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A-84543 - 版本历史
2026-07-20T00:48:55Z
本wiki上该页面的版本历史
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imported>Hamish：+
2024-10-19T15:21:14Z
<p>+</p>
<p><b>新页面</b></p><div>{{Drugbox<br />
| Verifiedfields = changed<br />
| Watchedfields = changed<br />
| verifiedrevid = 477346372<br />
| IUPAC_name = 3-{{!(}}[(2''S'')-1-Methyl-2-pyrrolidinyl]methoxy}pyridine<br />
| image = A-84,543.svg<br />
| width = 175<br />
<br />
<!--Clinical data--><br />
| tradename =<br />
| routes_of_administration =<br />
<br />
<!--Identifiers--><br />
| CAS_number_Ref = {{cascite|correct|NIH}}<br />
| CAS_number = 161416-43-9<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = WSK2XM6RPF<br />
| ATC_suffix = None<br />
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}<br />
| ChEMBL_Ref = {{ebicite|changed|EBI}}<br />
| ChEMBL = 84149<br />
| PubChem = 9794141<br />
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}<br />
| ChemSpiderID = 7969908<br />
| smiles = CN1CCC[C@H]1COc2cccnc2<br />
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChI=1S/C11H16N2O/c1-13-7-3-4-10(13)9-14-11-5-2-6-12-8-11/h2,5-6,8,10H,3-4,7,9H2,1H3/t10-/m0/s1<br />
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}<br />
| StdInChIKey = MVLJPWPLDPHKST-JTQLQIEISA-N<br />
<br />
<!--Chemical data--><br />
| C=11 | H=16 | N=2 | O=1 <br />
}}<br />
'''{{PAGENAME}}'''是一种含氮[[有机化合物]]，分子式[[C11H16N2O|C<sub>11</sub>H<sub>16</sub>N<sub>2</sub>O]]，是[[美國雅培]]公司研发的[[菸鹼型乙醯膽鹼受體]][[激动剂]]，能作为开发相关化合物的[[先导化合物]]。<ref>{{cite journal | vauthors = Abreo MA, Lin NH, Garvey DS, Gunn DE, Hettinger AM, Wasicak JT, Pavlik PA, Martin YC, Donnelly-roberts DL, Anderson DJ, Sullivan JP, Williams M, Arneric SP, Holladay MW | display-authors = 6 | title = Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors | journal = Journal of Medicinal Chemistry | volume = 39 | issue = 4 | pages = 817–25 | date = February 1996 | pmid = 8632405 | doi = 10.1021/jm9506884 }}</ref><ref name=autogenerated1>{{cite journal | vauthors = Lin NH, Gunn DE, Li Y, He Y, Bai H, Ryther KB, Kuntzweiler T, Donnelly-Roberts DL, Anderson DJ, Campbell JE, Sullivan JP, Arneric SP, Holladay MW | display-authors = 6 | title = Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist | journal = Bioorganic & Medicinal Chemistry Letters | volume = 8 | issue = 3 | pages = 249–54 | date = February 1998 | pmid = 9871663 | doi = 10.1016/S0960-894X(98)00019-5 }}</ref><ref>{{cite journal | vauthors = Wei ZL, Xiao Y, Yuan H, Baydyuk M, Petukhov PA, Musachio JL, Kellar KJ, Kozikowski AP | display-authors = 6 | title = Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits | journal = Journal of Medicinal Chemistry | volume = 48 | issue = 6 | pages = 1721–4 | date = March 2005 | pmid = 15771418 | doi = 10.1021/jm0492406 }}</ref><ref>{{cite journal | vauthors = Carreras J, Avenoza A, Busto JH, Peregrina JM | title = Synthesis of azabicyclo[2.2.n]alkane systems as analogues of 3-[1-methyl-2-(S)-pyrrolidinyl- methoxy]pyridine (A-84543) | journal = The Journal of Organic Chemistry | volume = 72 | issue = 8 | pages = 3112–5 | date = April 2007 | pmid = 17371077 | doi = 10.1021/jo0700732 }}</ref><br />
<br />
==参考文献==<br />
{{reflist}}<br />
<br />
[[Category:烟碱激动剂]]<br />
[[Category:芳香醚]]<br />
[[Category:3-吡啶基化合物]]<br />
[[Category:吡咯烷]]<br />
[[Category:兴奋剂]]</div>
imported>Hamish