L1]],<ref name=pmid12435334/><ref name=pmid9442085>{{cite journal | vauthors = Liliental J, Chang DD | title = Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit | url = https://archive.org/details/sim_journal-of-biological-chemistry_1998-01-23_273_4/page/2378 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 2379–83 | date = Jan 1998 | pmid = 9442085 | doi = 10.1074/jbc.273.4.2379 }}</ref>
* [[ITGB1BP1]],<ref name=pmid9281591>{{cite journal | vauthors = Chang DD, Wong C, Smith H, Liu J | title = ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin | url = https://archive.org/details/sim_journal-of-cell-biology_1997-09-08_138_5/page/1148 | journal = The Journal of Cell Biology | volume = 138 | issue = 5 | pages = 1149–57 | date = Sep 1997 | pmid = 9281591 | pmc = 2136751 | doi = 10.1083/jcb.138.5.1149 }}</ref><ref name=pmid11741908>{{cite journal | vauthors = Chang DD, Hoang BQ, Liu J, Springer TA | title = Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin | url = https://archive.org/details/sim_journal-of-biological-chemistry_2002-03-08_277_10/page/8140 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8140–5 | date = Mar 2002 | pmid = 11741908 | doi = 10.1074/jbc.M109031200 }}</ref>
* [[LGALS8]],<ref name=pmid10852818>{{cite journal | vauthors = Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y | title = Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis | journal = Journal of Cell Science | volume = 113 | issue = 13| pages = 2385–97 | date = Jul 2000 | pmid = 10852818 }}</ref>
* [[MAP4K4]],<ref name=pmid11967148>{{cite journal | vauthors = Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E | title = A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans | journal = Current Biology | volume = 12 | issue = 8 | pages = 622–31 | date = Apr 2002 | pmid = 11967148 | doi = 10.1016/S0960-9822(02)00764-9 }}</ref>
* [[NME1]],<ref name=pmid11919189>{{cite journal | vauthors = Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C | title = Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement | url = https://archive.org/details/sim_journal-of-biological-chemistry_2002-06-07_277_23/page/20894 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 23 | pages = 20895–902 | date = Jun 2002 | pmid = 11919189 | doi = 10.1074/jbc.M200200200 }}</ref>
* [[PKC alpha]],<ref name=pmid12435334>{{cite journal | vauthors = Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM | title = Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction | journal = Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society | volume = 10 | issue = 11 | pages = 890–7 | date = Nov 2002 | pmid = 12435334 | doi = 10.1053/joca.2002.0842 }}</ref><ref name=pmid12138200>{{cite journal | vauthors = Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T | title = Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis | url = https://archive.org/details/sim_molecular-and-cellular-biology_2002-08_22_16/page/5897 | journal = Molecular and Cellular Biology | volume = 22 | issue = 16 | pages = 5897–911 | date = Aug 2002 | pmid = 12138200 | pmc = 133968 | doi = 10.1128/MCB.22.16.5897-5911.2002 }}</ref>
* [[TLN1]],<ref>{{cite journal | vauthors = Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L | title = Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts | url = https://archive.org/details/sim_oncogene_1989-03_4_3/page/325 | journal = Oncogene | volume = 4 | issue = 3 | pages = 325–33 | date = Mar 1989 | pmid = 2468126 }}</ref><ref>{{cite journal | vauthors = Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K | title = Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage | journal = Nature | volume = 320 | issue = 6062 | pages = 531–3 | date = 1986 | pmid = 2938015 | doi = 10.1038/320531a0 }}</ref>
* [[TSPAN4]],<ref name=pmid9360996>{{cite journal | vauthors = Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME | title = NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins | url = https://archive.org/details/sim_journal-of-biological-chemistry_1997-11-14_272_46/page/29180 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 46 | pages = 29181–9 | date = Nov 1997 | pmid = 9360996 | doi = 10.1074/jbc.272.46.29181 }}</ref>
* [[YWHAB]]<ref name=pmid11313964>{{cite journal | vauthors = Han DC, Rodriguez LG, Guan JL | title = Identification of a novel interaction between integrin beta1 and 14-3-3beta | journal = Oncogene | volume = 20 | issue = 3 | pages = 346–57 | date = Jan 2001 | pmid = 11313964 | doi = 10.1038/sj.onc.1204068 }}</ref>
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== 参考文献 ==
{{reflist|33em}}
== 外部链接 ==
* {{MeshName|CD29+Antigen}}
* {{UCSC gene info|ITGB1}}

{{Clusters of differentiation}}
{{Integrins}}

[[Category:分化群]]
[[Category:位於10號人類染色體的基因]]
[[Category:整合素]]

CD29 - 版本历史

imported>InternetArchiveBot：​Add 9 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot

imported>InternetArchiveBot：Add 9 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot