https://arolstar52-zhtest.hf.space/index.php?action=history&feed=atom&title=CCL12 2026-07-17T12:58:21Z 在这个wiki上该页的修订历史 MediaWiki 1.43.9 https://arolstar52-zhtest.hf.space/index.php?title=CCL12&diff=2251881&oldid=prev 2025-10-17T21:21:50Z

<p>Add 1 book for verifiability (20251017sim)) #IABot (v2.0.9.5) (<a href="/index.php?title=User:GreenC_bot&amp;action=edit&amp;redlink=1" class="new" title="User:GreenC bot（页面不存在）">GreenC bot</a></p> <p><b>新页面</b></p><div>{{PBB|geneid=20293}}<br /> <br /> &#039;&#039;&#039;CCL12&#039;&#039;&#039;（{{langx|en|Chemokine (C-C motif) ligand 12}}）是一个小型的[[细胞因子]]，属于CC[[趋化因子]]家族，最早在鼠类中发现。它还被叫做单核细胞趋化蛋白5（{{langx|en|&#039;&#039;monocyte chemotactic protein 5&#039;&#039;}}，&#039;&#039;&#039;MCP-5&#039;&#039;&#039;），又由于其和人类趋化因子[[CCL2|MCP-1]]的相似性，有时候也被称为MCP-1相关趋化因子（{{langx|en|&#039;&#039;MCP-1-related chemokine&#039;&#039;}}）。CCL12特异性影响[[嗜酸性粒細胞]]、[[单核细胞]]和[[淋巴细胞]]&lt;ref name = jia&gt;{{cite journal |author=Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J |title=Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation |url=https://archive.org/details/sim_journal-of-experimental-medicine_1996-11_184_5/page/1939 |journal=J Exp Med |volume=184 |issue=5 |pages=1939–51 |year=1996 |pmid=8920881 |doi=10.1084/jem.184.5.1939 |pmc=2192876}}&lt;/ref&gt;。这个趋化因子正常情况下存在于[[淋巴结]]和[[胸腺]]中，其表达能显著诱导巨噬细胞&lt;ref name = jia/&gt;&lt;ref name=sarafi&gt;{{cite journal |author=Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A |title=Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1 |url=https://archive.org/details/sim_journal-of-experimental-medicine_1997-01-06_185_1/page/n117 |journal=J Exp Med |volume=185 |issue=1 |pages=99–109 |year=1997 |pmid=8996246 |doi=10.1084/jem.185.1.99 |pmc=2196097}}&lt;/ref&gt;。编码CCL12的[[基因]]发现于小鼠[[染色体]]11上&lt;ref name=sarafi/&gt;。<br /> <br /> ==参考文献==<br /> {{Reflist}}<br /> <br /> {{细胞因子}}<br /> <br /> [[Category:细胞因子]]<br /> <br /> <br /> {{protein-stub}}</div>

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