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{{Infobox_gene}}
'''1B型激活素受体'''（Activin receptor type-1B），缩写为'''ACVR1B'''或'''ALK-4'''，在人体中是一种由''ACVR1B''[[基因]][[基因表达|编码]]的蛋白质<ref name="pmid8397373">{{cite journal | vauthors = ten Dijke P, Ichijo H, Franzén P, Schulz P, Saras J, Toyoshima H, Heldin CH, Miyazono K | title = Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity | url = https://archive.org/details/sim_oncogene_1993-10_8_10/page/2879 | journal = Oncogene | volume = 8 | issue = 10 | pages = 2879-87 | date = October 1993 | pmid = 8397373 | pmc = | doi = }}</ref><ref name="entrez">{{cite web| title = Entrez Gene: ACVR1B activin A receptor, type IB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91| accessdate = | archive-date = 2019-09-18| archive-url = https://web.archive.org/web/20190918234327/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=91| dead-url = no}}</ref>。

ALK-4能够对[[激活素]]或激活素样配体（即[[激活素与抑制素|抑制素]]）的信号进行转导。激活素首先与{{Link-en|ACVR2A|ACVR2A}}或{{Link-en|ACVR2B|ACVR2B}}结合，之后再与ALK-4形成复合物。上述过程能够招募{{link-en|R-SMAD|R-SMAD}}、{{link-en|SMAD2|SMAD2}}或者{{link-en|SMAD3|SMAD3}}分子<ref name="pmid12065756">{{cite journal | vauthors = Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS | title = SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 | journal = Mol. Pharmacol. | volume = 62 | issue = 1 | pages = 65-74 | year = 2002 | pmid = 12065756 | doi = 10.1124/mol.62.1.65 }}</ref>。ALK-4也可以转导{{Link-en|NODAL蛋白|NODAL|NODAL}}、GDF-1、Vg1的信号。但是，和激活素不同，这些分子（与ALK-4的结合）需要{{link-en|Cripto|Cripto}}蛋白等共受体<ref name="pmid12665502">{{cite journal | vauthors = Harrison CA, Gray PC, Koerber SC, Fischer W, Vale W | title = Identification of a functional binding site for activin on the type I receptor ALK4 | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-06-06_278_23/page/21128 | journal = J. Biol. Chem. | volume = 278 | issue = 23 | pages = 21129-35 | year = 2003 | pmid = 12665502 | doi = 10.1074/jbc.M302015200 }}</ref>。

==功能==
激活素是一类二聚体生长分化因子，属于[[轉化生長因子-β|TGF-β]]蛋白质超家族，一类结构上相关的信号蛋白。激活素信号能够通过一个包含至少两分子1型以及两分子2型受体的受体丝氨酸激酶异聚复合体进行转导。这些受体都属于跨膜蛋白，包含一个含有丰富[[半胱氨酸]]区域的[[细胞外]]配体结合[[结构域]]，一个跨膜结构域，以及一个推测具有丝氨酸或苏氨酸专一性的细胞内（即细胞质中的）（激酶）结构域。1型受体对信号转导来说是必要的，2型受体则对1型受体的表达以及配体的结合来说不可或缺。在配体结合后，1型受体以及2型受体能够形成一个稳定的复合物，并使1型受体被2型受体[[磷酸化]]<ref name="entrez"/>。

==基因结构与表达==
编码ALK-4基因含有11个外含子。[[可变剪接]]以及Poly(A)（多聚腺嘌呤）尾巴的变化使该基因拥有多个转录本，目前已有3个转录本得到阐明，另外，此基因可能存在第四个包含8号[[外显子]]，且8号外显子与11号外显子缺乏9号外显子的转录本，但是这种转录本对应的[[mRNA]]还没有得到确认<ref name="entrez"/>。

== 相互作用 ==
ALK能与ACVR2A、ACVR2B发生[[蛋白質交互作用|相互作用]]<ref name = pmid9892009>{{cite journal | vauthors = Lebrun JJ, Takabe K, Chen Y, Vale W | title = Roles of pathway-specific and inhibitory Smads in activin receptor signaling | journal = Mol. Endocrinol. | volume = 13 | issue = 1 | pages = 15-23 | date = January 1999 | pmid = 9892009 | doi = 10.1210/mend.13.1.0218 }}</ref><ref name = pmid8622651>{{cite journal | vauthors = Attisano L, Wrana JL, Montalvo E, Massagué J | title = Activation of signalling by the activin receptor complex | url = https://archive.org/details/sim_molecular-and-cellular-biology_1996-03_16_3/page/1066 | journal = Mol. Cell. Biol. | volume = 16 | issue = 3 | pages = 1066-73 | date = March 1996 | pmid = 8622651 | pmc = 231089 | doi = }}</ref><ref name = pmid8612709>{{cite journal | vauthors = De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ | title = Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors | journal = Exp. Cell Res. | volume = 224 | issue = 2 | pages = 323-34 | date = May 1996 | pmid = 8612709 | doi = 10.1006/excr.1996.0142 }}</ref>。

==参考==
{{reflist}}

==拓展阅读==
{{refbegin | 2}}
* {{cite journal | vauthors = Welt CK | title = The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction | journal = Curr. Opin. Obstet. Gynecol. | volume = 14 | issue = 3 | pages = 317-23 | year = 2002 | pmid = 12032389 | doi = 10.1097/00001703-200206000-00012 }}
* {{cite journal | vauthors = Liu F, Ventura F, Doody J, Massagué J | title = Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs | url = https://archive.org/details/sim_molecular-and-cellular-biology_1995-07_15_7/page/3479 | journal = Mol. Cell. Biol. | volume = 15 | issue = 7 | pages = 3479-86 | year = 1995 | pmid = 7791754 | pmc = 230584 | doi = 10.1128/mcb.15.7.3479}}
* {{cite journal | vauthors = Xu J, Matsuzaki K, McKeehan K, Wang F, Kan M, McKeehan WL | title = Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 17 | pages = 7957-61 | year = 1994 | pmid = 8058741 | pmc = 44523 | doi = 10.1073/pnas.91.17.7957 }}
* {{cite journal | vauthors = Cárcamo J, Weis FM, Ventura F, Wieser R, Wrana JL, Attisano L, Massagué J | title = Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin | url = https://archive.org/details/sim_molecular-and-cellular-biology_1994-06_14_6/page/n291 | journal = Mol. Cell. Biol. | volume = 14 | issue = 6 | pages = 3810-21 | year = 1994 | pmid = 8196624 | pmc = 358748 | doi = }}
* {{cite journal | vauthors = De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ | title = Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors | journal = Exp. Cell Res. | volume = 224 | issue = 2 | pages = 323-34 | year = 1996 | pmid = 8612709 | doi = 10.1006/excr.1996.0142 }}
* {{cite journal | vauthors = Attisano L, Wrana JL, Montalvo E, Massagué J | title = Activation of signalling by the activin receptor complex | url = https://archive.org/details/sim_molecular-and-cellular-biology_1996-03_16_3/page/1066 | journal = Mol. Cell. Biol. | volume = 16 | issue = 3 | pages = 1066-73 | year = 1996 | pmid = 8622651 | pmc = 231089 | doi = }}
* {{cite journal | vauthors = Lebrun JJ, Vale WW | title = Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation | url = https://archive.org/details/sim_molecular-and-cellular-biology_1997-03_17_3/page/1682 | journal = Mol. Cell. Biol. | volume = 17 | issue = 3 | pages = 1682-91 | year = 1997 | pmid = 9032295 | pmc = 231893 | doi = }}
* {{cite journal | vauthors = Röijer E, Miyazono K, Aström AK, Geurts van Kessel A, ten Dijke P, Stenman G | title = Chromosomal localization of three human genes encoding members of the TGF-beta superfamily of type I serine/threonine kinase receptors | journal = Mamm. Genome | volume = 9 | issue = 3 | pages = 266-8 | year = 1998 | pmid = 9501322 | doi = 10.1007/s003359900745 }}
* {{cite journal | vauthors = Souchelnytskyi S, Nakayama T, Nakao A, Morén A, Heldin CH, Christian JL, ten Dijke P | title = Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors | url = https://archive.org/details/sim_journal-of-biological-chemistry_1998-09-25_273_39/page/25364 | journal = J. Biol. Chem. | volume = 273 | issue = 39 | pages = 25364-70 | year = 1998 | pmid = 9738003 | doi = 10.1074/jbc.273.39.25364 }}
* {{cite journal | vauthors = Hashimoto O, Yamato K, Koseki T, Ohguchi M, Ishisaki A, Shoji H, Nakamura T, Hayashi Y, Sugino H, Nishihara T | title = The role of activin type I receptors in activin A-induced growth arrest and apoptosis in mouse B-cell hybridoma cells | journal = Cell. Signal. | volume = 10 | issue = 10 | pages = 743-9 | year = 1998 | pmid = 9884026 | doi = 10.1016/S0898-6568(98)00021-7 }}
* {{cite journal | vauthors = Lebrun JJ, Takabe K, Chen Y, Vale W | title = Roles of pathway-specific and inhibitory Smads in activin receptor signaling | journal = Mol. Endocrinol. | volume = 13 | issue = 1 | pages = 15-23 | year = 1999 | pmid = 9892009 | doi = 10.1210/mend.13.1.0218 }}
* {{cite journal | vauthors = Gray PC, Greenwald J, Blount AL, Kunitake KS, Donaldson CJ, Choe S, Vale W | title = Identification of a binding site on the type II activin receptor for activin and inhibin | url = https://archive.org/details/sim_journal-of-biological-chemistry_2000-02-04_275_5/page/3206 | journal = J. Biol. Chem. | volume = 275 | issue = 5 | pages = 3206-12 | year = 2000 | pmid = 10652306 | doi = 10.1074/jbc.275.5.3206 }}
* {{cite journal | vauthors = Zhou Y, Sun H, Danila DC, Johnson SR, Sigai DP, Zhang X, Klibanski A | title = Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling | journal = Mol. Endocrinol. | volume = 14 | issue = 12 | pages = 2066-75 | year = 2000 | pmid = 11117535 | doi = 10.1210/me.14.12.2066 }}
* {{cite journal | vauthors = Su GH, Bansal R, Murphy KM, Montgomery E, Yeo CJ, Hruban RH, Kern SE | title = ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 6 | pages = 3254-7 | year = 2001 | pmid = 11248065 | pmc = 30640 | doi = 10.1073/pnas.051484398 }}
* {{cite journal | vauthors = Chapman SC, Woodruff TK | title = Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP) | journal = Mol. Endocrinol. | volume = 15 | issue = 4 | pages = 668-79 | year = 2001 | pmid = 11266516 | doi = 10.1210/me.15.4.668 }}
* {{cite journal | vauthors = Wurthner JU, Frank DB, Felici A, Green HM, Cao Z, Schneider MD, McNally JG, Lechleider RJ, Roberts AB | title = Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone | url = https://archive.org/details/sim_journal-of-biological-chemistry_2001-06-01_276_22/page/19494 | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19495-502 | year = 2001 | pmid = 11278302 | doi = 10.1074/jbc.M006473200 }}
* {{cite journal | vauthors = Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ | title = Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases | url = https://archive.org/details/sim_journal-of-biological-chemistry_2001-06-01_276_22/page/19332 | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19332-9 | year = 2001 | pmid = 11279102 | doi = 10.1074/jbc.M100606200 }}
* {{cite journal | vauthors = Birkey Reffey S, Wurthner JU, Parks WT, Roberts AB, Duckett CS | title = X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling | url = https://archive.org/details/sim_journal-of-biological-chemistry_2001-07-13_276_28/page/26542 | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 26542-9 | year = 2001 | pmid = 11356828 | doi = 10.1074/jbc.M100331200 }}
* {{cite journal | vauthors = Bianco C, Adkins HB, Wechselberger C, Seno M, Normanno N, De Luca A, Sun Y, Khan N, Kenney N, Ebert A, Williams KP, Sanicola M, Salomon DS | title = Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells | url = https://archive.org/details/sim_molecular-and-cellular-biology_2002-04_22_8/page/2586 | journal = Mol. Cell. Biol. | volume = 22 | issue = 8 | pages = 2586-97 | year = 2002 | pmid = 11909953 | pmc = 133714 | doi = 10.1128/MCB.22.8.2586-2597.2002 }}
{{refend}}

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{{PDB Gallery |geneid = 91}}
{{TGF beta signaling}}
{{酶联受体}}

{{Portal bar|遗传学|分子与細胞生物学}}

[[Category:位於12號人類染色體的基因]]
[[Category:人类蛋白质]]
[[Category:受体]]
[[Category:EC 2.7.11]]

ACVR1B - 版本历史

imported>InternetArchiveBot：​Add 6 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot

imported>InternetArchiveBot：Add 6 books for verifiability (20251017sim)) #IABot (v2.0.9.5) (GreenC bot