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ABT-670 - 版本历史
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<p><b>新页面</b></p><div>{{Drugbox<br />
| Verifiedfields = changed<br />
| verifiedrevid = 456505806<br />
| IUPAC_name = 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide<br />
| image = ABT-670 Structure.svg<br />
| width =<br />
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<!--Clinical data--><br />
| tradename = <br />
| licence_EU = <br />
| pregnancy_category = <br />
| legal_UK = <br />
| routes_of_administration = <br />
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<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
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<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|CAS}}<br />
| CAS_number = 630119-43-6<br />
| ATC_suffix = <br />
| UNII_Ref = {{fdacite|changed|FDA}}<br />
| UNII = 4L6071XH2J<br />
| ChEMBL_Ref = {{ebicite|correct|EBI}}<br />
| ChEMBL = 219182<br />
| PubChem = 16094676<br />
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}<br />
| ChemSpiderID = 17252978<br />
<br />
<!--Chemical data--><br />
| C=19 | H=23 | N=3 | O=2 <br />
| smiles = [O-][n+]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C<br />
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}<br />
| StdInChI = 1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23)<br />
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}<br />
| StdInChIKey = PUMMPCXNEPHBNN-UHFFFAOYSA-N<br />
}}<br />
'''{{PAGENAME}}'''是一种含氮[[有机化合物]]，化学式[[C19H23N3O2|C<sub>19</sub>H<sub>23</sub>N<sub>3</sub>O<sub>2</sub>]]，能作为[[多巴胺受体D4|多巴胺受体D<sub>4</sub>]]的[[激动剂]]，为治疗[[勃起功能障碍]]研发<ref name=Patel>{{cite journal | vauthors = Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, Nelson SL, Cowart MD, Nakane M, Miller LN, Uchic ME, Terranova MA, El-Kouhen OF, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Chang R, Martino BR, Wetter JM, Marsh KC, Martin R, Darbyshire JF, Gintant G, Hsieh GC, Moreland RB, Sullivan JP, Brioni JD, Stewart AO | display-authors = 6 | title = Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction | journal = Journal of Medicinal Chemistry | volume = 49 | issue = 25 | pages = 7450–65 | date = December 2006 | pmid = 17149874 | doi = 10.1021/jm060662k }}</ref>。<br />
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它可以2-(4-哌啶基)吡啶-''N''-氧化物盐酸盐、{{lwd|Q83085589}}和[[甲醛]]为原料合成得到<!-- 固体，熔点177-180 °C --><ref name=Patel /><ref>Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q. Preparation of piperazinyl, piperidinyl and related acetamides and benzamides as dopamine D4 receptor agonists useful in treating sexual dysfunction. 2003. US20030229094 A1.</ref>。<br />
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==另见==<br />
* [[ABT-724]]<br />
<br />
==参考文献==<br />
{{Reflist}}<br />
{{chem-stub}}<br />
<br />
[[Category:多巴胺激动剂]]<br />
[[Category:哌啶]]<br />
[[Category:N-氧化吡啶]]<br />
[[Category:2-吡啶基化合物]]<br />
[[Category:间甲苯基化合物]]</div>
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