imported>Nucleus hydro elemon：使用HotCat已添加Category:烟碱激动剂

2024-02-19T00:26:54Z

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{{Chembox
| Verifiedfields = changed
| verifiedrevid = 477236447
| Name =
| ImageFile = AR-R17779 Structure.svg
| ImageSize = 150px
| ImageFile2 = AR-R17779 molecule ball.png
| IUPACName = (2''S'')-4′-Azaspiro[bicyclo[2.2.2]octane-2,5′-[1,3]oxazolidin]-2′-one
| OtherNames = (−)-Spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one]
|Section1={{Chembox Identifiers
| Abbreviations =
| InChI = 1/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 193016
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = TYAGAVRSOFABFO-VIFPVBQEBZ
| CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 178419-47-1
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = C3VZ57BN3M
| EINECS =
| PubChem = 5310971
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4470515
| SMILES = O=C3O[C@]1(CN2CCC1CC2)CN3
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1
| RTECS =
| MeSHName =
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = CHEBI:420311
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG =
}}
|Section2={{Chembox Properties
| C=9 | H=14 | N=2 | O=2
| Appearance =
| Density =
| MeltingPt =
| MeltingPt_notes =
| BoilingPt =
| BoilingPt_notes =
| Solubility =
| SolubleOther =
| Solvent =
| LogP =
| VaporPressure =
| HenryConstant =
| AtmosphericOHRateConstant =
| pKa =
| pKb =
}}
|Section5={{Chembox Pharmacology
| AdminRoutes =
| Bioavail =
| Metabolism =
| HalfLife =
| ProteinBound =
| Excretion =
| Legal_status =
| Legal_US =
| Legal_UK =
| Legal_AU =
| Legal_CA =
| Pregnancy_category =
| Pregnancy_AU =
| Pregnancy_US =
}}
|Section7={{Chembox Hazards
| ExternalSDS =
| MainHazards =
| NFPA-H =
| NFPA-F =
| NFPA-R =
| NFPA-S =
| FlashPt =
| AutoignitionPt =
| ExploLimits =
| LD50 =
| PEL =
}}
|Section8={{Chembox Related
| OtherAnions =
| OtherCations =
| OtherFunction =
| OtherFunction_label =
| OtherCompounds =
}}
}}
'''AR-R17779'''，分子式[[C9H14N2O2|C9H14N2O2]]，是[[CHRNA7|α7]][[菸鹼型乙醯膽鹼受體]]的完全[[激动剂]]<ref>{{Cite journal
| pmid = 11063601
| year = 2000
| last1 = Mullen | first1 = G.
| last2 = Napier | first2 = A.
| last3 = Balestra | first3 = M.
| last4 = Decory | first4 = T.
| last5 = Hale | first5 = G.
| last6 = Macor | first6 = J.
| last7 = Mack | first7 = R.
| last8 = Loch | first8 = J.
| last9 = Wu | first9 = E.
| last10 = Kover | first10 = A.
| last11 = Verhoest | first11 = P.
| last12 = Sampognaro | first12 = A.
| last13 = Phillips | first13 = E.
| last14 = Zhu | first14 = Y.
| last15 = Murray | first15 = R.
| last16 = Griffith | first16 = R.
| last17 = Blosser | first17 = J.
| last18 = Gurley | first18 = D.
| last19 = Machulskis | first19 = A.
| last20 = Zongrone | first20 = J.
| last21 = Rosen | first21 = A.
| last22 = Gordon | first22 = J.
| title = (−)-Spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor
| volume = 43
| issue = 22
| pages = 4045–4050
| journal = [[Journal of Medicinal Chemistry]]
| doi = 10.1021/jm000249r
}}</ref><ref>{{Cite journal
| last1 = Macor | first1 = J.
| last2 = Mullen | first2 = G.
| last3 = Verhoest | first3 = P.
| last4 = Sampognaro | first4 = A.
| last5 = Shepardson | first5 = B.
| last6 = Mack | first6 = R.
| title = A chiral synthesis of (−)-spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one]: A conformationally restricted analogue of acetylcholine that is a potent and selective α7 nicotinic receptor agonist
| journal = The Journal of Organic Chemistry
| volume = 69
| issue = 19
| pages = 6493–6495
| year = 2004
| pmid = 15357617
| doi = 10.1021/jo049404q
}}</ref>。

== 参考文献 ==
{{Reflist|2}}

== 外部链接 ==
{{chem-stub}}

[[Category:兴奋剂]]
[[Category:促智药]]
[[Category:螺环化合物]]
[[Category:烟碱激动剂]]

AR-R17779 - 版本历史

imported>Nucleus hydro elemon：​使用HotCat已添加Category:烟碱激动剂

imported>Nucleus hydro elemon：使用HotCat已添加Category:烟碱激动剂