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APINACA - 版本历史
2026-07-13T15:25:04Z
本wiki上该页面的版本历史
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imported>Yubau：補充 PubChem CID 57404063（依英文條目及 PubChem 資料）
2026-04-19T00:55:22Z
<p>補充 PubChem CID 57404063（依英文條目及 PubChem 資料）</p>
<p><b>新页面</b></p><div>{{expand|time=2017-12-24T17:23:18+00:00}}<br />
{{Drugbox<br />
| IUPAC_name = 1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-1H-indazole-3-carboxamide <br />
| image = APINACA.svg<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII --><br />
| legal_UK = <!-- GSL / P / POM / CD / Class A, B, C --><br />
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --><br />
| legal_status = Temporary Class Drug (NZ), illegal in Japan<br />
| routes_of_administration = <br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
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<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|CAS}}<br />
| CAS_number = 1345973-53-6<br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| PubChem = 57404063<br />
| smiles = C3C4CC2CC3CC(C4)(C2)NC(=O)c(nn1CCCCC)c5c1cccc5<br />
<br />
<!--Chemical data--><br />
| C=23 | H=31 | N=3 | O=1 <br />
}}<br />
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'''APINACA'''（'''N-(1-金刚烷)-1-戊基-1H-吲唑-3-甲酰胺'''）是一种潜在的[[大麻素]][[受体]][[激动剂]]，在黑市上以日本女团“[[AKB48]]”的名字销售。此前它从未在科学界或专利文献中被报道过，2012年3月在日本的实验室中作为[[合成大麻]]混合烟的原料被识别出来<ref>{{cite journal|author1=Nahoko Uchiyama|author2=Maiko Kawamura|author3=Ruri Kikura-Hanajiri|author4=Yukihiro Goda|title=Identification of two new-type synthetic cannabinoids, N-(1-adamantyl)-1-pentyl-1H-indole-3-carboxamide (APICA) and N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide (APINACA), and detection of five synthetic cannabinoids, AM-1220, AM-2233, AM-1241, CB-13 (CRA-13), and AM-1248, as designer drugs in illegal products|journal=Forensic Toxicology|date=2012-04-10|volume=30|issue=2|pages=114–125|doi=10.1007/s11419-012-0136-7}}</ref>。结构上它类似于专利号为[http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2003035005 WO 2003/035005]{{Wayback|url=http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2003035005 |date=20131204000422 }}的大麻素化合物，除了吲唑1位上引入了一条戊烷基链，因而APINACA应属于该专利所涵盖的范围，尽管尚未作为实例得到确认。APINACA于2012年在日本被宣布为非法药物<ref>{{Cite web |url=http://members.wto.org/crnattachments/2012/tbt/JPN/12_1575_00_e.pdf |title=Designation of “Shitei Yakubutsu” (designated substances) based on the provision of the Pharmaceutical Affairs Law (1960, Law No.145) |accessdate=2012-07-17 |archive-date=2019-02-15 |archive-url=https://web.archive.org/web/20190215111916/https://members.wto.org/crnattachments/2012/tbt/JPN/12_1575_00_e.pdf |dead-url=no }}</ref>，从2012年7月13日起作为临时类毒品在新西兰被禁止<ref>{{Cite web |url=http://www.dia.govt.nz/MSOS118/On-Line/NZGazette.nsf/6cee7698a9bbc7cfcc256d510059ed0b/1800482ea20e00f8cc257a32005ae9f8!OpenDocument |title=Temporary Class Drug Notice, 05 July 2012. NZ Department of Internal Affairs. |accessdate=2012-07-17 |archive-date=2013-06-15 |archive-url=https://web.archive.org/web/20130615155240/http://www.dia.govt.nz/MSOS118/On-Line/NZGazette.nsf/6cee7698a9bbc7cfcc256d510059ed0b/1800482ea20e00f8cc257a32005ae9f8!OpenDocument |dead-url=no }}</ref>。<br />
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== 参见 ==<br />
* [[大麻素]]<br />
* [[精神药品]]<br />
<br />
== 参考文献 ==<br />
{{reflist}}<br />
<br />
[[Category:精神药物]]<br />
[[Category:金刚烷基化合物]]<br />
[[Category:吲唑甲酰胺]]</div>
imported>Yubau