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ABT-724 - 版本历史
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2025-06-07T02:00:27Z
<p><span class="autocomment">参考文献</span></p>
<p><b>新页面</b></p><div>{{Drugbox<br />
| Verifiedfields = changed<br />
| verifiedrevid = 477235138<br />
| IUPAC_name = 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole<br />
| image = ABT-724 Structure.svg<br />
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<!--Clinical data--><br />
| tradename = <br />
| licence_EU = <br />
| pregnancy_category = <br />
| legal_UK = <br />
| routes_of_administration =<br />
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<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| metabolism = <br />
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<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|CAS}}<br />
| CAS_number = 70006-24-5<br />
| ATC_suffix = <br />
| UNII_Ref = {{fdacite|changed|FDA}}<br />
| UNII = 4WV2575JWT<br />
| PubChem = 5025739<br />
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}<br />
| ChemSpiderID = 4204515<br />
| ChEMBL_Ref = {{ebicite|correct|EBI}}<br />
| ChEMBL = 440687<br />
<br />
<!--Chemical data--><br />
| C=17 | H=19 | N=5 <br />
| smiles = n2c1ccccc1[nH]c2CN(CC4)CCN4c3ncccc3<br />
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}<br />
| StdInChI = 1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)<br />
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}<br />
| StdInChIKey = FRPJGTNLZNXQEX-UHFFFAOYSA-N<br />
}}<br />
'''{{PAGENAMEBASE}}'''是一种含氮[[有机化合物]]，分子式[[C17H19N5|C<sub>17</sub>H<sub>19</sub>N<sub>5</sub>]]，是一种[[多巴胺受体D4|多巴胺受体D<sub>4</sub>]]的选择性[[激动剂]]<ref name="pmid15087502">{{cite journal | vauthors = Brioni JD, Moreland RB, Cowart M, Hsieh GC, Stewart AO, Hedlund P, Donnelly-Roberts DL, Nakane M, Lynch JJ, Kolasa T, Polakowski JS, Osinski MA, Marsh K, Andersson KE, Sullivan JP | display-authors = 6 | title = Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 17 | pages = 6758–6763 | date = April 2004 | pmid = 15087502 | pmc = 404118 | doi = 10.1073/pnas.0308292101 | doi-access = free | bibcode = 2004PNAS..101.6758B }}</ref>，作为治疗[[勃起功能障碍]]的潜在药物而开发<ref name="pmid15239663">{{cite journal | vauthors = Cowart M, Latshaw SP, Bhatia P, Daanen JF, Rohde J, Nelson SL, Patel M, Kolasa T, Nakane M, Uchic ME, Miller LN, Terranova MA, Chang R, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Martino BR, Lynch JJ, Sullivan JP, Hsieh GC, Moreland RB, Brioni JD, Stewart AO | display-authors = 6 | title = Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction | journal = Journal of Medicinal Chemistry | volume = 47 | issue = 15 | pages = 3853–3864 | date = July 2004 | pmid = 15239663 | doi = 10.1021/jm030505a }}</ref>。<br />
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==另见==<br />
* [[ABT-670]]<br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
==外部链接==<br />
<br />
[[Category:多巴胺激动剂]]<br />
[[Category:哌啶]]<br />
[[Category:苯并咪唑]]<br />
[[Category:2-吡啶基化合物]]</div>
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