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BMS-202 - 版本历史
2026-07-16T13:31:40Z
在这个wiki上该页的修订历史
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imported>Htmlzycq：使用HotCat已添加Category:仲胺
2025-04-10T06:55:48Z
<p>使用<a href="/index.php?title=WP:HOTCAT&action=edit&redlink=1" class="new" title="WP:HOTCAT（页面不存在）">HotCat</a>已添加<a href="/wiki/Category:%E4%BB%B2%E8%83%BA" title="Category:仲胺">Category:仲胺</a></p>
<p><b>新页面</b></p><div>{{Drugbox<br />
| Verifiedfields = <br />
| verifiedrevid = <br />
| IUPAC_name = ''N''-(2-(((2-methoxy-6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)pyridin-3-yl)methyl)amino)ethyl)acetamide<br />
| image = BMS-202.svg<br />
| width = 300<br />
<br />
<!--Clinical data--><br />
| tradename =<br />
| legal_status = Investigational<br />
<br />
<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|??}}<br />
| CAS_number = 1675203-84-5<br />
| ATC_prefix = none<br />
| PubChem = 117951478<br />
| ChemSpiderID = 45743495<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = KDA2HUE7KP<br />
| IUPHAR_ligand = 9607<br />
| ChEBI_Ref = <br />
| ChEBI =<br />
| ChEMBL_Ref = {{ebicite|correct|EBI}}<br />
| ChEMBL = 4089730<br />
<br />
<!--Chemical data--><br />
| C=25 | H=29 | N=3 | O=3<br />
| smiles = CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC(=C(C=C3)CNCCNC(=O)C)OC <br />
| StdInChI = 1S/C25H29N3O3/c1-18-22(10-7-11-23(18)20-8-5-4-6-9-20)17-31-24-13-12-21(25(28-24)30-3)16-26-14-15-27-19(2)29/h4-13,26H,14-17H2,1-3H3,(H,27,29)<br />
| StdInChIKey = JEDPSOYOYVELLZ-UHFFFAOYSA-N <br />
}}<br />
'''{{PAGENAME}}'''是一种[[氮化合物|含氮]][[有机化合物]]，分子式[[C25H29N3O3|{{chem2|C25H29N3O3}}]]，为[[百时美施贵宝]]研发的[[小分子]][[PD-1/PD-L1抑制剂]]，用于治疗[[胶质母细胞瘤]]（GBM）<ref>{{cite journal | journal = Immunity, Inflammation and Disease | title = BMS-202, a PD-1/PD-L1 inhibitor, decelerates the pro‑fibrotic effects of fibroblasts derived from scar tissues via ERK and TGFβ1/Smad signaling pathways | date = 2022 | doi = 10.1002/iid3.693 | volume = 10 | issue = 10 | pages = e693 | pmid = 36169254 | pmc = 9449589 | vauthors = Cai Y, Xiao M, Li X, Zhou S, Sun Y, Yu W, Zhao T }}</ref><ref>{{cite journal | journal = Biomedical Research | title = Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse | date = 2019 | doi = 10.2220/biomedres.40.243 | volume = 40 | issue = 6 | pages = 243–250 | pmid = 31839668 | vauthors = Ashizawa T, Iizuka A, Tanaka E, Kondou R, Miyata H, Maeda C, Sugino T, Yamaguchi K, Ando T, Ishikawa Y, Ito M, Akiyama Y | doi-access = free }}</ref>。<br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:联苯]]<br />
[[Category:甲氧基化合物]]<br />
[[Category:吡啶]]<br />
[[Category:乙酰胺]]<br />
[[Category:仲胺]]</div>
imported>Htmlzycq