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CCL1 - 版本历史
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<p><b>新页面</b></p><div>{{protein<br />
| Name = 趋化因子（C-C基序）配体1<br />
| caption = <br />
| image = <br />
| width = <br />
| HGNCid = 10609<br />
| Symbol = CCL1<br />
| AltSymbols = SCYA1, I-309, TCA3, P500, SISe<br />
| EntrezGene = 6346<br />
| OMIM = 182281<br />
| RefSeq = NM_002981<br />
| UniProt = P22362<br />
| PDB = 1EL0<br />
| ECnumber = <br />
| Chromosome = 17<br />
| Arm = q<br />
| Band = 11.2<br />
| LocusSupplementaryData = <br />
}}<br />
'''CCL1'''（{{langx|en|Chemokine (C-C motif) ligand 1}}）是一小分子的[[细胞因子]]属于CC[[趋化因子]]家族，是由活化的[[T细胞]]分泌的[[糖蛋白]]<ref name=miller>Miller MD, Krangel MS. The human cytokine I-309 is a monocyte chemoattractant. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2950-4.</ref>。CCL1与细胞表面的趋化因子受体[[CCR8]]结合<ref>Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B. Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem. 1997 Jul 11;272(28):17251-4.</ref>。CCL1对[[单核细胞]]，[[自然杀伤细胞]]，未成熟的[[B细胞]]和[[树突状细胞]]有细胞趋化作用<ref name=miller/>。人类的CCL1[[基因]]与许多CC趋化因子的基因相邻聚集在第17染色体上<ref>Miller MD, Wilson SD, Dorf ME, Seuanez HN, O'Brien SJ, Krangel MS. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. J Immunol. 1990 Oct 15;145(8):2737-44.</ref>.<br />
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== 参见 ==<br />
* [[趋化因子]]<br />
* [[CCR8]]<br />
<br />
== 参考文献 ==<br />
{{Reflist}}<br />
<br />
== 外部链接 ==<br />
* [http://content.nejm.org/cgi/content/extract/354/6/610 Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.]{{Wayback|url=http://content.nejm.org/cgi/content/extract/354/6/610 |date=20070110225703 }}<br />
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{{细胞因子}}<br />
<br />
[[Category:细胞因子]]<br />
[[Category:免疫学]]</div>
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