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{{Infobox_gene}}
'''CD1a'''（'''C'''luster of '''D'''ifferentiation '''1a'''）是身上的一種人類[[蛋白质]]，由基因「{{gene|CD1A}}」轉譯而成<ref name="entrez">{{cite web | title = Entrez Gene: CD1A CD1a molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=909}}</ref>。

該蛋白屬於[[CD1|CD1蛋白家族]]，為一種穿膜醣蛋白。CD1a與[[β2-微球蛋白]]共同構成的異源二聚體（heterodimers）稱為「CD1a複合體」（CD1a complex），在結構上類似[[主要组织相容性复合体|MHC I分子]]。兩者都具有[[抗原呈現]]的能力，但CD1a主要呈現的是[[糖脂|糖脂類]]，而MHC分子主要呈現的是[[肽|多肽類]]。人類身上的CD1家族基因共有五個，且都集中排列在[[1號染色體]]上的某個區域<ref name="entrez" />。

==臨床意義==
在抽菸的病人身上，「''CD1A''」在肺間質的表現會較為顯著<ref name="pmid31506599">{{cite journal | vauthors = Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F | title = Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 13039 | date = September 2019 | pmid = 31506599 | pmc = 6736939 | doi = 10.1038/s41598-019-49648-2 | bibcode = 2019NatSR...913039P }}</ref>。

==參考文獻==
{{reflist}}

==外部連結==
* {{UCSC gene info|CD1A}}
* {{PDBe-KB2|P06126|Human T-cell surface glycoprotein CD1a}}

==延伸閱讀==
{{refbegin | 2}}
*{{cite journal | vauthors=Melián A, Beckman EM, Porcelli SA, Brenner MB |title=Antigen presentation by CD1 and MHC-encoded class I-like molecules. |journal=Curr. Opin. Immunol. |volume=8 |issue= 1 |pages= 82–8 |year= 1996 |pmid= 8729450 |doi=10.1016/S0952-7915(96)80109-9 }}
*{{cite journal | vauthors=Park SH, Bendelac A |title=CD1-restricted T-cell responses and microbial infection. | url=https://archive.org/details/sim_nature-uk_2000-08-17_406_6797/page/788 |journal=Nature |volume=406 |issue= 6797 |pages= 788–92 |year= 2000 |pmid= 10963609 |doi= 10.1038/35021233 |s2cid=4373172 }}
*{{cite journal | vauthors=Brigl M, Brenner MB |title=CD1: antigen presentation and T cell function. |journal=Annu. Rev. Immunol. |volume=22 |issue= 1|pages= 817–90 |year= 2004 |pmid= 15032598 |doi= 10.1146/annurev.immunol.22.012703.104608 }}
*{{cite journal | vauthors=Coventry B, Heinzel S |title=CD1a in human cancers: a new role for an old molecule. | url=https://archive.org/details/sim_trends-in-immunology_2004-05_25_5/page/242 |journal=Trends Immunol. |volume=25 |issue= 5 |pages= 242–8 |year= 2004 |pmid= 15099564 |doi= 10.1016/j.it.2004.03.002 }}
*{{cite journal | vauthors=Moody DB, Zajonc DM, Wilson IA |title=Anatomy of CD1-lipid antigen complexes. |journal=Nat. Rev. Immunol. |volume=5 |issue= 5 |pages= 387–99 |year= 2005 |pmid= 15864273 |doi= 10.1038/nri1605 |s2cid=1387491 }}
*{{cite journal | vauthors=Stove V, Verhasselt B |title=Modelling thymic HIV-1 Nef effects. |journal=Curr. HIV Res. |volume=4 |issue= 1 |pages= 57–64 |year= 2006 |pmid= 16454711 |doi=10.2174/157016206775197583 }}
*{{cite journal | vauthors=Quaranta MG, Mattioli B, Giordani L, Viora M |title=The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS. | url=https://archive.org/details/sim_faseb-journal_2006-11_20_13/page/2198 |journal=FASEB J. |volume=20 |issue= 13 |pages= 2198–208 |year= 2006 |pmid= 17077296 |doi= 10.1096/fj.06-6260rev |s2cid=3111709 }}
*{{cite journal | vauthors=Oakey RJ, Watson ML, Seldin MF |title=Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA. |journal=Hum. Mol. Genet. |volume=1 |issue= 8 |pages= 613–20 |year= 1993 |pmid= 1301170 |doi=10.1093/hmg/1.8.613 }}
*{{cite journal | vauthors=Martin LH, Calabi F, Lefebvre FA |title=Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 24 |pages= 9189–93 |year= 1988 |pmid= 2447586 |doi=10.1073/pnas.84.24.9189 | pmc=299718 |display-authors=etal|doi-access=free }}
*{{cite journal | vauthors=Moseley WS, Watson ML, Kingsmore SF, Seldin MF |title=CD1 defines conserved linkage group border between human chromosomes 1 and mouse chromosomes 1 and 3. | url=https://archive.org/details/sim_immunogenetics_1989-11_30_5/page/378 |journal=Immunogenetics |volume=30 |issue= 5 |pages= 378–82 |year= 1989 |pmid= 2478463 |doi=10.1007/BF02425278 |s2cid=9361881 }}
*{{cite journal | vauthors=Yu CY, Milstein C |title=A physical map linking the five CD1 human thymocyte differentiation antigen genes. |journal=EMBO J. |volume=8 |issue= 12 |pages= 3727–32 |year= 1990 |pmid= 2583117 |doi= 10.1002/j.1460-2075.1989.tb08548.x| pmc=402056 }}
*{{cite journal | vauthors=Aruffo A, Seed B |title=Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts. | url=https://archive.org/details/sim_journal-of-immunology_1989-09-01_143_5/page/1722 |journal=J. Immunol. |volume=143 |issue= 5 |pages= 1723–30 |year= 1989 |doi=10.4049/jimmunol.143.5.1723 |pmid= 2701945 |s2cid=23168239 }}
*{{cite journal | vauthors=Longley J, Kraus J, Alonso M, Edelson R |title=Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. | url=https://archive.org/details/sim_journal-of-investigative-dermatology_1989-04_92_4/page/628 |journal=J. Invest. Dermatol. |volume=92 |issue= 4 |pages= 628–31 |year= 1989 |pmid= 2784820 |doi=10.1111/1523-1747.ep12712175 |doi-access=free }}
*{{cite journal | vauthors=Albertson DG, Fishpool R, Sherrington P |title=Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. | url=https://archive.org/details/sim_embo-journal_1988-09_7_9/page/2801 |journal=EMBO J. |volume=7 |issue= 9 |pages= 2801–5 |year= 1988 |pmid= 3053166 |doi= 10.1002/j.1460-2075.1988.tb03135.x| pmc=457071 |display-authors=etal}}
*{{cite journal | vauthors=Calabi F, Milstein C |title=A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6. | url=https://archive.org/details/sim_nature-uk_1986-10-09_323_6088/page/540 |journal=Nature |volume=323 |issue= 6088 |pages= 540–3 |year= 1986 |pmid= 3093894 |doi= 10.1038/323540a0 |bibcode=1986Natur.323..540C |s2cid=4274219 }}
*{{cite journal | vauthors=Martin LH, Calabi F, Milstein C |title=Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 9154–8 |year= 1987 |pmid= 3097645 |doi=10.1073/pnas.83.23.9154 | pmc=387093 |doi-access=free }}
*{{cite journal | vauthors=Woolfson A, Milstein C |title=Alternative splicing generates secretory isoforms of human CD1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6683–7 |year= 1994 |pmid= 7517559 |doi=10.1073/pnas.91.14.6683 | pmc=44267 |bibcode=1994PNAS...91.6683W |doi-access=free }}
*{{cite journal |vauthors=Han M, Hannick LI, DiBrino M, Robinson MA |title=Polymorphism of human CD1 genes. |journal=Tissue Antigens |volume=54 |issue=2 |pages=122–7 |year=2000 |pmid=10488738 |doi=10.1034/j.1399-0039.1999.540202.x |url=https://zenodo.org/record/1231458 |access-date=2023-06-03 |archive-date=2023-04-11 |archive-url=https://web.archive.org/web/20230411042159/https://zenodo.org/record/1231458 |dead-url=no }}
*{{cite journal | vauthors=Sugita M, Grant EP, van Donselaar E |title=Separate pathways for antigen presentation by CD1 molecules. |journal=Immunity |volume=11 |issue= 6 |pages= 743–52 |year= 2000 |pmid= 10626896 |doi=10.1016/S1074-7613(00)80148-X |display-authors=etal|doi-access=free }}
{{refend}}
{{PDB Gallery|geneid=909}}

{{NLM content}}
{{Clusters of differentiation}}

[[Category:分化群]]

{{membrane-protein-stub}}

CD1A - 版本历史

imported>InternetArchiveBot：​Add 3 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot

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