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{{Infobox gene}}
'''整联蛋白β-2'''（{{langx|en|Integrin beta-2}}，'''CD18'''）是一个由人类[[基因]] ''ITGB2'' 编码的[[蛋白质]]，是整联蛋白的一种β亚基。

能与下列四种整联蛋白α亚基搭配形成四种整联蛋白：
* [[淋巴球功能性抗原1]]，LFA-1 (搭配 CD11a)
* 巨噬细胞抗原的1 (搭配 CD11b)
* 整联蛋白αXβ2 (搭配 CD11c)
* 整联蛋白αDβ2 (搭配 CD11d)

== 相互作用 ==
CD18已经与下列蛋白质[[蛋白質交互作用|进行交互作用]] ：
{{div col|cols=2}}
* [[FHL2]]<ref name = pmid10906324>{{cite journal | vauthors = Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M | title = The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes | url = https://archive.org/details/sim_journal-of-biological-chemistry_2000-10-27_275_43/page/33668 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 43 | pages = 33669–78 | date = October 2000 | pmid = 10906324 | doi = 10.1074/jbc.M002519200 }}</ref>
* [[GNB2L1]]<ref name = pmid9442085>{{cite journal | vauthors = Liliental J, Chang DD | title = Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit | url = https://archive.org/details/sim_journal-of-biological-chemistry_1998-01-23_273_4/page/2378 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 2379–83 | date = Jan 1998 | pmid = 9442085 | doi = 10.1074/jbc.273.4.2379}}</ref>
* [[ICAM-1]]<ref name = pmid10352278>{{cite journal | vauthors = Kotovuori A, Pessa-Morikawa T, Kotovuori P, Nortamo P, Gahmberg CG | title = ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity | url = https://archive.org/details/sim_journal-of-immunology_1999-06-01_162_11/page/6612 | journal = Journal of Immunology | volume = 162 | issue = 11 | pages = 6613–20 | date = June 1999 | pmid = 10352278 | doi = }}</ref><ref name = pmid11279101>{{cite journal | vauthors = Lu C, Takagi J, Springer TA | title = Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state | url = https://archive.org/details/sim_journal-of-biological-chemistry_2001-05-04_276_18/page/14642 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 18 | pages = 14642–8 | date = May 2001 | pmid = 11279101 | doi = 10.1074/jbc.M100600200 }}</ref><ref name = pmid7642561>{{cite journal | vauthors = Huang C, Springer TA | title = A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1) | url = https://archive.org/details/sim_journal-of-biological-chemistry_1995-08-11_270_32/page/19008 | journal = The Journal of Biological Chemistry | volume = 270 | issue = 32 | pages = 19008–16 | date = August 1995 | pmid = 7642561 | doi = 10.1074/jbc.270.32.19008}}</ref>
* [[PSCD1]]<ref name = pmid9765275>{{cite journal | vauthors = Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B | title = The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins | url = https://archive.org/details/sim_journal-of-biological-chemistry_1998-10-16_273_42/page/27458 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27459–66 | date = October 1998 | pmid = 9765275 | doi = 10.1074/jbc.273.42.27459}}</ref><ref name = pmid10835351>{{cite journal | vauthors = Geiger C, Nagel W, Boehm T, van Kooyk Y, Figdor CG, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber KS, Kolanus W | title = Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1 | url = https://archive.org/details/sim_embo-journal_2000-06-01_19_11/page/2524 | journal = The EMBO Journal | volume = 19 | issue = 11 | pages = 2525–36 | date = June 2000 | pmid = 10835351 | pmc = 212768 | doi = 10.1093/emboj/19.11.2525 }}</ref>
{{Div col end}}

== 参考文献 ==
{{reflist}}

== 延伸阅读 ==

== 外部链接 ==
* MeSH（醫學主題詞）<div class="cx-overlay"><div class="cx-spinner"><div class="bounce1"></div><div class="bounce2"></div><div class="bounce3"></div></div></div><span id="cxmwnw" tabindex="0">上面的</span>''[//www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&term=CD18+antigen CD18+antigen]''
* [https://web.archive.org/web/20110722014120/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&orth_acc=co00001789 ITGB2] 信息的链接在 [https://web.archive.org/web/20141211173306/http://www.cellmigration.org/index.shtml 单元的移徙网关]
* {{UCSC gene info|ITGB2}}

{{Clusters of differentiation}}
{{Cell adhesion molecules}}
{{整合素}}

[[Category:分化群]]
[[Category:位於21號人類染色體的基因]]
[[Category:整合素]]

CD18 - 版本历史

imported>InternetArchiveBot：​Add 7 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot

imported>InternetArchiveBot：Add 7 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot