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BW247 - 版本历史
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<p><b>新页面</b></p><div>{{Infobox drug<br />
| drug_name = BW 247<br />
| image = BW 247.svg<br />
| width = 250px<br />
| caption =<br />
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<!-- Identifiers --><br />
| CAS_number = 21912-88-9<br />
| CAS_supplemental = <br />
| PubChem = 89549<br />
| IUPHAR_ligand = <br />
| DrugBank = <br />
| ChemSpiderID = 80819<br />
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| C=16 | H=17 | N=1<br />
| smiles = CNCC=C(C1=CC=CC=C1)C2=CC=CC=C2<br />
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'''BW-247'''是一种含氮有机化合物，分子式[[C16H17N|{{chem2|C16H17N}}]]，属于一种[[仲胺]]，可用作[[抗抑郁药]]<ref>{{cite journal | vauthors = Castañer J, Roberts PJ | date = 1979 | title = BW-247 | journal = Drugs of the Future | volume = 4 | issue = 2 | pages = 92 | doi = 10.1358/dof.1979.004.02.1002432 }}</ref><ref name="pmid3310107">{{cite journal | vauthors = Ankier SI | title = Recent progress in the development of new antidepressant drugs | journal = Progress in Medicinal Chemistry | volume = 23 | issue = | pages = 121–85 | date = 1986 | pmid = 3310107 | doi = 10.1016/s0079-6468(08)70342-4 | isbn = 978-0-444-80802-8 }}</ref>。<!--，BW-247is a secondary amine, closely related in structure to the tricyclic antidepressants, which inhibits NA uptake in aortic strips<ref name="pmid5776989">{{cite journal | vauthors = Maxwell RA, Keenan PD, Chaplin E, Roth B, Eckhardt SB | title = Molecular features affecting the potency of tricyclic antidepressants and structurally related compounds as inhibitors of the uptake of tritiated norepinephrine by rabbit aortic strips | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 166 | issue = 2 | pages = 320–329 | date = April 1969 | pmid = 5776989 | doi = 10.1016/S0022-3565(25)28238-6| url = https://jpet.aspetjournals.org/article/S0022-3565(25)28238-6/abstract }}</ref> and rat cerebral cortex slices.<ref name="pmid5571898">{{cite journal | vauthors = Salama AI, Insalaco JR, Maxwell RA | title = Concerning the molecular requirements for the inhibition of the uptake of racemic 3 H-norepinephrine into rat cerebral cortex slices by tricyclic antidepressants and related compounds | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 178 | issue = 3 | pages = 474–81 | date = September 1971 | pmid = 5571898 | doi = 10.1016/S0022-3565(25)28980-7| url = https://jpet.aspetjournals.org/article/S0022-3565(25)28980-7/abstract }}</ref> Unlike the tricyclic antidepressants, it is reported not to possess anticholinergic activity.<ref name="pmid1250062">{{cite journal | vauthors = Bridges JW, Dent JG, Johnson P | title = The effects of some pharmacologically active amines on the rate of gastric emptying in rats | journal = Life Sciences | volume = 18 | issue = 1 | pages = 97–107 | date = January 1976 | pmid = 1250062 | doi = 10.1016/0024-3205(76)90279-4 }}</ref><br />
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==另见==<br />
*[[DPH-362]]<br />
<br />
== 参考文献 ==<br />
{{reflist}}<br />
<br />
{{Antidepressants}}<br />
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[[Category:去甲肾上腺素重摄取抑制剂]]<br />
[[Category:仲胺]]</div>
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