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{{Infobox rfam
| Name = 5.8S rRNA
| image = RF00002.jpg
| width =
| caption = 5.8S rRNA的預測[[二級結構]]。圖中亦對[[保守序列|序列保守性]]進行了標示。
| Symbol = 5_8S_rRNA
| AltSymbols =
| Rfam = RF00002
| miRBase =
| miRBase_family =
| RNA_type = [[基因]]; [[rRNA]]
| Tax_domain = [[真核生物]]; [[古菌]]
| GO = {{GO|0003735}} {{GO|0005840}}
| SO = {{SO|0000375}}
| CAS_number =
| EntrezGene =
| HGNCid =
| OMIM =
| PDB =
| RefSeq =
| Chromosome =
| Arm =
| Band =
| LocusSupplementaryData =
}}
在分子生物學中，'''5.8S核糖體RNA'''（'''5.8S rRNA''')是指一類[[非編碼RNA]]。它是真核生物[[核糖體]]的大亞基的組成成分，在[[翻译_(遗传学)|蛋白質轉譯]]中起重要作用。{{link-en|RNA聚合酶I|RNA polymerase I}}先[[轉錄]]出[[沉降係數]]爲45S的前體。該前體同樣包含[[18S rRNA]]和[[28S rRNA]]。5.8S rRNA在核糖體轉運中起作用<ref name=Abou_1997>{{cite journal | last = Abou | first = Elela S |author2= Nazar RN | year = 1997 | title = Role of the 5.8S rRNA in ribosome translocation | journal = Nucleic Acids Res | volume = 25 | pages = 1788–1794 | pmid = 9108162 | doi = 10.1093/nar/25.9.1788 | issue = 9 | pmc = 146658}}</ref>。它能夠和[[p53]]腫瘤抑制蛋白形成[[共價]]連接<ref name=Fontoura_197>{{cite journal | last = Fontoura | first = BM |author2=Atienza CA|author3=Sorokina EA|author4=Morimoto T|author5= Carroll RB | year = 1997 | title = Cytoplasmic p53 polypeptide is associated with ribosomes | url = https://archive.org/details/sim_molecular-and-cellular-biology_1997-06_17_6/page/3146 | journal = Mol Cell Biol | volume = 17 | pages = 3146–3154 | pmid = 9154813 | issue = 6 | pmc = 232167}}</ref>。

5.8S rRNA可以作爲[[RT-PCR]]检测[[miRNA]]表达量的内参基因<ref name="s58_real">{{cite journal |author=Shi R, Chiang VL |title=Facile means for quantifying microRNA expression by real-time PCR |journal=BioTechniques |volume=39 |issue=4 |pages=519–25 |date=October 2005 |pmid=16235564 |doi=10.2144/000112010 |url=http://www.biotechniques.com/article/000112010 |accessdate=2010-09-15 |archive-date=2012-07-31 |archive-url=https://archive.today/20120731010516/http://www.biotechniques.com/article/000112010 |dead-url=yes }}</ref>。

==參考==
{{reflist|1}}

==外部連結==
* {{Rfam|id=RF00002|name=5.8S ribosomal RNA}}
* [http://www.ncbi.nlm.nih.gov/nuccore/186498419 Arabidopsis 5.8S rRNA sequence]{{Wayback|url=http://www.ncbi.nlm.nih.gov/nuccore/186498419 |date=20160305183557 }}
* [http://www.ncbi.nlm.nih.gov/nuccore/169814 Rice 5.8S rRNA sequence]{{Wayback|url=http://www.ncbi.nlm.nih.gov/nuccore/169814 |date=20160305175831 }}

{{Ribosome subunits}}

[[Category:核糖體RNA]]

{{molecular-cell-biology-stub}}

5.8S rRNA - 版本历史

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