https://arolstar52-zhtest.hf.space/index.php?action=history&feed=atom&title=CCL9CCL9 - 版本历史2026-07-14T23:26:03Z在这个wiki上该页的修订历史MediaWiki 1.43.9https://arolstar52-zhtest.hf.space/index.php?title=CCL9&diff=2251704&oldid=previmported>InternetArchiveBot：Add 3 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot2025-10-17T21:22:34Z<p>Add 3 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (<a href="/index.php?title=User:GreenC_bot&action=edit&redlink=1" class="new" title="User:GreenC bot（页面不存在）">GreenC bot</a></p>
<p><b>新页面</b></p><div>{{PBB|geneid=20308}}<br />
'''CCL9'''（{{langx|en|Chemokine (C-C motif) ligand 9}}）是一个小型的[[细胞因子]]，属于CC[[趋化因子]]家族。它的别名有巨噬细胞炎性蛋白-1γ（{{langx|en|''macrophage inflammatory protein-1 gamma''}}，'''MIP-1γ'''）, 巨噬细胞炎症蛋白相关蛋白-2（{{langx|en|''macrophage inflammatory protein-related protein-2''}}，'''MRP-2'''）以及在啮齿类中使用的'''CCF18'''。CCL9还曾经被定名为'''CCL10'''，但这个名称已不再使用。<br />
<br />
它由[[淋巴结]]相关[[上皮组织]]（FAE）分泌（如{{le|Peyer氏斑块|Peyer's patch}}周围），并影响拥有细胞表面分子[[Integrin alpha M|CD11b]]与[[趋化因子受体]][[CCR1]]的[[树突状细胞]]<ref>{{cite journal |author=Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A |title=CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells |url=https://archive.org/details/sim_journal-of-immunology_2003-09-15_171_6/page/2796 |journal=J Immunol |volume=171 |issue=6 |pages=2797–803 |year=2003 |pmid=12960300}}</ref>。 CCL9 通过其受体CCR1（破骨细胞中最丰富的趋化因子受体）激活[[破骨细胞]]，表明了CCL9可能在{{le|骨质吸收|bone resorption}}中的重要作用<ref>{{cite journal |author=Lean J, Murphy C, Fuller K, Chambers T |title=CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts |journal=J Cell Biochem |volume=87 |issue=4 |pages=386–93 |year=2002 |pmid=12397598 |doi=10.1002/jcb.10319}}</ref>。CCL9[[巨噬细胞]]和[[骨髓]]细胞里也持续表达<ref>{{cite journal |author=Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B |title=A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors |url=https://archive.org/details/sim_journal-of-immunology_1995-09-01_155_5/page/2660 |journal=J Immunol |volume=155 |issue=5 |pages=2661–7 |year=1995 |pmid=7650394}}</ref><ref name = hara>{{cite journal |author=Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A |title=Molecular cloning and functional characterization of a novel member of the C-C chemokine family |url=https://archive.org/details/sim_journal-of-immunology_1995-12-01_155_11/page/5352 |journal=J Immunol |volume=155 |issue=11 |pages=5352–8 |year=1995 |pmid=7594550}}</ref>。编码CCL9的[[基因]]位于小鼠的11号[[染色体]]上<ref name = hara/>。<br />
<br />
==参考文献==<br />
{{Reflist}}<br />
<br />
{{细胞因子}}<br />
<br />
[[Category:细胞因子]]<br />
<br />
<br />
{{protein-stub}}</div>imported>InternetArchiveBot