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AC-42 - 版本历史
2026-07-18T01:33:44Z
在这个wiki上该页的修订历史
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imported>Htmlzycq：使用HotCat已移除Category:苯甲醛; 已添加Category:芳族酮
2025-06-03T00:39:05Z
<p>使用<a href="/index.php?title=WP:HOTCAT&action=edit&redlink=1" class="new" title="WP:HOTCAT（页面不存在）">HotCat</a>已移除<a href="/wiki/Category:%E8%8B%AF%E7%94%B2%E9%86%9B" title="Category:苯甲醛">Category:苯甲醛</a>; 已添加<a href="/wiki/Category:%E8%8A%B3%E6%97%8F%E9%85%AE" title="Category:芳族酮">Category:芳族酮</a></p>
<p><b>新页面</b></p><div>{{Chembox<br />
| ImageFile = AC-42 Structure.svg<br />
| ImageSize = 200px<br />
| PIN = 4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine<br />
| OtherNames =<br />
| Section1 = {{Chembox Identifiers<br />
| CASNo = 244291-63-2<br />
| CASNo_Ref = {{Cascite|correct|ChemSpider}}<br />
| ChEMBL = 1242950<br />
| IUPHAR_ligand = 289<br />
| PubChem = 9948320<br />
| ChemSpiderID = 8123931<br />
| SMILES = O=C(C=1C=CC=CC1C)CCCN2CCC(CC2)CCCC<br />
| StdInChI = 1S/C20H31NO/c1-3-4-9-18-12-15-21(16-13-18)14-7-11-20(22)19-10-6-5-8-17(19)2/h5-6,8,10,18H,3-4,7,9,11-16H2,1-2H3<br />
| StdInChIKey = ANTKBACNWQHQJE-UHFFFAOYSA-N<br />
}}<br />
| Section2 = {{Chembox Properties<br />
| C=20|H=31|N=1|O=1<br />
| Appearance = <br />
| Density = <br />
| MeltingPt = <br />
| BoilingPt = <br />
| Solubility = <br />
}}<br />
| Section3 = {{Chembox Hazards<br />
| MainHazards =<br />
| FlashPt =<br />
| AutoignitionPt =<br />
}}<br />
}}<br />
'''{{PAGENAME}}'''是一种[[氮化合物|含氮]][[有机化合物]]，分子式[[C20H31NO|{{chem2|C20H31NO}}]]，可作为[[蕈毒碱型乙酰胆碱受体M1]]的选择性别构[[激动剂]]<ref>{{cite journal |last1=Decker |first1=Michael |last2=Holzgrabe |first2=Ulrike |title=M1 muscarinic cetylcholine receptor allosteric modulators as potential therapeutic opportunities for treating Alzheimer's disease |journal=MedChemComm |date=2012 |volume=3 |issue=7 |pages=752 |doi=10.1039/c2md20025b}}</ref><ref>{{cite journal |last1=Sams |first1=Anette G. |last2=Hentzer |first2=Morten |last3=Mikkelsen |first3=Gitte K. |last4=Larsen |first4=Krestian |last5=Bundgaard |first5=Christoffer |last6=Plath |first6=Niels |last7=Christoffersen |first7=Claus T. |last8=Bang-Andersen |first8=Benny |title=Discovery of N -{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential |journal=Journal of Medicinal Chemistry |date=9 September 2010 |volume=53 |issue=17 |pages=6386–6397 |doi=10.1021/jm100697g|pmid=20684563 }}</ref><ref>{{cite journal |last1=Daval |first1=Sandrine B. |last2=Valant |first2=Céline |last3=Bonnet |first3=Dominique |last4=Kellenberger |first4=Esther |last5=Hibert |first5=Marcel |last6=Galzi |first6=Jean-Luc |last7=Ilien |first7=Brigitte |title=Fluorescent Derivatives of AC-42 To Probe Bitopic Orthosteric/Allosteric Binding Mechanisms on Muscarinic M1 Receptors |journal=Journal of Medicinal Chemistry |date=8 March 2012 |volume=55 |issue=5 |pages=2125–2143 |doi=10.1021/jm201348t|pmid=22329602 |url=https://hal.archives-ouvertes.fr/hal-02193850/file/2012%20Daval%20%20J%20med%20Chem%20%281%29.pdf }}</ref>。<br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:芳族酮]]<br />
[[Category:哌啶]]</div>
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